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anti-CD37 antibody :: Rabbit anti-Human CD37 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9205523
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD37, Polyclonal Antibody

 Also Known As   

CD37 Antibody (Center)

 Product Synonym Names    Leukocyte antigen CD37; Tetraspanin-26; Tspan-26; CD37; CD37; TSPAN26
 Product Gene Name   

anti-CD37 antibody

[Similar Products]
 Antibody/Peptide Pairs    CD37 peptide (MBS9217811) is used for blocking the activity of CD37 antibody (MBS9205523)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    101-130
 OMIM    151523
 3D Structure    ModBase 3D Structure for P11049
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This CD37 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-130 amino acids from the Central region of human CD37.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-CD37 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD37 antibody

   The protein encoded by this gene is a member of the
transmembrane 4 superfamily, also known as the tetraspanin family.
Most of these members are cell-surface proteins that are
characterized by the presence of four hydrophobic domains. The
proteins mediate signal transduction events that play a role in the
regulation of cell development, activation, growth and motility.
This encoded protein is a cell surface glycoprotein that is known
to complex with integrins and other transmembrane 4 superfamily
proteins. It may play a role in T-cell-B-cell interactions.
Alternate splicing results in multiple transcript variants encoding
different isoforms.
 Product Categories/Family for anti-CD37 antibody    Immunology
 Applications Tested/Suitable for anti-CD37 antibody   

Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB)

 Application Notes for anti-CD37 antibody    WB~~1:1000
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 Western Blot (WB) of anti-CD37 antibody    Western blot analysis of lysates from U-937, Daudi cell line (from left to right), using CD37 Antibody (Center). MBS9205523 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
anti-CD37 antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC/FACS) of anti-CD37 antibody    CD37 Antibody (Center) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-CD37 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for CD37. It may not necessarily be applicable to this product.
 NCBI GI #    91807110
 NCBI GeneID    951
 NCBI Accession #    NP_001035120.1 [Other Products]
 NCBI Related Accession #    NP_001765.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040031.1 [Other Products]
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 UniProt Primary Accession #    P11049 [Other Products]
 UniProt Secondary Accession #    Q3KPF9; B4DVC1 [Other Products]
 UniProt Related Accession #    P11049 [Other Products]
 Molecular Weight    31703
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 NCBI Official Full Name    leukocyte antigen CD37 isoform B
 NCBI Official Synonym Full Names    CD37 molecule
 NCBI Official Symbol    CD37 [Similar Products]
 NCBI Official Synonym Symbols   
GP52-40; TSPAN26
[Similar Products]
 NCBI Protein Information    leukocyte antigen CD37
 UniProt Protein Name    Leukocyte antigen CD37
 UniProt Synonym Protein Names   
Tetraspanin-26; Tspan-26; CD_antigen: CD37
 Protein Family    Leukocyte antigen
 UniProt Gene Name    CD37 [Similar Products]
 UniProt Synonym Gene Names    TSPAN26; Tspan-26 [Similar Products]
 UniProt Entry Name    CD37_HUMAN
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 NCBI Summary for CD37    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD37    CD37: is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: membrane; integral to membrane; immunological synapse

Molecular Function: protein binding

Biological Process: negative regulation of cell proliferation; positive regulation of immunoglobulin production; negative regulation of myeloid dendritic cell activation; regulation of humoral immune response; regulation of defense response to virus; defense response to protozoan
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Product References and Citations for anti-CD37 antibody

   Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gartlan, K.H., et al. J. Immunol. 185(6):3158-3166(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Zhao, X., et al. Blood 110(7):2569-2577(2007)
Meyer-Wentrup, F., et al. J. Immunol. 178(1):154-162(2007)
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 Research Articles on CD37    1. The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD37 antibodyPathways associated with anti-CD37 antibody
 Reference Product  PubMed Publications
 CD22 antibody  >41 publications with CD37 and CD22
 UPK1B antibody  >2 publications with CD37 and UPK1B
 SYK antibody  >2 publications with CD37 and SYK
 LYN antibody  >1 publications with CD37 and LYN
 Products by Pathway  Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
Diseases associated with anti-CD37 antibodyOrgans/Tissues associated with anti-CD37 antibody
 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >12 publications with CD37 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >8 publications with CD37 and Cardiovascular Diseases
 Skin Diseases Antibodies  >7 publications with CD37 and Skin Diseases
 Anemia Antibodies  >7 publications with CD37 and Anemia
 Inflammation Antibodies  >7 publications with CD37 and Inflammation
 Necrosis Antibodies  >6 publications with CD37 and Necrosis
 Disease Models, Animal Antibodies  >5 publications with CD37 and Disease Models, Animal
 Skin Neoplasms Antibodies  >4 publications with CD37 and Skin Neoplasms
 Breast Neoplasms Antibodies  >2 publications with CD37 and Breast Neoplasms
 Kidney Diseases Antibodies  >2 publications with CD37 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >125 publications with CD37 and Blood
 Bone Antibodies  >30 publications with CD37 and Bone
 Bone Marrow Antibodies  >28 publications with CD37 and Bone Marrow
 Lymph Node Antibodies  >19 publications with CD37 and Lymph Node
 Lymph Antibodies  >17 publications with CD37 and Lymph
 Spleen Antibodies  >11 publications with CD37 and Spleen
 Thymus Antibodies  >7 publications with CD37 and Thymus
 Lung Antibodies  >4 publications with CD37 and Lung
 Pharynx Antibodies  >4 publications with CD37 and Pharynx
 Vascular Antibodies  >4 publications with CD37 and Vascular
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