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anti-CD47 antibody :: Rabbit anti-Human, Rat CD47 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS177091
Testing Data
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD47, Polyclonal Antibody

 Also Known As   

Anti-CD47 antibody

 Product Synonym Names    Leukocyte surface antigen CD47; CD47 molecule; Antigenic surface determinant protein OA3 antibody; CD 47 antibody; CD47 antibody; Cd47 antibody; CD47 antigen(Rh-related antigen, integrin-associated signal transducer) antibody; CD47 antigen antibody; CD47 glycoprotein antibody; CD47 molecule antibody; CD47_HUMAN antibody; IAP antibody; Integrin Associated Protein antibody; Integrin associated signal transducer antibody; Integrin-associated protein antibody; Leukocyte surface antigen CD47 antibody; MER 6 antibody; MER6 antibody; OA 3 antibody; OA3 antibody; OTTHUMP00000041152 antibody; OTTHUMP00000041153 antibody; Protein MER6 antibody; Rh related antigen antibody
 Product Gene Name   

anti-CD47 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601028
 3D Structure    ModBase 3D Structure for Q08722
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human CD47 (308-323aa EPLNAFKESKGMMNDE), identical to the related rat sequence.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CD47 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD47 antibody

   Description: Rabbit IgG polyclonal antibody for Leukocyte surface antigen CD47(CD47) detection. Tested with WB, IHC-P in Human, Rat.
Background: CD47, also known as IAP or MER6, is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 gene belongs to the immunoglobulin superfamily. This gene is mapped to 3q13.12. CD47 gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes.
 Applications Tested/Suitable for anti-CD47 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

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 Testing Data of anti-CD47 antibody    anti-CD47 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD47. It may not necessarily be applicable to this product.
 NCBI GI #    1171879
 NCBI GeneID    961
 NCBI Accession #    Q08722.1 [Other Products]
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 UniProt Primary Accession #    Q08722 [Other Products]
 UniProt Secondary Accession #    Q53Y71; Q96A60; A8K198; D3DN59 [Other Products]
 UniProt Related Accession #    Q08722 [Other Products]
 Molecular Weight    33,845 Da
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 NCBI Official Full Name    Leukocyte surface antigen CD47
 NCBI Official Synonym Full Names    CD47 molecule
 NCBI Official Symbol    CD47 [Similar Products]
 NCBI Official Synonym Symbols   
IAP; OA3; MER6
[Similar Products]
 NCBI Protein Information    leukocyte surface antigen CD47; CD47 glycoprotein; Rh-related antigen; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; antigenic surface determinant protein OA3; antigen identified by monoclonal antibody 1D8; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
 UniProt Protein Name    Leukocyte surface antigen CD47
 UniProt Synonym Protein Names   
Antigenic surface determinant protein OA3; Integrin-associated protein; IAP; Protein MER6; CD_antigen: CD47
 Protein Family    Leukocyte surface antigen
 UniProt Gene Name    CD47 [Similar Products]
 UniProt Synonym Gene Names    MER6; IAP [Similar Products]
 UniProt Entry Name    CD47_HUMAN
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 NCBI Summary for CD47    This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
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 UniProt Comments for CD47    CD47: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q13.1-q13.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding

Biological Process: integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; response to bacterium; positive regulation of phagocytosis; positive regulation of cell proliferation; positive regulation of cell-cell adhesion; positive regulation of T cell activation; opsonization; cell adhesion; blood coagulation; leukocyte migration; positive regulation of inflammatory response
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 Research Articles on CD47    1. Suppression of CD47 by morpholino approach suppressed growth of hepatocellular carcinoma in vivo and exerted a chemosensitization effect through blockade of CTSS/PAR2 signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD47 antibodyPathways associated with anti-CD47 antibody
 Reference Product  PubMed Publications
 THBS1 antibody  >140 publications with CD47 and THBS1
 SIRPA antibody  >70 publications with CD47 and SIRPA
 RHAG antibody  >22 publications with CD47 and RHAG
 PTPN11 antibody  >7 publications with CD47 and PTPN11
 SIRPB1 antibody  >5 publications with CD47 and SIRPB1
 SIRPG antibody  >3 publications with CD47 and SIRPG
 THBS2 antibody  >1 publications with CD47 and THBS2
 ITGB3 antibody  >1 publications with CD47 and ITGB3
 ITGAV antibody  >1 publications with CD47 and ITGAV
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Integrins In Angiogenesis Pathway antibodies  Integrins In Angiogenesis Pathway Diagram
 Signal Regulatory Protein (SIRP) Family Interactions Pathway antibodies  Signal Regulatory Protein (SIRP) Family Interactions Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
Diseases associated with anti-CD47 antibodyOrgans/Tissues associated with anti-CD47 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >83 publications with CD47 and Immune System Diseases
 Inflammation Antibodies  >79 publications with CD47 and Inflammation
 Disease Models, Animal Antibodies  >46 publications with CD47 and Disease Models, Animal
 Anemia Antibodies  >43 publications with CD47 and Anemia
 Necrosis Antibodies  >40 publications with CD47 and Necrosis
 Nervous System Diseases Antibodies  >33 publications with CD47 and Nervous System Diseases
 Brain Diseases Antibodies  >28 publications with CD47 and Brain Diseases
 Neoplasms, Experimental Antibodies  >23 publications with CD47 and Neoplasms, Experimental
 Respiratory Tract Diseases Antibodies  >14 publications with CD47 and Respiratory Tract Diseases
 Breast Neoplasms Antibodies  >10 publications with CD47 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >427 publications with CD47 and Blood
 Vascular Antibodies  >104 publications with CD47 and Vascular
 Bone Antibodies  >75 publications with CD47 and Bone
 Bone Marrow Antibodies  >62 publications with CD47 and Bone Marrow
 Brain Antibodies  >55 publications with CD47 and Brain
 Muscle Antibodies  >54 publications with CD47 and Muscle
 Lung Antibodies  >27 publications with CD47 and Lung
 Liver Antibodies  >27 publications with CD47 and Liver
 Spleen Antibodies  >27 publications with CD47 and Spleen
 Skin Antibodies  >26 publications with CD47 and Skin
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