NP_005182
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted: 32 kDa Observed: 50 kDa
NCBI Official Full Name
T-lymphocyte activation antigen CD80
NCBI Official Synonym Full Names
CD80 molecule
NCBI Official Synonym Symbols
B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1 [Similar Products]
NCBI Protein Information
T-lymphocyte activation antigen CD80
UniProt Protein Name
T-lymphocyte activation antigen CD80
UniProt Synonym Protein Names
Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7; CD_antigen: CD80
UniProt Synonym Gene Names
NCBI Summary for CD80
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
UniProt Comments for CD80
CD80: Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q13.33
Cellular Component: cell surface; integral to membrane; plasma membrane
Molecular Function: phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding
Biological Process: cell-cell signaling; phosphoinositide-mediated signaling; positive regulation of peptidyl-tyrosine phosphorylation; regulation of phosphoinositide 3-kinase cascade; T cell activation; T cell costimulation
Product References and Citations for anti-CD80 antibody
1. Lane P. Regulation of T and B cell responses by modulating interactions between CD28/CTLA-4 and their ligands, CD80 and CD86. Ann NY Acad Sci 1997; 815:392-400. 2. Feucht J, Kayser S, Gorodezki D, et al. T-cell responses against CD19+ pediatric acute lymphoblastic leukemia mediated by bispecific T-cell engager (BiTE) are regulated contrarily by PD-L1 and CD80/CD86 on leukemic blasts. Oncotarget 2016; 7:76902-19.
Research Articles on CD80
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Products associated with anti-CD80 antibody
Pathways associated with anti-CD80 antibody
Diseases associated with anti-CD80 antibody
Organs/Tissues associated with anti-CD80 antibody
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