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anti-CD40 antibody :: Rabbit CD40 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS244648
Immunohistochemistry (IHC)
Unit / Price
0.25 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD40, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal (IgG) to Human CD40

 Product Synonym Names    Anti-CD40 Antibody (C-Terminus) IHC-plus; CD40; B-cell surface antigen CD40; B cell-associated molecule; B cell surface antigen CD40; CD40 antigen; CD40 type II isoform; p50; Bp50; CD40L receptor; CDW40; TNFRSF5; Human CD40
 Product Gene Name   

anti-CD40 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 606843
 3D Structure    ModBase 3D Structure for P25942
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunoaffinity Purified
 Form/Format    10 mM PBS, pH 7.4, BSA, sodium azide.
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 Target Species    Human
 Immunogen Description    A synthetic peptide derived from C-terminal of human CD40.
 Immunogen Type    Synthetic peptide
 Immunogen    CD40 antibody was raised against a synthetic peptide derived from C-terminal of human CD40.
 Antigen Modification    C-Terminus
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 Preparation and Storage    Store at 2 degree C to 8 degree C degrees. Do not freeze.
 Other Notes    Small volumes of anti-CD40 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD40 antibody

   CD40 is a member of the TNF-receptor superfamily. It has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions.
 Product Categories/Family for anti-CD40 antibody    Family: TNF Receptor
 Applications Tested/Suitable for anti-CD40 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-CD40 antibody    IHC-P (1:100), IP, WB
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 Immunohistochemistry (IHC) of anti-CD40 antibody    Anti-CD40 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
anti-CD40 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD40. It may not necessarily be applicable to this product.
 NCBI GI #    4507581
 NCBI GeneID    958
 NCBI Accession #    NP_001241.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001250.5 [Other Products]
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 UniProt Primary Accession #    P25942 [Other Products]
 UniProt Secondary Accession #    Q53GN5; Q5JY15; Q5U007; Q7M4Q8; Q86YK5; Q9BYU0; E1P5S9 [Other Products]
 UniProt Related Accession #    P25942 [Other Products]
 Molecular Weight    22,259 Da
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 5 isoform 1
 NCBI Official Synonym Full Names    CD40 molecule, TNF receptor superfamily member 5
 NCBI Official Symbol    CD40 [Similar Products]
 NCBI Official Synonym Symbols   
p50; Bp50; CDW40; TNFRSF5
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 5; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); nerve growth factor receptor-related B-lymphocyte activation molecule
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 5
 UniProt Synonym Protein Names   
B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD_antigen: CD40
 Protein Family    CD40 ligand
 UniProt Gene Name    CD40 [Similar Products]
 UniProt Synonym Gene Names    TNFRSF5 [Similar Products]
 UniProt Entry Name    TNR5_HUMAN
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 NCBI Summary for CD40    This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
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 UniProt Comments for CD40    CD40: a member of the TNF-receptor superfamily. This receptor for CD40L mediates a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3). HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation. Two alternatively spliced isoforms have been reported. Isoform I is a type I membrane protein; isoform II is secreted.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20q12-q13.2

Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; signal transducer activity; enzyme binding; ubiquitin protein ligase binding; receptor activity; antigen binding

Biological Process: B cell proliferation; platelet activation; positive regulation of isotype switching to IgG isotypes; regulation of immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 production; immune response-regulating cell surface receptor signaling pathway; activation of NF-kappaB transcription factor; cellular calcium ion homeostasis; positive regulation of MAP kinase activity; positive regulation of tyrosine phosphorylation of Stat1 protein; protein kinase B signaling cascade; positive regulation of B cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein complex assembly; positive regulation of protein amino acid phosphorylation; inflammatory response; defense response to virus; regulation of immunoglobulin secretion

Disease: Immunodeficiency With Hyper-igm, Type 3
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 Research Articles on CD40    1. Plasma lipids, atherogenic risk factors and leukocyte functionality are important for the atherogenic process.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD40 antibodyPathways associated with anti-CD40 antibody
 Reference Product  PubMed Publications
 CD86 antibody  >2316 publications with CD40 and CD86
 TRAF2 antibody  >175 publications with CD40 and TRAF2
 TRAF3 antibody  >134 publications with CD40 and TRAF3
 TRAF6 antibody  >112 publications with CD40 and TRAF6
 TRAF1 antibody  >81 publications with CD40 and TRAF1
 CD40LG antibody  >29 publications with CD40 and CD40LG
 JAK3 antibody  >27 publications with CD40 and JAK3
 BIRC3 antibody  >10 publications with CD40 and BIRC3
 BIRC2 antibody  >7 publications with CD40 and BIRC2
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Diseases associated with anti-CD40 antibodyOrgans/Tissues associated with anti-CD40 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2256 publications with CD40 and Necrosis
 Inflammation Antibodies  >1599 publications with CD40 and Inflammation
 Cardiovascular Diseases Antibodies  >1083 publications with CD40 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >729 publications with CD40 and Disease Models, Animal
 Atherosclerosis Antibodies  >481 publications with CD40 and Atherosclerosis
 Heart Diseases Antibodies  >453 publications with CD40 and Heart Diseases
 Neoplasms, Experimental Antibodies  >428 publications with CD40 and Neoplasms, Experimental
 Arthritis, Rheumatoid Antibodies  >258 publications with CD40 and Arthritis, Rheumatoid
 Liver Diseases Antibodies  >200 publications with CD40 and Liver Diseases
 Kidney Diseases Antibodies  >195 publications with CD40 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8809 publications with CD40 and Blood
 Bone Antibodies  >1285 publications with CD40 and Bone
 Lymph Node Antibodies  >894 publications with CD40 and Lymph Node
 Lymph Antibodies  >706 publications with CD40 and Lymph
 Skin Antibodies  >604 publications with CD40 and Skin
 Lung Antibodies  >431 publications with CD40 and Lung
 Liver Antibodies  >394 publications with CD40 and Liver
 Kidney Antibodies  >369 publications with CD40 and Kidney
 Brain Antibodies  >313 publications with CD40 and Brain
 Tonsil Antibodies  >221 publications with CD40 and Tonsil
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