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anti-CD38 antibody :: Rabbit CD38 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS129421
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD38, Polyclonal Antibody

★Popular Item★
 Also Known As   

CD38 Polyclonal Antibody

 Product Synonym Names    ADPRC 1; ADPRC1
 Product Gene Name   

anti-CD38 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107270
 3D Structure    ModBase 3D Structure for P28907
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein of human CD38
 Calculated Molecular Weight    13kDa/34kDa
 Observd MW    45kDa
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 Other Notes    Small volumes of anti-CD38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD38 antibody

   The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants
 Product Categories/Family for anti-CD38 antibody    Polyclonal
 Applications Tested/Suitable for anti-CD38 antibody   

Western Blot (WB)

 Application Notes for anti-CD38 antibody    WB: 1:500 - 1:2000
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 Western Blot (WB) of anti-CD38 antibody    Western blot analysis of extracts of various cell lines, using CD38 Antibody at 1:500 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit
Exposure time: 90s
anti-CD38 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CD38. It may not necessarily be applicable to this product.
 NCBI GI #    55977782
 NCBI GeneID    952
 NCBI Accession #    P28907.2 [Other Products]
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 UniProt Primary Accession #    P28907 [Other Products]
 UniProt Secondary Accession #    O00121; O00122; Q96HY4 [Other Products]
 UniProt Related Accession #    P28907 [Other Products]
 Molecular Weight    300
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 NCBI Official Full Name    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
 NCBI Official Synonym Full Names    CD38 molecule
 NCBI Official Symbol    CD38 [Similar Products]
 NCBI Official Synonym Symbols   
T10; ADPRC 1
[Similar Products]
 NCBI Protein Information    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; CD38 antigen (p45); NAD(+) nucleosidase; ADP-ribosyl cyclase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
 UniProt Protein Name    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
 UniProt Synonym Protein Names   
2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20); 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD_antigen: CD38
 Protein Family    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
 UniProt Gene Name    CD38 [Similar Products]
 UniProt Synonym Gene Names    ADPRC 1; cADPr hydrolase 1 [Similar Products]
 UniProt Entry Name    CD38_HUMAN
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 NCBI Summary for CD38    CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD38    CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.2.2.6; EC 2.4.99.20; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Hydrolase; Cell surface; Apoptosis; Lyase; Membrane protein, integral; Cell cycle regulation

Chromosomal Location of Human Ortholog: 4p15

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; nucleus

Molecular Function: transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity

Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; response to hydroperoxide; positive regulation of B cell proliferation; positive regulation of vasoconstriction; response to hypoxia; response to progesterone stimulus; negative regulation of transcription, DNA-dependent; negative regulation of bone resorption; negative regulation of apoptosis
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 Research Articles on CD38    1. nominal associations were found between autism spectrum disorder scores and single-nucleotide polymorphisms in OXT, ARNT2 and CD38
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD38 antibodyPathways associated with anti-CD38 antibody
 Reference Product  PubMed Publications
 CD4 antibody  >1143 publications with CD38 and CD4
 CD27 antibody  >245 publications with CD38 and CD27
 IL6 antibody  >26 publications with CD38 and IL6
 LCK antibody  >8 publications with CD38 and LCK
 BST1 antibody  >3 publications with CD38 and BST1
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram
Diseases associated with anti-CD38 antibodyOrgans/Tissues associated with anti-CD38 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >430 publications with CD38 and Cardiovascular Diseases
 Inflammation Antibodies  >255 publications with CD38 and Inflammation
 Necrosis Antibodies  >199 publications with CD38 and Necrosis
 Liver Diseases Antibodies  >97 publications with CD38 and Liver Diseases
 Nervous System Diseases Antibodies  >94 publications with CD38 and Nervous System Diseases
 Anemia Antibodies  >91 publications with CD38 and Anemia
 Neoplasms, Experimental Antibodies  >77 publications with CD38 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >68 publications with CD38 and Disease Models, Animal
 Carcinoma Antibodies  >62 publications with CD38 and Carcinoma
 Breast Neoplasms Antibodies  >43 publications with CD38 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3688 publications with CD38 and Blood
 Bone Marrow Antibodies  >1354 publications with CD38 and Bone Marrow
 Lymph Node Antibodies  >278 publications with CD38 and Lymph Node
 Liver Antibodies  >215 publications with CD38 and Liver
 Lymph Antibodies  >206 publications with CD38 and Lymph
 Spleen Antibodies  >160 publications with CD38 and Spleen
 Muscle Antibodies  >131 publications with CD38 and Muscle
 Brain Antibodies  >117 publications with CD38 and Brain
 Tonsil Antibodies  >112 publications with CD38 and Tonsil
 Pharynx Antibodies  >106 publications with CD38 and Pharynx
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