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anti-CD4 antibody :: Rabbit CD4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS551067
Immunohistochemistry
Unit / Price
0.1 mg  /  $280 +1 FREE 8GB USB
0.2 mg  /  $385 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD4, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti CD4 Polyclonal

 Product Synonym Names    Rabbit anti CD4 Polyclonal purified; cd4; cd-4; polyclonal; PAb
 Product Gene Name   

anti-CD4 antibody

[Similar Products]
 Product Synonym Gene Name    CD4 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    186830
 3D Structure    ModBase 3D Structure for P07766
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Serum IgG fraction was purified by Protein G affinity chromatography.
 Form/Format    Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
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 Source Note    Polyclonal CD4 antibody was produced from sera of rabbits immunized with synthetic protein containing CD4 antigenic determinants.
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
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 Preparation and Storage    The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C.
Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Shelf Life: >12 months
 Other Notes    Small volumes of anti-CD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD4 antibody

   CD4 is a 55 kDa transmembrane glycoprotein belonging to the immunoglobulin superfamily. In humans CD4 is expressed of peripheral T-cells, thymocytes, on macrophages and granulocytes. CD4 acts as a cellular adhesion molecule binding MHC class 2 molecules. It stabilizes the interaction of MHC class 2 restricted T- cells and antigen-presenting cells expressing an antigen in combination with a MHC class 2 molecule. Interactions of CD4 with MHC class 2 molecules are crucial during thymic development and subsequently for the function of single- positive CD4 (+), CD8 (-) T- lymphocytes. CD4 functions as an effector molecule for intracellular signal transduction. In T- lymphocytes CD4 has been found to be associated with tyrosine kinase lck which phosphorylates a number of other cell surface proteins and is involved probably in transducing the intracellular signal when these proteins are bound to their receptors.
 Product Categories/Family for anti-CD4 antibody    Polyclonal
 Applications Tested/Suitable for anti-CD4 antibody   

Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA)

 Application Notes for anti-CD4 antibody    ELISA: Use at a concentration range of 1-2ug/ml.
WB: A suitable range of concentrations of this antibody for WB is 2-10 ug/ml.
IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.
Immunohistochemical analysis of FFPE human colorectal cancer sections showing lymphocyte expression of CD4.
It was used as primary antibody, dilution 1:400, DAB chromogenic staining.

Immunohistochemical analysis of FFPE mouse kidney sections showing lymphocyte expression of CD4.
It was used as primary antibody, dilution 1:200, DAB chromogenic staining.
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 Immunohistochemistry of anti-CD4 antibody    anti-CD4 antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for CD4. It may not necessarily be applicable to this product.
 NCBI GI #    4502671
 NCBI GeneID    916
 NCBI Accession #    NP_000724.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000733.3 [Other Products]
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 UniProt Primary Accession #    P07766 [Other Products]
 UniProt Secondary Accession #    A8K997 [Other Products]
 UniProt Related Accession #    P07766 [Other Products]
 Molecular Weight    23,147 Da
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 NCBI Official Full Name    T-cell surface glycoprotein CD3 epsilon chain
 UniProt Protein Name    T-cell surface glycoprotein CD3 epsilon chain
 UniProt Synonym Protein Names   
T-cell surface antigen T3/Leu-4 epsilon chain
 Protein Family    CD40 ligand
 UniProt Gene Name    CD3E [Similar Products]
 UniProt Synonym Gene Names    T3E [Similar Products]
 UniProt Entry Name    CD3E_HUMAN
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 NCBI Summary for CD4    The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD4    CD3E: a T cell surface glycoprotein that is a component of the T cell antigen receptor. The recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Contains 1 immunoglobulin-like domain and 1 ITAM domain.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane; immunological synapse; alpha-beta T cell receptor complex; intercellular junction; external side of plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; receptor signaling complex scaffold activity; protein heterodimerization activity; receptor signaling protein activity; T cell receptor binding; protein kinase binding; SH3 domain binding

