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anti-PTPRC antibody :: Rabbit anti-Human CD45 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175628
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD45 (PTPRC), Polyclonal Antibody

 Also Known As   

Anti-CD45 antibody

 Product Synonym Names    Receptor-type tyrosine-protein phosphatase C; protein tyrosine phosphatase, receptor type, C; B220 antibody; CD 45 antibody; CD45 antibody; CD45 antigen antibody; CD45R antibody; GP180 antibody; L CA antibody; L-CA antibody; LCA antibody; Leukocyte common antigen antibody; loc antibody; Ly-5 antibody; LY5 antibody; Lyt-4 antibody; OTTHUMP00000033813 antibody; OTTHUMP00000033816 antibody; OTTHUMP00000033817 antibody; OTTHUMP00000038574 antibody; Protein tyrosine phosphatase receptor type C antibody; Protein tyrosine phosphatase receptor type c polypeptide antibody; protein tyrosine phosphatase, receptor type, C antibody; PTPRC antibody; PTPRC_HUMAN antibody; Receptor-type tyrosine-protein phosphatase C antibody; SCID due to PTPRC deficiency antibody; T200 antibody; T200 glycoprotein antibody; T200 leukocyte common antigen antibody
 Product Gene Name   

anti-PTPRC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 608971
 3D Structure    ModBase 3D Structure for P08575
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human CD45 (1209-1227aa MVSTFEQYQFLYDVIASTY).
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PTPRC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PTPRC antibody

   Description: Rabbit IgG polyclonal antibody for Receptor-type tyrosine-protein phosphatase C(PTPRC) detection. Tested with WB, IHC-P, ICC in Human.
Background: CD45(Cluster of Differentiation 45), also known as PTPRC, LCA or CD45R, is an enzyme that, in humans, is encoded by the PTPRC gene.CD45 is a member of the protein tyrosine phosphatase(PTP) family. CD45 is a major high molecular mass leukocyte cell surface molecule which is also an integral membrane protein tyrosine phosphatase.The cytogenetic location of CD45 is 1q31.3-q32.1. CD45 is especially a prototype for transmembrane protein-tyrosine phosphatase(PTP). Targeted disruption of the CD45 gene leads to enhanced cytokine and interferon receptor-mediated activation of JAKs and STAT proteins. In vitro, CD45 directly dephosphorylates and binds to JAKs. Functionally, CD45 negatively regulates interleukin-3-mediated cellular proliferation, erythropoietin-dependent hematopoiesis, and antiviral responses in vitro and in vivo. CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds. CD45 is moved into or out of the immunological synapse(IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton. Galectin interaction can be finetuned by varying usage of the heavily Oglycosylated spliced regions and sialylation of Nlinked carbohydrates.
 Applications Tested/Suitable for anti-PTPRC antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

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 Western Blot (WB) of anti-PTPRC antibody    Anti-CD45 antibody, MBS175628, Western blotting
All lanes: Anti CD45 (MBS175628) at 0.5ug/ml
Lane 1: JURKAT Whole Cell Lysate at 40ug
Lane 2: CEM Whole Cell Lysate at 40ug
Predicted bind size: 147KD
Observed bind size: 147KD
anti-PTPRC antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PTPRC antibody    Anti-CD45 antibody, MBS175628, IHC(P)
IHC(P): Human Tonsil Tissue
anti-PTPRC antibody Immunohistochemistry (IHC) (IHC) image
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 Immunocytochemistry (ICC) of anti-PTPRC antibody    Anti-CD45 antibody, MBS175628, ICC
ICC: JURKAT Cell
anti-PTPRC antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for PTPRC. It may not necessarily be applicable to this product.
 NCBI GI #    33112650
 NCBI GeneID    5788
 NCBI Accession #    P08575.2 [Other Products]
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 UniProt Primary Accession #    P08575 [Other Products]
 UniProt Secondary Accession #    Q16614; Q9H0Y6; A8K7W6 [Other Products]
 UniProt Related Accession #    P08575 [Other Products]
 Molecular Weight    130,898 Da
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 NCBI Official Full Name    Receptor-type tyrosine-protein phosphatase C
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, receptor type, C
 NCBI Official Symbol    PTPRC [Similar Products]
 NCBI Official Synonym Symbols   
LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180
[Similar Products]
 NCBI Protein Information    receptor-type tyrosine-protein phosphatase C; CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase, receptor type, c polypeptide
 UniProt Protein Name    Receptor-type tyrosine-protein phosphatase C
 UniProt Synonym Protein Names   
Leukocyte common antigen; L-CA; T200; CD_antigen: CD45
 Protein Family    Receptor-type tyrosine-protein phosphatase
 UniProt Gene Name    PTPRC [Similar Products]
 UniProt Synonym Gene Names    CD45; L-CA [Similar Products]
 UniProt Entry Name    PTPRC_HUMAN
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 NCBI Summary for PTPRC    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
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 UniProt Comments for PTPRC    CD45: a receptor type protein tyrosine phosphatase protein. Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The first PTPAse domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Specifically expressed in hematopoietic cells. An essential regulator of T- and B-cell antigen receptor signaling. Functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. Suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.3.48; Receptor protein phosphatase, tyrosine

