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anti-CD80 antibody :: Rabbit anti-Human CD80 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9202324
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD80, Polyclonal Antibody

★Popular Item★
 Also Known As   

CD80 Antibody (C-term)

 Product Synonym Names    T-lymphocyte activation antigen CD80; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B71; B7; CD80; CD80; CD28LG; CD28LG1; LAB7
 Product Gene Name   

anti-CD80 antibody

[Similar Products]
 Antibody/Peptide Pairs    CD80 peptide (MBS9225475) is used for blocking the activity of CD80 antibody (MBS9202324)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    260-288
 OMIM    112203
 3D Structure    ModBase 3D Structure for P33681
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Clone Number    RB22396
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This CD80 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-288 amino acids from the C-terminal region of human CD80.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Function    Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation
 Cellular location    Membrane; Single-pass type I membrane protein
 Tissue location    Expressed on activated B-cells, macrophages and dendritic cells
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 Preparation and Storage    Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-CD80 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD80 antibody

   CD80 is activation antigen B7-1 (formerly referred to as B7) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 (MIM 186760) and CTLA4 (MIM 123890) ligands of T cells.
 Product Categories/Family for anti-CD80 antibody    Immunology; Microbiology; Signal Transduction
 Applications Tested/Suitable for anti-CD80 antibody   

FC,E

 Application Notes for anti-CD80 antibody    FC~~1:10~50
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 Western Blot (WB) of anti-CD80 antibody    Western blot analysis of CD80 Antibody (C-term) in HL-60 cell line lysates (35ug/lane).CD80 (arrow) was detected using the purified Pab.
anti-CD80 antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC/FACS) of anti-CD80 antibody    CD80 Antibody (C-term) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-CD80 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for CD80. It may not necessarily be applicable to this product.
 NCBI GI #    4885123
 NCBI GeneID    941
 NCBI Accession #    NP_005182.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005191.3 [Other Products]
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 UniProt Primary Accession #    P33681 [Other Products]
 UniProt Secondary Accession #    Q5DTA9; Q5DTB0 [Other Products]
 UniProt Related Accession #    P33681 [Other Products]
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 NCBI Official Full Name    T-lymphocyte activation antigen CD80
 NCBI Official Synonym Full Names    CD80 molecule
 NCBI Official Symbol    CD80 [Similar Products]
 NCBI Official Synonym Symbols   
B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1
[Similar Products]
 NCBI Protein Information    T-lymphocyte activation antigen CD80
 UniProt Protein Name    T-lymphocyte activation antigen CD80
 UniProt Synonym Protein Names   
Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7; CD_antigen: CD80
 Protein Family    T-lymphocyte activation antigen
 UniProt Gene Name    CD80 [Similar Products]
 UniProt Synonym Gene Names    CD28LG; CD28LG1; LAB7; B7 [Similar Products]
 UniProt Entry Name    CD80_HUMAN
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 NCBI Summary for CD80    The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
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 UniProt Comments for CD80    CD80: Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 3q13.3-q21

Cellular Component: cell surface; plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; coreceptor activity

Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of signal transduction; viral reproduction; nerve growth factor receptor signaling pathway; T cell activation; positive regulation of transcription, DNA-dependent; positive regulation of interleukin-2 biosynthetic process; positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell signaling; T cell costimulation; innate immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of T-helper 1 cell differentiation
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Product References and Citations for anti-CD80 antibody

   Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)
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 Research Articles on CD80    1. SNP rs1599795 in CD80 3'-UTR, through disrupting the regulatory role of miR-132-3p, miR-212-3p, and miR-361-5p in CD80 expression, contributed to the occurrence of gastric cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD80 antibodyPathways associated with anti-CD80 antibody
 Reference Product  PubMed Publications
 CD86 antibody  >4804 publications with CD80 and CD86
 CD40 antibody  >2160 publications with CD80 and CD40
 CD28 antibody  >1823 publications with CD80 and CD28
 CTLA4 antibody  >1032 publications with CD80 and CTLA4
 HLA-A antibody  >104 publications with CD80 and HLA-A
 HLA-DRB1 antibody  >13 publications with CD80 and HLA-DRB1
 IFNG antibody  >6 publications with CD80 and IFNG
 CD8A antibody  >4 publications with CD80 and CD8A
 CD247 antibody  >1 publications with CD80 and CD247
 Products by Pathway  Pathway Diagram
 , Pathway antibodies  , Pathway Diagram
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 , Pathway antibodies  , Pathway Diagram
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 , Pathway antibodies  , Pathway Diagram
Diseases associated with anti-CD80 antibodyOrgans/Tissues associated with anti-CD80 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1133 publications with CD80 and Necrosis
 Inflammation Antibodies  >770 publications with CD80 and Inflammation
 Neoplasms, Experimental Antibodies  >387 publications with CD80 and Neoplasms, Experimental
 Lung Diseases Antibodies  >310 publications with CD80 and Lung Diseases
 Liver Diseases Antibodies  >227 publications with CD80 and Liver Diseases
 Cardiovascular Diseases Antibodies  >186 publications with CD80 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >160 publications with CD80 and Kidney Diseases
 Lung Neoplasms Antibodies  >111 publications with CD80 and Lung Neoplasms
 Liver Neoplasms Antibodies  >107 publications with CD80 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >83 publications with CD80 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6015 publications with CD80 and Blood
 Lymph Node Antibodies  >587 publications with CD80 and Lymph Node
 Lung Antibodies  >421 publications with CD80 and Lung
 Thymus Antibodies  >183 publications with CD80 and Thymus
 Tonsil Antibodies  >40 publications with CD80 and Tonsil
 Connective Tissue Antibodies  >36 publications with CD80 and Connective Tissue
 Mammary Gland Antibodies  >4 publications with CD80 and Mammary Gland
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