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anti-cdc2 antibody :: Rabbit CDC2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS627828 anti-cdc2 antibody
Unit / Price
0.05 mg  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDC2, Polyclonal Antibody

 Also Known As   

CDC2, phosphorylated (Thr161) (Cell Division Protein Kinase 1, Cell Division Control Protein 2 Homolog, Cyclin-dependent Kinase 1, CDK1, p34 Protein Kinase, CDK1)

 Product Synonym Names    Anti -CDC2, phosphorylated (Thr161) (Cell Division Protein Kinase 1, Cell Division Control Protein 2 Homolog, Cyclin-dependent Kinase 1, CDK1, p34 Protein Kinase, CDK1)
 Product Gene Name   

anti-cdc2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2L; NT_033779.4 (10384739..10386263, complement). Location: 31D11-31D11
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes endogenous levels of human cdc2 only when phosphorylated at Thr161. Species Cross-Reactivity: mouse, rat.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
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 Immunogen    Synthetic phosphopeptide corresponding to human CDC2 around the phosphorylation site of threonine161 (T-Y-pT-H-E).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-cdc2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-cdc2 antibody

   Entry of all eukaryotic cells into M-phase of the cell cycle is regulated by activation of cdc2 kinase. Activation of cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. The critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of tyrosine 15 and threonine 14. Phosphorylation at Tyr15 and inhibition of cdc2 is carried out by Wee1 and Myt1 protein kinases. Tyr15 dephosphorylation and activation of cdc2 is carried out by the cdc25 phosphatase. cdc2 activation requires phosphorylation at Thr161, which is attributed to the cdk-activating kinase CAK, a complex of cdk7 and cyclin H. Phosphorylation at Thr161 is also required for association with cyclin A.
 Product Categories/Family for anti-cdc2 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-cdc2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-cdc2 antibody    Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
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NCBI/Uniprot data below describe general gene information for cdc2. It may not necessarily be applicable to this product.
 NCBI GI #    17136606
 NCBI GeneID    34411
 NCBI Accession #    NP_476797.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_057449.3 [Other Products]
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 NCBI Official Full Name    cdc2
 NCBI Official Symbol    cdc2 [Similar Products]
 NCBI Official Synonym Symbols   
5363; cdc; Cdc2; CDC2; cdc2Dm; CDCDm; cdk1; Cdk1; CDK1; CDK1/CDC2; CG5363; Dcdc2; Dm cdc2; Dmcdc2; DmCdc2; DmCdk1; DmelCG5363; group 4; l(2)31Eh
[Similar Products]
 NCBI Protein Information    CG5363 gene product from transcript CG5363-RA; cdc2; CG5363-PA; cdc2-PA; cyclin-dependent kinase 1; CDC2 kinase; cyclin dependent kinase
 Protein Family    CDC25-like phosphatase
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 Research Articles on cdc2    1. Based on the results obtained, it was presupposed that distribution of annulate lamellae containing cytoplasmic pores could reflect the inactivation of the mitotic kinase cdk1 in Drosophila syncytial embryos.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-cdc2 antibodyPathways associated with anti-cdc2 antibody
 Reference Product  PubMed Publications
 CycE antibody  >7 publications with cdc2 and CycE
 CycD antibody  >5 publications with cdc2 and CycD
 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-cdc2 antibodyOrgans/Tissues associated with anti-cdc2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1764 publications with cdc2 and Neoplasms
 Carcinoma Antibodies  >691 publications with cdc2 and Carcinoma
 Breast Neoplasms Antibodies  >293 publications with cdc2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >232 publications with cdc2 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >183 publications with cdc2 and Neoplasms, Experimental
 Drug Toxicity Antibodies  >173 publications with cdc2 and Drug Toxicity
 Cell Transformation, Neoplastic Antibodies  >167 publications with cdc2 and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >154 publications with cdc2 and Nervous System Diseases
 Immune System Diseases Antibodies  >146 publications with cdc2 and Immune System Diseases
 Colorectal Neoplasms Antibodies  >145 publications with cdc2 and Colorectal Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with cdc2 and Bone
 Connective Tissue Antibodies  >4 publications with cdc2 and Connective Tissue
 Heart Antibodies  >3 publications with cdc2 and Heart
 Muscle Antibodies  >3 publications with cdc2 and Muscle
 Brain Antibodies  >3 publications with cdc2 and Brain
 Vascular Antibodies  >2 publications with cdc2 and Vascular
 Embryonic Tissue Antibodies  >2 publications with cdc2 and Embryonic Tissue
 Ear Antibodies  >1 publications with cdc2 and Ear
 Kidney Antibodies  >1 publications with cdc2 and Kidney
 Umbilical Cord Antibodies  >1 publications with cdc2 and Umbilical Cord
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