NP_001241679.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,572 Da
NCBI Official Full Name
T-cell differentiation antigen CD6 isoform 2
NCBI Official Synonym Full Names
CD6 molecule
NCBI Official Synonym Symbols
NCBI Protein Information
T-cell differentiation antigen CD6
UniProt Protein Name
T-cell differentiation antigen CD6
UniProt Synonym Protein Names
T12; TP120; CD_antigen: CD6
UniProt Entry Name
CD6_HUMAN
NCBI Summary for CD6
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for CD6
CD6: a type I membrane protein involved in cell adhesion. Binds to CD166. Expressed on thymocytes, peripheral T cells, a subset of B cells, and a subset of neurons. Mediates the binding of developing thymocytes with thymic epithelial cells. CD6- T cells are less autoreactive than CD6+ T cells. Phosphorylated on tyrosines and serines following T cell antigen receptor signaling. Five splice-variant isoforms have been described.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: extracellular region; immunological synapse; integral to plasma membrane; intrinsic to plasma membrane; T cell receptor complex
Molecular Function: lipopolysaccharide binding; protein binding; scavenger receptor activity
Biological Process: acute inflammatory response to antigenic stimulus; adaptive immune response; formation of immunological synapse; heterophilic cell adhesion; innate immune response; lipopolysaccharide-mediated signaling pathway; positive regulation of T cell proliferation; receptor-mediated endocytosis; response to lipopolysaccharide
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-CD6 antibody
Pathways associated with anti-CD6 antibody
Diseases associated with anti-CD6 antibody
Organs/Tissues associated with anti-CD6 antibody
|