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anti-CDC7 antibody :: Rabbit CDC7 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2525257
Testing Data
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDC7, Polyclonal Antibody

 Also Known As   

CDC7 Antibody

 Product Synonym Names    CDC7L1; HsCDC7; Hsk1; MGC117361; MGC126237; MGC126238; huCDC7
 Product Gene Name   

anti-CDC7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603311
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
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 Immunogen    Fusion protein of CDC7
 Calculated Molecular Weight: 574aa; 64kd
Observed Molecular Weight: 64kd
  
 Buffer    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7519 / sc-7518 / sc-13010
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 Other Notes    Small volumes of anti-CDC7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CDC7 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-CDC7 antibody    WB: 1:500-1:5000
IF: 1:20-1:50
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 Testing Data of anti-CDC7 antibody    anti-CDC7 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CDC7. It may not necessarily be applicable to this product.
 NCBI GI #    2345156
 NCBI GeneID    8317
 NCBI Accession #    AAC52080.1 [Other Products]
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 UniProt Secondary Accession #    O00558; Q5T5U5; D3DT31 [Other Products]
 UniProt Related Accession #    O00311 [Other Products]
 Molecular Weight    63,888 Da
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 NCBI Official Full Name    Cdc7
 NCBI Official Synonym Full Names    cell division cycle 7
 NCBI Official Symbol    CDC7 [Similar Products]
 NCBI Official Synonym Symbols   
Hsk1; CDC7L1; HsCDC7; huCDC7
[Similar Products]
 NCBI Protein Information    cell division cycle 7-related protein kinase; CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; CDC7-related kinase; cell division cycle 7 homolog; cell division cycle 7-like protein 1
 UniProt Protein Name    Cell division cycle 7-related protein kinase
 Protein Family    Cell division control protein
 UniProt Gene Name    CDC7 [Similar Products]
 UniProt Synonym Gene Names    CDC7L1; CDC7-related kinase; HsCdc7; huCdc7 [Similar Products]
 UniProt Entry Name    CDC7_HUMAN
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 NCBI Summary for CDC7    This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]
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 UniProt Comments for CDC7    CDC7: an evolutionarily conserved serine/threonine protein kinase of the CDC7 family. Predominantly localized in the nucleus, it plays a pivotal role in linking cell cycle regulation to genome duplication, being essential for the firing of DNA replication origins. Plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. The human protein requires phosphorylation by CDK1 at T376 and binding to activator of S-phase kinase (ASK)/DBF4B to be fully activated. The interaction between Cdc7 and DBFK subunits facilitates ATP binding and substrate recognition by the Cdc7 kinase. Although CDC7 expression levels appear to be constant throughout the cell cycle, the expression levels of DBF4B is cell cycle-regulated. Thus, the CDC7 activity is activated during S phase in eukaryotes. The Cdc7/ DBF4B complex regulates initiation of DNA replication by phosphorylating chromatin-bound mini-chromosome maintenance protein 2 (MCM2). Impaired Cdc7 kinase activity leads to S-phase arrest. Plays a role in the TGF-beta regulation of smooth muscle cell (SMC) differentiation. Interacts with Smad3 to facilitate Smad3 binding to SMC marker promoter, leading to the activation of SMC marker gene transcription.

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; Other group; CDC7 family

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: microtubule cytoskeleton; nucleoplasm; intercellular bridge; cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; kinase activity; ATP binding; protein kinase activity

Biological Process: regulation of cell shape; peptidyl-serine phosphorylation; DNA replication initiation; cell division; positive regulation of cell proliferation; mitotic cell cycle; DNA replication; phagocytosis; double-strand break repair via break-induced replication; G1/S transition of mitotic cell cycle
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 Research Articles on CDC7    1. The interaction between Claspin and Cdc7 is not dependent on Cdc7 kinase activity, but Claspin interaction with the DNA helicase subunit Mcm2 is lost upon Cdc7 inhibition.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDC7 antibodyPathways associated with anti-CDC7 antibody
 Reference Product  PubMed Publications
 DBF4 antibody  >168 publications with CDC7 and DBF4
 MCM2 antibody  >74 publications with CDC7 and MCM2
 CDC45 antibody  >53 publications with CDC7 and CDC45
 MCM4 antibody  >25 publications with CDC7 and MCM4
 MCM5 antibody  >21 publications with CDC7 and MCM5
 MCM7 antibody  >16 publications with CDC7 and MCM7
 MCM10 antibody  >9 publications with CDC7 and MCM10
 MCM3 antibody  >7 publications with CDC7 and MCM3
 Products by Pathway  Pathway Diagram
 Activation Of ATR In Response To Replication Stress Pathway antibodies  Activation Of ATR In Response To Replication Stress Pathway Diagram
 Activation Of The Pre-replicative Complex Pathway antibodies  Activation Of The Pre-replicative Complex Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
Diseases associated with anti-CDC7 antibodyOrgans/Tissues associated with anti-CDC7 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >4 publications with CDC7 and Disease Models, Animal
 Skin Neoplasms Antibodies  >3 publications with CDC7 and Skin Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with CDC7 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >3 publications with CDC7 and Breast Neoplasms
 Inflammation Antibodies  >2 publications with CDC7 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >2 publications with CDC7 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >2 publications with CDC7 and Lung Neoplasms
 Liver Diseases Antibodies  >1 publications with CDC7 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with CDC7 and Carcinoma, Hepatocellular
 Liver Neoplasms, Experimental Antibodies  >1 publications with CDC7 and Liver Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with CDC7 and Blood
 Eye Antibodies  >7 publications with CDC7 and Eye
 Lung Antibodies  >4 publications with CDC7 and Lung
 Skin Antibodies  >3 publications with CDC7 and Skin
 Testis Antibodies  >3 publications with CDC7 and Testis
 Bone Marrow Antibodies  >2 publications with CDC7 and Bone Marrow
 Kidney Antibodies  >2 publications with CDC7 and Kidney
 Lymph Node Antibodies  >2 publications with CDC7 and Lymph Node
 Heart Antibodies  >2 publications with CDC7 and Heart
 Thyroid Antibodies  >1 publications with CDC7 and Thyroid
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