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anti-CD3E antibody :: Rabbit anti-Human CD3E Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241109
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $605 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD3E, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human CD3E

 Product Synonym Names    Anti-CD3E Antibody (C-Terminus) IHC-plus; CD3E; CD3e antigen; CD3-epsilon; T-cell receptor epsilon chain; TCRE; T-cell receptors epsilon chain; T3E; CD3 Epsilon; Human CD3E
 Product Gene Name   

anti-CD3E antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 615615
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Peptide corresponding to the C-terminus of human CD3 epsilon subunit
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, pH 7.4, 0.05% sodium azide.
 Concentration    0.2 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human CD3E.
 Immunogen Type    Synthetic peptide
 Immunogen    CD3E antibody was raised against synthetic peptide from human CD3E.
 Antigen Modification    C-Terminus
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-CD3E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD3E antibody

   The CD3-Epsilon polypeptide (CD3E), which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. CD3plays an essential role in T-cell development.
 Applications Tested/Suitable for anti-CD3E antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-CD3E antibody    IHC-P (5 ug/ml), WB (0.5 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-CD3E antibody    Anti-CD3E antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-CD3E antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD3E. It may not necessarily be applicable to this product.
 NCBI GI #    4502671
 NCBI GeneID    916
 NCBI Accession #    NP_000724.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000733.3 [Other Products]
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 UniProt Secondary Accession #    A8K997 [Other Products]
 UniProt Related Accession #    P07766 [Other Products]
 Molecular Weight    23,147 Da
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 NCBI Official Full Name    T-cell surface glycoprotein CD3 epsilon chain
 NCBI Official Synonym Full Names    CD3e molecule, epsilon (CD3-TCR complex)
 NCBI Official Symbol    CD3E [Similar Products]
 NCBI Official Synonym Symbols   
T3E; TCRE; IMD18
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
 UniProt Protein Name    T-cell surface glycoprotein CD3 epsilon chain
 UniProt Synonym Protein Names   
T-cell surface antigen T3/Leu-4 epsilon chain; CD_antigen: CD3e
 Protein Family    T-cell surface glycoprotein
 UniProt Gene Name    CD3E [Similar Products]
 UniProt Synonym Gene Names    T3E [Similar Products]
 UniProt Entry Name    CD3E_HUMAN
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 NCBI Summary for CD3E    The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD3E    CD3E: a T cell surface glycoprotein that is a component of the T cell antigen receptor. The recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Contains 1 immunoglobulin-like domain and 1 ITAM domain.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane; immunological synapse; alpha-beta T cell receptor complex; intercellular junction; external side of plasma membrane

Molecular Function: protein binding; receptor signaling complex scaffold activity; transmembrane receptor activity; protein heterodimerization activity; receptor signaling protein activity; T cell receptor binding; SH3 domain binding; protein kinase binding

Biological Process: regulation of immune response; T cell activation; positive regulation of interleukin-2 biosynthetic process; signal complex assembly; positive regulation of calcium-mediated signaling; T cell receptor signaling pathway; negative thymic T cell selection; positive regulation of interleukin-4 production; regulation of apoptosis; G-protein coupled receptor protein signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; negative regulation of smoothened signaling pathway; T cell costimulation; protein complex assembly; positive regulation of alpha-beta T cell proliferation; positive regulation of T cell proliferation; positive regulation of T cell anergy; transmembrane receptor protein tyrosine kinase signaling pathway; response to nutrient

Disease: Immunodeficiency 18
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 Research Articles on CD3E    1. that Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck-CD3epsilon interaction may represent a target for pharmacological modulation of the immune response.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD3E antibodyPathways associated with anti-CD3E antibody
 Reference Product  PubMed Publications
 CD4 antibody  >67 publications with CD3E and CD4
 LCK antibody  >16 publications with CD3E and LCK
 ZAP70 antibody  >16 publications with CD3E and ZAP70
 CD3D antibody  >13 publications with CD3E and CD3D
 CD3G antibody  >8 publications with CD3E and CD3G
 CD8A antibody  >7 publications with CD3E and CD8A
 SYK antibody  >4 publications with CD3E and SYK
 CD247 antibody  >2 publications with CD3E and CD247
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Generation Of Second Messenger Molecules Pathway antibodies  Generation Of Second Messenger Molecules Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
Diseases associated with anti-CD3E antibodyOrgans/Tissues associated with anti-CD3E antibody
 Disease Name  Pubmed Publications
 Lymphoma Antibodies  >26 publications with CD3E and Lymphoma
 Inflammation Antibodies  >19 publications with CD3E and Inflammation
 Necrosis Antibodies  >13 publications with CD3E and Necrosis
 Immunologic Deficiency Syndromes Antibodies  >13 publications with CD3E and Immunologic Deficiency Syndromes
 Neoplasms, Experimental Antibodies  >7 publications with CD3E and Neoplasms, Experimental
 Lung Diseases Antibodies  >5 publications with CD3E and Lung Diseases
 Carcinoma Antibodies  >5 publications with CD3E and Carcinoma
 Arthritis, Rheumatoid Antibodies  >5 publications with CD3E and Arthritis, Rheumatoid
 Severe Combined Immunodeficiency Antibodies  >4 publications with CD3E and Severe Combined Immunodeficiency
 Liver Diseases Antibodies  >4 publications with CD3E and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >189 publications with CD3E and Blood
 Thymus Antibodies  >46 publications with CD3E and Thymus
 Spleen Antibodies  >34 publications with CD3E and Spleen
 Lymph Node Antibodies  >16 publications with CD3E and Lymph Node
 Liver Antibodies  >12 publications with CD3E and Liver
 Intestine Antibodies  >10 publications with CD3E and Intestine
 Brain Antibodies  >6 publications with CD3E and Brain
 Lung Antibodies  >6 publications with CD3E and Lung
 Kidney Antibodies  >6 publications with CD3E and Kidney
 Heart Antibodies  >4 publications with CD3E and Heart
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