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anti-CD2BP2 antibody :: Goat CD2BP2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420728
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD2BP2, Polyclonal Antibody

 Also Known As   

Goat anti-CD2BP2 (N Terminus) Antibody

 Product Synonym Names    CD2BP2; FWP010; LIN1; Snu40; CD2 antigen (cytoplasmic tail) binding protein 2; CD2 (cytoplasmic tail) binding protein 2; CD2 antigen (cytoplasmic tail)-binding protein 2; U5-52K; CD2 binding protein 2; CD2 cytoplasmic domain binding protein 2; U5 snRNP 52; CD2BP2 antibody; FWP010 antibody; LIN1 antibody; Snu40 antibody; CD2 antigen (cytoplasmic tail) binding protein 2 antibody; CD2 (cytoplasmic tail) binding protein 2 antibody; CD2 antigen (cytoplasmic tail)-binding protein 2 antibody; U5-52K antibody; CD2 binding protein 2 antibody; CD2 cytoplasmic domain binding protein 2 antibody; U5 snRNP 52K protein antibody; CD2BP2 (N Terminus)
 Product Gene Name   

anti-CD2BP2 antibody

[Similar Products]
 Antibody/Peptide Pairs    CD2BP2 peptide (MBS425252) is used for blocking the activity of CD2BP2 antibody (MBS420728)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    PKRKVTFQGV GDE
 OMIM    604470
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence PKRKVTFQGVGDE-C, from the N Terminus of the protein sequence according to NP_006101.1.
 Epitope    N Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CD2BP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD2BP2 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CD2BP2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Spleen shows nucleolar staining in select splenocytes. Recommended concentration, 5-10ug/ml.
Western Blot: Approx 50kDa band observed in Human Lymph Node, Thymus and Tonsil lysates (calculated MW of 37.6kDa according to NP_006101.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Nishizawa et al, Proc Natl Acad Sci U S A.1998 Dec 8;95(25): 14897-902). Recommended concentration: 0.3-1. 0ug/ml.
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 Western Blot (WB) of anti-CD2BP2 antibody    (0.3ug/ml) staining of Human Thymus lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-CD2BP2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CD2BP2 antibody    (5ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-CD2BP2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD2BP2. It may not necessarily be applicable to this product.
 NCBI GI #    5174409
 NCBI GeneID    10421
 NCBI Accession #    NP_006101.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006110.2 [Other Products]
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 UniProt Secondary Accession #    Q9ULP2; B2RDX2 [Other Products]
 UniProt Related Accession #    O95400 [Other Products]
 Molecular Weight    37,646 Da
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 NCBI Official Full Name    CD2 antigen cytoplasmic tail-binding protein 2
 NCBI Official Synonym Full Names    CD2 (cytoplasmic tail) binding protein 2
 NCBI Official Symbol    CD2BP2 [Similar Products]
 NCBI Official Synonym Symbols   
LIN1; Snu40; FWP010; U5-52K; PPP1R59
[Similar Products]
 NCBI Protein Information    CD2 antigen cytoplasmic tail-binding protein 2
 UniProt Protein Name    CD2 antigen cytoplasmic tail-binding protein 2
 UniProt Synonym Protein Names   
U5 snRNP 52K protein; U5-52K
 Protein Family    CD2 antigen cytoplasmic tail-binding protein
 UniProt Gene Name    CD2BP2 [Similar Products]
 UniProt Synonym Gene Names    KIAA1178; CD2 cytoplasmic domain-binding protein 2; CD2 tail-binding protein 2; U5-52K [Similar Products]
 UniProt Entry Name    CD2B2_HUMAN
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 NCBI Summary for CD2BP2    This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]
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 UniProt Comments for CD2BP2    CD2BP2: Binds the cytoplasmic domain of CD2 through the GYF domain.

Protein type: Adaptor/scaffold; Spliceosome; RNA processing

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoplasm; nuclear speck; nucleoplasm; nucleus; snRNP U5; U4/U6 x U5 tri-snRNP complex

Molecular Function: protein binding; ribonucleoprotein binding

Biological Process: assembly of spliceosomal tri-snRNP; nuclear mRNA splicing, via spliceosome
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 Research Articles on CD2BP2    1. findings indicate that CD2BP2 is not a constitutive binding partner or key regulator of CD2-mediated signaling events
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD2BP2 antibodyPathways associated with anti-CD2BP2 antibody
 Reference Product  PubMed Publications
 CD2 antibody  >14 publications with CD2BP2 and CD2
 SNRPF antibody  >3 publications with CD2BP2 and SNRPF
 SNRPB antibody  >1 publications with CD2BP2 and SNRPB
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 Spliceosome, U4/U6.U5 Tri-snRNP Pathway antibodies  Spliceosome, U4/U6.U5 Tri-snRNP Pathway Diagram
 Spliceosome, U4/U6.U5 Tri-snRNP Pathway antibodies  Spliceosome, U4/U6.U5 Tri-snRNP Pathway Diagram
 MRNA Splicing Pathway antibodies  MRNA Splicing Pathway Diagram
 MRNA Splicing - Major Pathway antibodies  MRNA Splicing - Major Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram
Diseases associated with anti-CD2BP2 antibodyOrgans/Tissues associated with anti-CD2BP2 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >2 publications with CD2BP2 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >1 publications with CD2BP2 and Cardiovascular Diseases
 Genital Diseases, Male Antibodies  >1 publications with CD2BP2 and Genital Diseases, Male
 Proteinuria Antibodies  >1 publications with CD2BP2 and Proteinuria
 Death Antibodies  >1 publications with CD2BP2 and Death
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with CD2BP2 and Blood
 Kidney Antibodies  >2 publications with CD2BP2 and Kidney
 Bone Marrow Antibodies  >1 publications with CD2BP2 and Bone Marrow
 Spleen Antibodies  >1 publications with CD2BP2 and Spleen
 Bone Antibodies  >1 publications with CD2BP2 and Bone
 Testis Antibodies  >1 publications with CD2BP2 and Testis
 Mammary Gland Antibodies  >1 publications with CD2BP2 and Mammary Gland
 Brain Antibodies  >1 publications with CD2BP2 and Brain
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