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anti-CD8A antibody :: Rabbit anti-Human CD8A / CD8 Alpha Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS247657
Immunohistochemistry (IHC)
Unit / Price
0.125 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD8A / CD8 Alpha, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal [clone P17-V] to Human CD8A / CD8 Alpha

 Product Synonym Names    Anti-CD8A / CD8 Alpha Antibody (C-Terminus, clone P17-V) IHC-plus; CD8A; CD8a molecule; CD8a antigen; OKT8 T-cell antigen; Leu2 T-lymphocyte antigen; T8 T-cell antigen; T cell co-receptor; p32; CD8; Leu2; T-cell antigen Leu2; CD8 Alpha; Human CD8A; CD8 Alpha
 Product Gene Name   

anti-CD8A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 608957
 3D Structure    ModBase 3D Structure for P01732
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 Clonality    Polyclonal
 Clone Number    P17-V
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human CD8
 Purity/Purification    Purified
 Form/Format    20 mM Tris-HCl, pH 8.0, 20 mg/ml BSA, 0.05% sodium azide
 Concentration    2.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Peptide derived from C-terminal region of human CD8.
 Immunogen    CD8A / CD8 Alpha antibody was raised against peptide derived from C-terminal region of human CD8.
 Antigen Modification    C-Terminus
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 Preparation and Storage    Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-CD8A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD8A antibody

   The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain.
 Applications Tested/Suitable for anti-CD8A antibody   

Immunohistochemistry (IHC - Paraffin; IHC - Frozen)

 Application Notes for anti-CD8A antibody    IHC-Fr (1:100 - 1:200), IHC-P (1:25 - 1:100)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-CD8A antibody    Anti-CD8A antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:25.
anti-CD8A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD8A. It may not necessarily be applicable to this product.
 NCBI GI #    22902134
 NCBI GeneID    925
 NCBI Accession #    NP_001759.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001768.6 [Other Products]
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 UniProt Primary Accession #    P01732 [Other Products]
 UniProt Secondary Accession #    Q13970; Q4ZG17; B4DT80; D6W5M8 [Other Products]
 UniProt Related Accession #    P01732 [Other Products]
 Molecular Weight    30,214 Da
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 NCBI Official Full Name    T-cell surface glycoprotein CD8 alpha chain isoform 1
 NCBI Official Synonym Full Names    CD8a molecule
 NCBI Official Symbol    CD8A [Similar Products]
 NCBI Official Synonym Symbols   
CD8; MAL; p32; Leu2
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte antigen; CD8 antigen, alpha polypeptide (p32); T-lymphocyte differentiation antigen T8/Leu-2
 UniProt Protein Name    T-cell surface glycoprotein CD8 alpha chain
 UniProt Synonym Protein Names   
T-lymphocyte differentiation antigen T8/Leu-2; CD_antigen: CD8a
 Protein Family    T-cell surface glycoprotein
 UniProt Gene Name    CD8A [Similar Products]
 UniProt Synonym Gene Names    MAL [Similar Products]
 UniProt Entry Name    CD8A_HUMAN
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 NCBI Summary for CD8A    The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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 UniProt Comments for CD8A    CD8A: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane; extracellular region; external side of plasma membrane

Molecular Function: protein binding; protein homodimerization activity; MHC class I protein binding; coreceptor activity; protein kinase binding

Biological Process: antigen processing and presentation; regulation of immune response; T cell activation; T cell mediated immunity; cytotoxic T cell differentiation; positive regulation of calcium-mediated signaling; immune response; defense response to virus; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Cd8 Deficiency, Familial
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 Research Articles on CD8A    1. We suggest that unique set of interactions between CEACAM5, CD1d, and CD8 render CD1d more class I-like molecule, facilitating antigen presentation and activation of CD8(+)-suppressor regulatory T cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD8A antibodyPathways associated with anti-CD8A antibody
 Reference Product  PubMed Publications
 CD4 antibody  >81 publications with CD8A and CD4
 CD8B antibody  >21 publications with CD8A and CD8B
 CD3E antibody  >7 publications with CD8A and CD3E
 CD3D antibody  >4 publications with CD8A and CD3D
 HLA-A antibody  >4 publications with CD8A and HLA-A
 LCK antibody  >3 publications with CD8A and LCK
 HLA-B antibody  >1 publications with CD8A and HLA-B
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with anti-CD8A antibodyOrgans/Tissues associated with anti-CD8A antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >18 publications with CD8A and Inflammation
 Necrosis Antibodies  >12 publications with CD8A and Necrosis
 Cardiovascular Diseases Antibodies  >9 publications with CD8A and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >8 publications with CD8A and Neoplasms, Experimental
 Carcinoma Antibodies  >7 publications with CD8A and Carcinoma
 Liver Diseases Antibodies  >7 publications with CD8A and Liver Diseases
 Kidney Diseases Antibodies  >5 publications with CD8A and Kidney Diseases
 Fibrosis Antibodies  >4 publications with CD8A and Fibrosis
 Liver Neoplasms Antibodies  >3 publications with CD8A and Liver Neoplasms
 Heart Diseases Antibodies  >3 publications with CD8A and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >101 publications with CD8A and Blood
 Spleen Antibodies  >24 publications with CD8A and Spleen
 Liver Antibodies  >16 publications with CD8A and Liver
 Thymus Antibodies  >14 publications with CD8A and Thymus
 Kidney Antibodies  >12 publications with CD8A and Kidney
 Brain Antibodies  >10 publications with CD8A and Brain
 Intestine Antibodies  >9 publications with CD8A and Intestine
 Lung Antibodies  >6 publications with CD8A and Lung
 Heart Antibodies  >3 publications with CD8A and Heart
 Connective Tissue Antibodies  >2 publications with CD8A and Connective Tissue
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