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anti-CD98 antibody :: Rabbit CD98 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9413980
Western Blot (WB)
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD98, Polyclonal Antibody

★Popular Item★
 Also Known As   

CD98 Polyclonal Antibody

 Product Synonym Names    SLC3A2; MDU1; 4F2 cell-surface antigen heavy chain; 4F2hc; 4F2 heavy chain antigen; Lymphocyte activation antigen 4F2 large subunit; CD98
 Product Gene Name   

anti-CD98 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    158070
 3D Structure    ModBase 3D Structure for P08195
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    CD98 Polyclonal Antibody detects endogenous levels of CD98 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Immunogen Type    peptide
 Immunogen Description    Synthesized peptide derived from the C-terminal region of human CD98.
 Target Name    CD98
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-CD98 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CD98 antibody    Total protein Ab
 Applications Tested/Suitable for anti-CD98 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CD98 antibody    Western Blot: 1:500 - 1:2000
ELISA: 1:10000
Not yet tested in other applications.
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 Western Blot (WB) of anti-CD98 antibody    Western Blot analysis of HEB cells using CD98 Polyclonal Antibody
anti-CD98 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CD98. It may not necessarily be applicable to this product.
 NCBI GI #    61744477
 NCBI GeneID    6520
 NCBI Accession #    NP_001012680.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001012662.2 [Other Products]
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 UniProt Primary Accession #    P08195 [Other Products]
 UniProt Secondary Accession #    Q13543 [Other Products]
 UniProt Related Accession #    P08195 [Other Products]
 Molecular Weight    69kd
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 NCBI Official Full Name    4F2 cell-surface antigen heavy chain isoform b
 NCBI Official Synonym Full Names    solute carrier family 3 (amino acid transporter heavy chain), member 2
 NCBI Official Symbol    SLC3A2 [Similar Products]
 NCBI Official Synonym Symbols   
4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC
[Similar Products]
 NCBI Protein Information    4F2 cell-surface antigen heavy chain
 UniProt Protein Name    4F2 cell-surface antigen heavy chain
 UniProt Synonym Protein Names   
4F2 heavy chain antigen; Lymphocyte activation antigen 4F2 large subunit; Solute carrier family 3 member 2; CD_antigen: CD98
 UniProt Gene Name    SLC3A2 [Similar Products]
 UniProt Synonym Gene Names    MDU1; 4F2hc [Similar Products]
 UniProt Entry Name    4F2_HUMAN
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 NCBI Summary for CD98    This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]
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 UniProt Comments for CD98    SLC3A2: a transmembrane solute carrier protein that transports L-type amino acids and regulates intracellular calcium levels. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. Disulfide-linked heterodimer of a glycosylated heavy chain and a non-glycosylated light chain (SLC7A5, SLC7A6, SLCA7A7, SLC7A8, SLC7A10 or SLCA7A11). Colocalizes with cadherins. Interacts with FAM57A and ICAM1. Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1. Expression is induced in resting peripheral blood T- lymphocytes following PHA stimulation. Expression increases at the time of maximal DNA synthesi, in fibroblasts stimulated to divide. Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore. Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid- trimester stage. Belongs to the SLC3A transporter family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: nucleoplasm; cell surface; membrane; cytoplasm; apical plasma membrane; melanosome; plasma membrane; integral to membrane; nucleus

Molecular Function: cation binding; protein binding; neutral amino acid transmembrane transporter activity; double-stranded RNA binding; catalytic activity; calcium:sodium antiporter activity

Biological Process: response to exogenous dsRNA; amino acid transport; calcium ion transport; carbohydrate metabolic process; ion transport; blood coagulation; cell growth; leukocyte migration; transmembrane transport; tryptophan transport
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 Research Articles on CD98    1. data suggest that genetic variation of rs1059292 in CD98 gene may affect clinical outcome of NSCLC in Chinese population
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD98 antibodyPathways associated with anti-CD98 antibody
 Reference Product  PubMed Publications
 SLC7A5 antibody  >19 publications with CD98 and SLC7A5
 SLC7A8 antibody  >7 publications with CD98 and SLC7A8
 SLC7A11 antibody  >7 publications with CD98 and SLC7A11
 SLC7A7 antibody  >6 publications with CD98 and SLC7A7
 SLC7A6 antibody  >6 publications with CD98 and SLC7A6
 FAM57A antibody  >1 publications with CD98 and FAM57A
 Products by Pathway  Pathway Diagram
 Amino Acid Transport Across The Plasma Membrane Pathway antibodies  Amino Acid Transport Across The Plasma Membrane Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram
Diseases associated with anti-CD98 antibody
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >5 publications with CD98 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with CD98 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >3 publications with CD98 and Disease Models, Animal
 Kidney Diseases Antibodies  >3 publications with CD98 and Kidney Diseases
 Inflammation Antibodies  >2 publications with CD98 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >2 publications with CD98 and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >2 publications with CD98 and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >1 publications with CD98 and Neoplasm Metastasis
 Cardiovascular Diseases Antibodies  >1 publications with CD98 and Cardiovascular Diseases
 Heart Diseases Antibodies  >1 publications with CD98 and Heart Diseases
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