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anti-CDC6 antibody :: Rabbit anti-Human CDC6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7051040
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDC6, Polyclonal Antibody

★Popular Item★
 Also Known As   

CDC6 Antibody

 Product Synonym Names    Cell division control protein 6 homolog; CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6; CDC6; CDC18L
 Product Gene Name   

anti-CDC6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    U77949 mRNA
 3D Structure    ModBase 3D Structure for Q99741
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Cell division control protein 6 homolog protein (1-141AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-32507 / sc-8341
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CDC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CDC6 antibody

   Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
 Applications Tested/Suitable for anti-CDC6 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CDC6 antibody    WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
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 Western Blot (WB) of anti-CDC6 antibody    Western Blot
Positive WB detected in: HepG2 whole cell lysate,Jurkat whole cell lysate,RAW264.7 whole cell lysate,Raji whole cell lysate
All lanes: CDC6 antibody at 2.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 63 KDa
Observed band size: 63 KDa

anti-CDC6 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CDC6 antibody    Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MBS7051040 at dilution of 1:100
anti-CDC6 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CDC6 antibody    Immunohistochemistry of paraffin-embedded human ovarian cancer using MBS7051040 at dilution of 1:100
anti-CDC6 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CDC6. It may not necessarily be applicable to this product.
 NCBI GI #    4502703
 NCBI GeneID    990
 NCBI Accession #    NP_001245.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001254.3 [Other Products]
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 UniProt Primary Accession #    Q99741 [Other Products]
 UniProt Secondary Accession #    Q8TB30 [Other Products]
 UniProt Related Accession #    Q99741 [Other Products]
 Molecular Weight    62,720 Da
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 NCBI Official Full Name    cell division control protein 6 homolog
 NCBI Official Synonym Full Names    cell division cycle 6
 NCBI Official Symbol    CDC6 [Similar Products]
 NCBI Official Synonym Symbols   
CDC18L; HsCDC6; MGORS5; HsCDC18
[Similar Products]
 NCBI Protein Information    cell division control protein 6 homolog
 UniProt Protein Name    Cell division control protein 6 homolog
 UniProt Synonym Protein Names   
CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6
 Protein Family    Cell division control protein
 UniProt Gene Name    CDC6 [Similar Products]
 UniProt Synonym Gene Names    CDC18L; HsCdc18; HsCDC6 [Similar Products]
 UniProt Entry Name    CDC6_HUMAN
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 NCBI Summary for CDC6    The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CDC6    CDC6: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Belongs to the CDC6/cdc18 family.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 17q21.3

Cellular Component: cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus; spindle midzone; spindle pole

Molecular Function: kinase binding; nucleotide binding; protein binding

Biological Process: DNA replication; DNA replication checkpoint; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; negative regulation of cell proliferation; negative regulation of DNA replication; positive regulation of chromosome segregation; positive regulation of cytokinesis; regulation of cyclin-dependent protein kinase activity; regulation of mitotic metaphase/anaphase transition; traversing start control point of mitotic cell cycle

Disease: Meier-gorlin Syndrome 5
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 Research Articles on CDC6    1. The data demonstrate that Cdc6 serves as a regulator of ribosomal DNA transcription initiation, and indicate a mechanism by which initiation of ribosomal DNA transcription and DNA replication can be coordinated in cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDC6 antibodyPathways associated with anti-CDC6 antibody
 Reference Product  PubMed Publications
 CDT1 antibody  >136 publications with CDC6 and CDT1
 MCM2 antibody  >119 publications with CDC6 and MCM2
 ORC1 antibody  >103 publications with CDC6 and ORC1
 CDK2 antibody  >78 publications with CDC6 and CDK2
 MCM7 antibody  >52 publications with CDC6 and MCM7
 CDK1 antibody  >34 publications with CDC6 and CDK1
 MCM5 antibody  >31 publications with CDC6 and MCM5
 ORC2 antibody  >31 publications with CDC6 and ORC2
 MCM3 antibody  >25 publications with CDC6 and MCM3
 ORC5 antibody  >8 publications with CDC6 and ORC5
 Products by Pathway  Pathway Diagram
 Activation Of ATR In Response To Replication Stress Pathway antibodies  Activation Of ATR In Response To Replication Stress Pathway Diagram
 Activation Of The Pre-replicative Complex Pathway antibodies  Activation Of The Pre-replicative Complex Pathway Diagram
 Assembly Of The Pre-replicative Complex Pathway antibodies  Assembly Of The Pre-replicative Complex Pathway Diagram
 Association Of Licensing Factors With The Pre-replicative Complex Pathway antibodies  Association Of Licensing Factors With The Pre-replicative Complex Pathway Diagram
 CDC6 Association With The ORC:origin Complex Pathway antibodies  CDC6 Association With The ORC:origin Complex Pathway Diagram
 CDK-mediated Phosphorylation And Removal Of Cdc6 Pathway antibodies  CDK-mediated Phosphorylation And Removal Of Cdc6 Pathway Diagram
 CDT1 Association With The CDC6:ORC:origin Complex Pathway antibodies  CDT1 Association With The CDC6:ORC:origin Complex Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
Diseases associated with anti-CDC6 antibodyOrgans/Tissues associated with anti-CDC6 antibody
 Disease Name  Pubmed Publications
 Ataxia Antibodies  >20 publications with CDC6 and Ataxia
 Prostatic Neoplasms Antibodies  >15 publications with CDC6 and Prostatic Neoplasms
 Cell Transformation, Neoplastic Antibodies  >15 publications with CDC6 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >14 publications with CDC6 and Breast Neoplasms
 Lung Neoplasms Antibodies  >12 publications with CDC6 and Lung Neoplasms
 Meier-Gorlin syndrome Antibodies  >10 publications with CDC6 and Meier-Gorlin syndrome
 Neoplasm Metastasis Antibodies  >8 publications with CDC6 and Neoplasm Metastasis
 Carcinoma, Hepatocellular Antibodies  >8 publications with CDC6 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >7 publications with CDC6 and Liver Diseases
 Nervous System Diseases Antibodies  >7 publications with CDC6 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >26 publications with CDC6 and Lung
 Blood Antibodies  >20 publications with CDC6 and Blood
 Prostate Antibodies  >20 publications with CDC6 and Prostate
 Bone Antibodies  >20 publications with CDC6 and Bone
 Muscle Antibodies  >11 publications with CDC6 and Muscle
 Lymph Node Antibodies  >10 publications with CDC6 and Lymph Node
 Lymph Antibodies  >10 publications with CDC6 and Lymph
 Liver Antibodies  >9 publications with CDC6 and Liver
 Vascular Antibodies  >7 publications with CDC6 and Vascular
 Cervix Antibodies  >6 publications with CDC6 and Cervix
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