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anti-CD98 antibody :: Rabbit CD98 LIGHT CHAIN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS221428
Testing Data #1
Unit / Price
0.05 mg  /  $725 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD98 LIGHT CHAIN, Polyclonal Antibody

 Also Known As   

RABBIT ANTI HUMAN CD98 LIGHT CHAIN (N-TERMINAL)

 Product Gene Name   

anti-CD98 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600182
 3D Structure    ModBase 3D Structure for Q01650
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
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 Specificity    This item detects an epitope within the N-terminal (NT) region of the CD98 light chain (CD98LC), also known as the 4F2 light chain, or LAT-1. CD98LC is a 40kD multi-pass membrane protein which forms a heterodimer with the CD98 heavy chain to allow transport of large branched chain, neutral amino acids into the cell. This transport system leads to the uptake of seven amino acids, including isoleucine, phenylalanine, and methionine.

The expression levels of CD98LC are upregulated in a wide spectrum of primary human cancers. Changes in amino acid transporter expression are thought to be an early change in oncogenesis, as they impart growth and survival advantages.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.1% Sodium Azide (NaN3)
 Immunogen    Synthetic peptide: N-terminal region of CD98 light chain
Histology Positive Control Tissue
 Antiserum Preparation    Antisera to CD98 light chain were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD98 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD98 antibody

   MBS221428 detects an epitope within the N-terminal (NT) region of the CD98 light chain (CD98LC), also known as the 4F2 light chain, or LAT-1. CD98LC is a 40kD multi-pass membrane protein which forms a heterodimer with the CD98 heavy chain to allow transport of large branched chain, neutral amino acids into the cell. This transport system leads to the uptake of seven amino acids, including isoleucine, phenylalanine, and methionine. The expression levels of CD98LC are upregulated in a wide spectrum of primary human cancers. Changes in amino acid transporter expression are thought to be an early change in oncogenesis, as they impart growth and survival advantages.
 Applications Tested/Suitable for anti-CD98 antibody   

Immunohistology Paraffin*, Western Blot (WB)

 Application Notes for anti-CD98 antibody    Western Blot: This item detects a band of approximately 50-55kDa in human liver cell lysates.
Immunohistology - Paraffin: Minimum Dilution: 15; Maximum Dilution: 25ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 1; Maximum Dilution: 10ug/ml
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 Testing Data #1 of anti-CD98 antibody    Staining of formalin fixed, paraffin embedded human placenta with Rabbit anti Human CD95 light chain (MBS221428)
anti-CD98 antibody Testing Data #1 image
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NCBI/Uniprot data below describe general gene information for CD98. It may not necessarily be applicable to this product.
 NCBI GI #    71979932
 NCBI GeneID    8140
 NCBI Accession #    NP_003477.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_003486.5 [Other Products]
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 UniProt Primary Accession #    Q01650 [Other Products]
 UniProt Secondary Accession #    Q8IV97; Q9UBN8; Q9UP15; Q9UQC0 [Other Products]
 UniProt Related Accession #    Q01650 [Other Products]
 Molecular Weight    55,010 Da
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 NCBI Official Full Name    large neutral amino acids transporter small subunit 1
 NCBI Official Synonym Full Names    solute carrier family 7 (amino acid transporter light chain, L system), member 5
 NCBI Official Symbol    SLC7A5 [Similar Products]
 NCBI Official Synonym Symbols   
E16; CD98; LAT1; 4F2LC; MPE16; hLAT1; D16S469E
[Similar Products]
 NCBI Protein Information    large neutral amino acids transporter small subunit 1; 4F2 LC; 4F2 light chain; CD98 light chain; L-type amino acid transporter 1; integral membrane protein E16; large neutral amino acids transporter 1; sodium-independent neutral amino acid transporter LAT1; solute carrier family 7 (cationic amino acid transporter, y+ system), member 5; solute carrier family 7 member 5; y+ system cationic amino acid transporter
 UniProt Protein Name    Large neutral amino acids transporter small subunit 1
 UniProt Synonym Protein Names   
4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter
 UniProt Gene Name    SLC7A5 [Similar Products]
 UniProt Synonym Gene Names    CD98LC; LAT1; MPE16; 4F2 LC; 4F2LC; hLAT1 [Similar Products]
 UniProt Entry Name    LAT1_HUMAN
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 UniProt Comments for CD98    SLC7A5: Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood- brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L- leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts. Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc. Expression induced in quiescent peripheral blood lymphocytes after treatment with phorbol myristate acetate (PMA) and phytohemagglutinin (PHA). Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore. Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: membrane; intracellular membrane-bound organelle; cytoplasm; apical plasma membrane; nucleolus; integral to membrane; plasma membrane; nucleus; cytosol

Molecular Function: L-amino acid transmembrane transporter activity; peptide antigen binding; neutral amino acid transmembrane transporter activity; amino acid transmembrane transporter activity

Biological Process: neutral amino acid transport; amino acid metabolic process; nervous system development; transport; amino acid transport; ion transport; cell differentiation; blood coagulation; leukocyte migration; transmembrane transport
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 Research Articles on CD98    1. L-type amino acid transporter 1 expression increases in well-differentiated but decreases in poorly differentiated endometrial endometrioid adenocarcinoma and shows an inverse correlation with p53 expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD98 antibodyPathways associated with anti-CD98 antibody
 Reference Product  PubMed Publications
 SLC3A2 antibody  >17 publications with CD98 and SLC3A2
 SLC1A5 antibody  >15 publications with CD98 and SLC1A5
 SLC3A1 antibody  >1 publications with CD98 and SLC3A1
 Products by Pathway  Pathway Diagram
 Amino Acid Transport Across The Plasma Membrane Pathway antibodies  Amino Acid Transport Across The Plasma Membrane Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram
Diseases associated with anti-CD98 antibodyOrgans/Tissues associated with anti-CD98 antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >28 publications with CD98 and Adenocarcinoma
 Lung Neoplasms Antibodies  >22 publications with CD98 and Lung Neoplasms
 Nervous System Diseases Antibodies  >21 publications with CD98 and Nervous System Diseases
 Brain Diseases Antibodies  >20 publications with CD98 and Brain Diseases
 Lung Diseases Antibodies  >20 publications with CD98 and Lung Diseases
 Breast Neoplasms Antibodies  >14 publications with CD98 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >10 publications with CD98 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >8 publications with CD98 and Liver Neoplasms
 Ovarian Neoplasms Antibodies  >8 publications with CD98 and Ovarian Neoplasms
 Cardiovascular Diseases Antibodies  >7 publications with CD98 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >67 publications with CD98 and Blood
 Brain Antibodies  >54 publications with CD98 and Brain
 Lung Antibodies  >26 publications with CD98 and Lung
 Kidney Antibodies  >26 publications with CD98 and Kidney
 Liver Antibodies  >17 publications with CD98 and Liver
 Muscle Antibodies  >16 publications with CD98 and Muscle
 Eye Antibodies  >12 publications with CD98 and Eye
 Lymph Antibodies  >12 publications with CD98 and Lymph
 Lymph Node Antibodies  >11 publications with CD98 and Lymph Node
 Prostate Antibodies  >9 publications with CD98 and Prostate
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