Chromosomal Location of Human Ortholog: 1q31-q32

Cellular Component: focal adhesion; membrane; integral to plasma membrane; plasma membrane; external side of plasma membrane; lipid raft

Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; protein kinase binding

Biological Process: B cell proliferation; axon guidance; substrate-bound cell migration, cell release from substrate; regulation of cell cycle; protein amino acid dephosphorylation; T cell receptor signaling pathway; positive regulation of antigen receptor-mediated signaling pathway; bone marrow development; stem cell development; B cell receptor signaling pathway; cell surface receptor linked signal transduction; dephosphorylation; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; negative regulation of T cell mediated cytotoxicity; positive regulation of B cell proliferation; negative regulation of protein kinase activity; hemopoietic progenitor cell differentiation; negative regulation of cytokine and chemokine mediated signaling pathway; positive regulation of T cell proliferation; immunoglobulin biosynthetic process; defense response to virus; T cell differentiation

Disease: Hepatitis C Virus, Susceptibility To; Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-positive, Nk Cell-positive
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 Research Articles on PTPRC    1. Hematopoietic cell marker CD45 is expressed in hepatic progenitor cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PTPRC antibodyPathways associated with anti-PTPRC antibody
 Reference Product  PubMed Publications
 CD4 antibody  >2872 publications with PTPRC and CD4
 LCK antibody  >211 publications with PTPRC and LCK
 CXCR4 antibody  >122 publications with PTPRC and CXCR4
 CD22 antibody  >120 publications with PTPRC and CD22
 CD79A antibody  >85 publications with PTPRC and CD79A
 FYN antibody  >76 publications with PTPRC and FYN
 CD79B antibody  >49 publications with PTPRC and CD79B
 LYN antibody  >44 publications with PTPRC and LYN
 CSK antibody  >27 publications with PTPRC and CSK
 SEMA4D antibody  >5 publications with PTPRC and SEMA4D
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
Diseases associated with anti-PTPRC antibodyOrgans/Tissues associated with anti-PTPRC antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >645 publications with PTPRC and Inflammation
 Necrosis Antibodies  >465 publications with PTPRC and Necrosis
 Lung Diseases Antibodies  >257 publications with PTPRC and Lung Diseases
 Multiple Myeloma Antibodies  >186 publications with PTPRC and Multiple Myeloma
 Neoplasms, Experimental Antibodies  >160 publications with PTPRC and Neoplasms, Experimental
 Arthritis, Rheumatoid Antibodies  >144 publications with PTPRC and Arthritis, Rheumatoid
 Kidney Diseases Antibodies  >136 publications with PTPRC and Kidney Diseases
 Breast Neoplasms Antibodies  >106 publications with PTPRC and Breast Neoplasms
 Hyperplasia Antibodies  >94 publications with PTPRC and Hyperplasia
 Asthma Antibodies  >90 publications with PTPRC and Asthma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6737 publications with PTPRC and Blood
 Bone Antibodies  >1826 publications with PTPRC and Bone
 Bone Marrow Antibodies  >1710 publications with PTPRC and Bone Marrow
 Vascular Antibodies  >744 publications with PTPRC and Vascular
 Lymph Node Antibodies  >620 publications with PTPRC and Lymph Node
 Lymph Antibodies  >617 publications with PTPRC and Lymph
 Spleen Antibodies  >615 publications with PTPRC and Spleen
 Liver Antibodies  >503 publications with PTPRC and Liver
 Thymus Antibodies  >482 publications with PTPRC and Thymus
 Skin Antibodies  >459 publications with PTPRC and Skin
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