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anti-CD6 antibody :: Rabbit anti-Human CD6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1496211
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD6, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human CD6 polyclonal Antibody

 Product Synonym Names    T12; TP120; CD6
 Product Gene Name   

anti-CD6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    186720
 3D Structure    ModBase 3D Structure for P30203
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human T-cell differentiation antigen CD6 protein (424-668aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-15910 / sc-7074 / sc-20921
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CD6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD6 antibody

   Involved in cell adhesion. Binds to CD166.
 Applications Tested/Suitable for anti-CD6 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CD6 antibody    Recommended dilution: WB:1:500-2000
IHC:1:20-1:200
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 Western Blot (WB) of anti-CD6 antibody    All lanes: CD6 antibody at 4ug/ml
Lane 1:Hela whole cell lysate
Lane 2:jurkat whole cell lysate
Lane 3:HT-29 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 72,69,64,65,59,61 kDa
Observed band size: 72 kDa

anti-CD6 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CD6 antibody    Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS1496211 at dilution 1:100
anti-CD6 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CD6 antibody    Immunohistochemistry of paraffin-embedded human thymus using MBS1496211 at dilution 1:100
anti-CD6 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD6. It may not necessarily be applicable to this product.
 NCBI GI #    363543322
 NCBI GeneID    923
 NCBI Accession #    NP_001241679.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001254750.1 [Other Products]
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 UniProt Primary Accession #    P30203 [Other Products]
 UniProt Secondary Accession #    Q9UMF2; Q9Y4K7; Q9Y4K8; Q9Y4K9; Q9Y4L0; A4KAD4; A4KAD5 [Other Products]
 UniProt Related Accession #    P30203 [Other Products]
 Molecular Weight    60,572 Da
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 NCBI Official Full Name    T-cell differentiation antigen CD6 isoform 2
 NCBI Official Synonym Full Names    CD6 molecule
 NCBI Official Symbol    CD6 [Similar Products]
 NCBI Official Synonym Symbols   
TP120
[Similar Products]
 NCBI Protein Information    T-cell differentiation antigen CD6
 UniProt Protein Name    T-cell differentiation antigen CD6
 UniProt Synonym Protein Names   
T12; TP120; CD_antigen: CD6
 Protein Family    CD63 antigen
 UniProt Gene Name    CD6 [Similar Products]
 UniProt Entry Name    CD6_HUMAN
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 NCBI Summary for CD6    This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for CD6    CD6: a type I membrane protein involved in cell adhesion. Binds to CD166. Expressed on thymocytes, peripheral T cells, a subset of B cells, and a subset of neurons. Mediates the binding of developing thymocytes with thymic epithelial cells. CD6- T cells are less autoreactive than CD6+ T cells. Phosphorylated on tyrosines and serines following T cell antigen receptor signaling. Five splice-variant isoforms have been described.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extracellular region; immunological synapse; integral to plasma membrane; intrinsic to plasma membrane; T cell receptor complex

Molecular Function: lipopolysaccharide binding; protein binding; scavenger receptor activity

Biological Process: acute inflammatory response to antigenic stimulus; adaptive immune response; formation of immunological synapse; heterophilic cell adhesion; innate immune response; lipopolysaccharide-mediated signaling pathway; positive regulation of T cell proliferation; receptor-mediated endocytosis; response to lipopolysaccharide
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 Research Articles on CD6    1. CD6 regulatory T cells are characterized by CD6 expression and FOXP3 expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD6 antibodyPathways associated with anti-CD6 antibody
 Reference Product  PubMed Publications
 CD5 antibody  >106 publications with CD6 and CD5
 CD2 antibody  >78 publications with CD6 and CD2
 ALCAM antibody  >64 publications with CD6 and ALCAM
 IRF8 antibody  >5 publications with CD6 and IRF8
 ZAP70 antibody  >4 publications with CD6 and ZAP70
 SDCBP antibody  >2 publications with CD6 and SDCBP
 MYC antibody  >1 publications with CD6 and MYC
 SYK antibody  >1 publications with CD6 and SYK
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Diseases associated with anti-CD6 antibodyOrgans/Tissues associated with anti-CD6 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >23 publications with CD6 and Inflammation
 Multiple Sclerosis Antibodies  >20 publications with CD6 and Multiple Sclerosis
 Necrosis Antibodies  >14 publications with CD6 and Necrosis
 Vascular Diseases Antibodies  >7 publications with CD6 and Vascular Diseases
 Lung Diseases Antibodies  >6 publications with CD6 and Lung Diseases
 Neoplasm Metastasis Antibodies  >6 publications with CD6 and Neoplasm Metastasis
 Male Urogenital Diseases Antibodies  >5 publications with CD6 and Male Urogenital Diseases
 Adenocarcinoma Antibodies  >5 publications with CD6 and Adenocarcinoma
 Genital Diseases, Female Antibodies  >3 publications with CD6 and Genital Diseases, Female
 Atrophy Antibodies  >2 publications with CD6 and Atrophy
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >254 publications with CD6 and Blood
 Thymus Antibodies  >26 publications with CD6 and Thymus
 Lymph Node Antibodies  >22 publications with CD6 and Lymph Node
 Spleen Antibodies  >15 publications with CD6 and Spleen
 Brain Antibodies  >14 publications with CD6 and Brain
 Intestine Antibodies  >12 publications with CD6 and Intestine
 Lung Antibodies  >10 publications with CD6 and Lung
 Eye Antibodies  >9 publications with CD6 and Eye
 Kidney Antibodies  >6 publications with CD6 and Kidney
 Thyroid Antibodies  >5 publications with CD6 and Thyroid
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