Q9UNH5.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Dual specificity protein phosphatase CDC14A
NCBI Official Synonym Full Names
cell division cycle 14A
NCBI Protein Information
dual specificity protein phosphatase CDC14A; CDC14 cell division cycle 14 homolog A; CDC10 (cell division cycle 10, S. cerevisiae, homolog)
UniProt Protein Name
Dual specificity protein phosphatase CDC14A
UniProt Synonym Protein Names
CDC14 cell division cycle 14 homolog A
UniProt Entry Name
CC14A_HUMAN
NCBI Summary for CDC14A
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for CDC14A
CDC14A: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC- FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.3.48; EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 1p21
Cellular Component: nucleoplasm; centrosome; cytoplasm; spindle; nucleus
Molecular Function: protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activity
Biological Process: cell proliferation; cell division; cell cycle
Research Articles on CDC14A
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Products associated with anti-CDC14A antibody
Pathways associated with anti-CDC14A antibody
Diseases associated with anti-CDC14A antibody
Organs/Tissues associated with anti-CDC14A antibody
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