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anti-CD81 antibody :: Rabbit CD81 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9412232
Western Blot (WB)
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD81, Polyclonal Antibody

 Also Known As   

CD81 Polyclonal Antibody

 Product Synonym Names    CD81; TAPA1; TSPAN28; CD81 antigen; 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD81
 Product Gene Name   

anti-CD81 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    186845
 3D Structure    ModBase 3D Structure for P60033
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    CD81 Polyclonal Antibody detects endogenous levels of CD81 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Immunogen Type    peptide
 Immunogen Description    Synthesized peptide derived from the Internal region of human CD81.
 Target Name    CD81
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-CD81 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CD81 antibody    Total protein Ab
 Applications Tested/Suitable for anti-CD81 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CD81 antibody    Western Blot: 1:500 - 1:2000
ELISA: 1:20000
Not yet tested in other applications.
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 Western Blot (WB) of anti-CD81 antibody    Western Blot analysis of 4T1 cells using CD81 Polyclonal Antibody.
anti-CD81 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CD81. It may not necessarily be applicable to this product.
 NCBI GI #    663071018
 NCBI GeneID    975
 NCBI Accession #    NP_001284578.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001297649.1 [Other Products]
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 UniProt Primary Accession #    P60033 [Other Products]
 UniProt Secondary Accession #    P18582; Q5U0J6 [Other Products]
 UniProt Related Accession #    P60033 [Other Products]
 Molecular Weight    25,809 Da
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 NCBI Official Full Name    CD81 antigen isoform 2
 NCBI Official Synonym Full Names    CD81 molecule
 NCBI Official Symbol    CD81 [Similar Products]
 NCBI Official Synonym Symbols   
S5.7; CVID6; TAPA1; TSPAN28
[Similar Products]
 NCBI Protein Information    CD81 antigen
 UniProt Protein Name    CD81 antigen
 UniProt Synonym Protein Names   
26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD_antigen: CD81
 Protein Family    CD81 antigen
 UniProt Gene Name    CD81 [Similar Products]
 UniProt Synonym Gene Names    TAPA1; TSPAN28; Tspan-28 [Similar Products]
 UniProt Entry Name    CD81_HUMAN
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 NCBI Summary for CD81    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
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 UniProt Comments for CD81    CD81: May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV. Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6); also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the tetraspanin (TM4SF) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: focal adhesion; membrane; integral to plasma membrane; plasma membrane; immunological synapse; vesicle

Molecular Function: protein binding

Biological Process: virion attachment, binding of host cell surface receptor; cell proliferation; protein localization; entry of virus into host cell; regulation of immune response; positive regulation of peptidyl-tyrosine phosphorylation; activation of MAPK activity; positive regulation of 1-phosphatidylinositol 4-kinase activity; positive regulation of cell proliferation; positive regulation of B cell proliferation; phosphatidylinositol biosynthetic process; phosphatidylinositol metabolic process

Disease: Immunodeficiency, Common Variable, 6
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 Research Articles on CD81    1. These data revealed the crucial role played by His490 and His621 in hepatitis C virus infection, particularly during CD81 binding in cell entry.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD81 antibodyPathways associated with anti-CD81 antibody
 Reference Product  PubMed Publications
 CD19 antibody  >104 publications with CD81 and CD19
 SCARB1 antibody  >46 publications with CD81 and SCARB1
 IGSF8 antibody  >18 publications with CD81 and IGSF8
 CR2 antibody  >16 publications with CD81 and CR2
 PTGFRN antibody  >13 publications with CD81 and PTGFRN
 IFITM1 antibody  >3 publications with CD81 and IFITM1
 ITGA4 antibody  >2 publications with CD81 and ITGA4
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
Diseases associated with anti-CD81 antibodyOrgans/Tissues associated with anti-CD81 antibody
 Disease Name  Pubmed Publications
 Hepatitis C Antibodies  >539 publications with CD81 and Hepatitis C
 Liver Diseases Antibodies  >263 publications with CD81 and Liver Diseases
 Carcinoma Antibodies  >104 publications with CD81 and Carcinoma
 Carcinoma, Hepatocellular Antibodies  >74 publications with CD81 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >52 publications with CD81 and Liver Neoplasms
 Adenocarcinoma Antibodies  >47 publications with CD81 and Adenocarcinoma
 Liver Cirrhosis Antibodies  >45 publications with CD81 and Liver Cirrhosis
 Inflammation Antibodies  >41 publications with CD81 and Inflammation
 Vascular Diseases Antibodies  >29 publications with CD81 and Vascular Diseases
 Necrosis Antibodies  >26 publications with CD81 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >352 publications with CD81 and Blood
 Liver Antibodies  >249 publications with CD81 and Liver
 Bone Antibodies  >48 publications with CD81 and Bone
 Bone Marrow Antibodies  >42 publications with CD81 and Bone Marrow
 Brain Antibodies  >38 publications with CD81 and Brain
 Kidney Antibodies  >27 publications with CD81 and Kidney
 Lung Antibodies  >27 publications with CD81 and Lung
 Vascular Antibodies  >25 publications with CD81 and Vascular
 Muscle Antibodies  >19 publications with CD81 and Muscle
 Lymph Node Antibodies  >19 publications with CD81 and Lymph Node
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