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anti-CD86 antibody :: Rabbit anti-Mouse CD86 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175613
Western Blot (WB)
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD86, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-CD86 antibody

 Product Synonym Names    T-lymphocyte activation antigen CD86; CD86 molecule; Activation B7-2 antigen 3 antibody; Activation B7-2 antigen antibody; B-lymphocyte activation antigen B7-2 2 antibody; B-lymphocyte activation antigen B7-2 antibody; B7 2 antibody; B7 antibody; B7-2 antibody; B7.2 antibody; B70 antibody; B72 antigen antibody; BU63 antibody; CD28 antigen ligand 2 2 antibody; CD28 antigen ligand 2 antibody; Cd28l2 antibody; CD28LG2 antibody; CD86 antibody; CD86 antigen(CD28 antigen ligand 2, B7-2 antigen) 1, 2 antibody; CD86 antigen(CD28 antigen ligand 2, B7-2 antigen) antibody; CD86 antigen antibody; CD86 molecule antibody; CD86_HUMAN antibody; CLS1 antibody; CTLA-4 counter-receptor B7.2 2, 3 antibody; CTLA-4 counter-receptor B7.2 antibody; Early T-cell costimulatory molecule 1 antibody; ETC-1 antibody; FUN 1 antibody; FUN-1 antibody; LAB72 antibody; Ly-58 antibody; Ly58 antibody; MB7 antibody; MB7-2 antibody; Membrane glycoprotein antibody; MGC34413 antibody; T-lymphocyte activation antigen CD86 antibody; TS/A-2 antibody
 Product Gene Name   

anti-CD86 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P42082
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    No cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the N-terminus of mouse CD86 (66-80aa YEHYLGTEKLDSVNA), different from the related rat sequence by two amino acids.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CD86 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD86 antibody

   Description: Rabbit IgG polyclonal antibody for T-lymphocyte activation antigen CD86(CD86) detection. Tested with WB in Mouse.
Background: CD86 is officially called Cluster of Differentiation 86, also known as B7-2. Being a member of the immunoglobulin superfamily, it is a protein expressed on antigen-presenting cells. The CD86 gene is mapped to human chromosome 3q21. The smallest transcript, 828 bp, which the authors termed CD86deltaTM, has a deletion from nucleotide 686 to nucleotide 829(i.e., exon 6) and encodes a 275-amino acid protein. CD86deltaTM enhances proliferation and cytokine production by both naive and memory T cells, providing costimulatory signals necessary for T cell activation and survival.
 Applications Tested/Suitable for anti-CD86 antibody   

Western Blot (WB)

 Application Notes for anti-CD86 antibody    Western Blot:
Concentration: 0.1-0.5ug/ml
Tested Species: MS
Predicted Species: -
Antigen Retrieval: -

Tested Species: In-house tested species with positive results.
Predicted Species: Specices predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.
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 Western Blot (WB) of anti-CD86 antibody    Anti-CD86 antibody, MBS175613, Western blotting
Lane 1: Recombinant Mouse CD86 Protein 10ng
Lane 2: Recombinant Mouse CD86 Protein 5ng
Lane 3: Recombinant Mouse CD86 Protein 2.5ng
anti-CD86 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CD86. It may not necessarily be applicable to this product.
 NCBI GI #    1168852
 NCBI GeneID    12524
 NCBI Accession #    P42082.1 [Other Products]
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 UniProt Primary Accession #    P42082 [Other Products]
 UniProt Related Accession #    P42082 [Other Products]
 Molecular Weight    33,962 Da
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 NCBI Official Full Name    T-lymphocyte activation antigen CD86
 NCBI Official Synonym Full Names    CD86 antigen
 NCBI Official Symbol    Cd86 [Similar Products]
 NCBI Official Synonym Symbols   
B7; B70; MB7; B7-2; B7.2; CLS1; Ly58; ETC-1; Ly-58; MB7-2; Cd28l2; TS/A-2
[Similar Products]
 NCBI Protein Information    T-lymphocyte activation antigen CD86; activation B7-2 antigen; early T cell costimulatory molecule-1; early T-cell costimulatory molecule 1
 UniProt Protein Name    T-lymphocyte activation antigen CD86
 UniProt Synonym Protein Names   
Activation B7-2 antigen; Early T-cell costimulatory molecule 1; ETC-1; CD_antigen: CD86
 Protein Family    T-lymphocyte activation antigen
 UniProt Gene Name    Cd86 [Similar Products]
 UniProt Synonym Gene Names    ETC-1 [Similar Products]
 UniProt Entry Name    CD86_MOUSE
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 UniProt Comments for CD86    CD86: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Cellular Component: cell surface; intracellular membrane-bound organelle; membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: receptor binding

Biological Process: B cell activation; negative regulation of T cell anergy; immune system process; toll-like receptor signaling pathway; positive regulation of T cell proliferation; positive regulation of activated T cell proliferation; defense response to virus
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 Research Articles on CD86    1. novel function of CTLA4Ig in tumor immunity and suggest that CD86 on NK cells is an activating receptor and closely involved in the CTLA4Ig-mediated anti-tumor response.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD86 antibodyDiseases associated with anti-CD86 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
 CD28 Dependent Vav1 Pathway antibodies  CD28 Dependent Vav1 Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1133 publications with CD86 and Necrosis
 Inflammation Antibodies  >805 publications with CD86 and Inflammation
 Nervous System Diseases Antibodies  >280 publications with CD86 and Nervous System Diseases
 Lung Diseases Antibodies  >271 publications with CD86 and Lung Diseases
 Neoplasms, Experimental Antibodies  >202 publications with CD86 and Neoplasms, Experimental
 Liver Diseases Antibodies  >189 publications with CD86 and Liver Diseases
 Cardiovascular Diseases Antibodies  >176 publications with CD86 and Cardiovascular Diseases
 Brain Diseases Antibodies  >147 publications with CD86 and Brain Diseases
 Dermatitis, Contact Antibodies  >107 publications with CD86 and Dermatitis, Contact
 Kidney Diseases Antibodies  >87 publications with CD86 and Kidney Diseases
Organs/Tissues associated with anti-CD86 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >1050 publications with CD86 and Bone Marrow
 Spleen Antibodies  >686 publications with CD86 and Spleen
 Lymph Node Antibodies  >642 publications with CD86 and Lymph Node
 Skin Antibodies  >447 publications with CD86 and Skin
 Lung Antibodies  >349 publications with CD86 and Lung
 Liver Antibodies  >275 publications with CD86 and Liver
 Thymus Antibodies  >121 publications with CD86 and Thymus
 Uncharacterized Tissue Antibodies  >3 publications with CD86 and Uncharacterized Tissue
 Mammary Gland Antibodies  >1 publications with CD86 and Mammary Gland
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