Biological Process: regulation of immune response; T cell activation; positive regulation of interleukin-2 biosynthetic process; signal complex assembly; positive regulation of calcium-mediated signaling; T cell receptor signaling pathway; negative thymic T cell selection; positive regulation of interleukin-4 production; regulation of apoptosis; G-protein coupled receptor protein signaling pathway; positive regulation of interferon-gamma production; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; negative regulation of smoothened signaling pathway; T cell costimulation; positive regulation of alpha-beta T cell proliferation; positive regulation of T cell proliferation; protein complex assembly; positive regulation of T cell anergy; transmembrane receptor protein tyrosine kinase signaling pathway; response to nutrient

Disease: Immunodeficiency 18
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Product References and Citations for anti-CD4 antibody

   hiv-infected ugandan adults taking antiretroviral therapy with CD4 counts >200 cells/μl who discontinue cotrimoxazole prophylaxis have increased risk of malaria and diarrhea .Clinical Infectious Diseases, Apr 2012; 54: 1204 - 1211.
CD4+ type ii nkt cells mediate icos and programmed death-1–dependent regulation of type 1 diabetes .J. Immunol., Apr 2012; 188: 3138 - 3149.
spatial alterations between CD4+ t follicular helper, b, and cd8+ t cells during simian immunodeficiency virus infection: t/b cell homeostasis, activation, and potential mechanism for viral escape .J. Immunol., Apr 2012; 188: 3247 - 3256.
dissection of a circulating and intrahepatic CD4+foxp3+ t-cell subpopulation in chronic hepatitis b virus (hbv) infection: a highly informative strategy for distinguishing chronic hbv infection states .The Journal of Infectious Disease, Apr 2012; 205: 1111 - 1120.
mhc class ib-restricted cd8 t cells differ in dependence on CD4 t cell help and cd28 costimulation over the course of mouse polyomavirus infection .J. Immunol., Apr 2012; 188: 3071 - 3079.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD4 antibodyPathways associated with anti-CD4 antibody
 Reference Product  PubMed Publications
 ZAP70 antibody  >13 publications with CD4 and ZAP70
 LCK antibody  >13 publications with CD4 and LCK
 CD3D antibody  >9 publications with CD4 and CD3D
 CD3G antibody  >6 publications with CD4 and CD3G
 SYK antibody  >3 publications with CD4 and SYK
 CD79B antibody  >3 publications with CD4 and CD79B
 NCK2 antibody  >1 publications with CD4 and NCK2
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Generation Of Second Messenger Molecules Pathway antibodies  Generation Of Second Messenger Molecules Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
Diseases associated with anti-CD4 antibodyOrgans/Tissues associated with anti-CD4 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >14 publications with CD4 and Inflammation
 Immunologic Deficiency Syndromes Antibodies  >10 publications with CD4 and Immunologic Deficiency Syndromes
 Carcinoma Antibodies  >5 publications with CD4 and Carcinoma
 Liver Diseases Antibodies  >4 publications with CD4 and Liver Diseases
 Skin Neoplasms Antibodies  >4 publications with CD4 and Skin Neoplasms
 Drug Toxicity Antibodies  >3 publications with CD4 and Drug Toxicity
 Fibrosis Antibodies  >2 publications with CD4 and Fibrosis
 Gastritis Antibodies  >2 publications with CD4 and Gastritis
 Lung Neoplasms Antibodies  >2 publications with CD4 and Lung Neoplasms
 Kidney Diseases Antibodies  >2 publications with CD4 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >155 publications with CD4 and Blood
 Thymus Antibodies  >40 publications with CD4 and Thymus
 Spleen Antibodies  >28 publications with CD4 and Spleen
 Lymph Node Antibodies  >12 publications with CD4 and Lymph Node
 Liver Antibodies  >10 publications with CD4 and Liver
 Intestine Antibodies  >8 publications with CD4 and Intestine
 Lung Antibodies  >7 publications with CD4 and Lung
 Brain Antibodies  >4 publications with CD4 and Brain
 Heart Antibodies  >3 publications with CD4 and Heart
 Eye Antibodies  >3 publications with CD4 and Eye
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