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anti-CDCA8 antibody :: Rabbit CDCA8 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151409
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDCA8, Polyclonal Antibody

 Also Known As   

CDCA8 Antibody

 Product Synonym Names    CDCA8; BOR; DasraB; MESRGP; BOREALIN; PESCRG3; Borealin; Cell division cycle-associated protein 8; hDasra-B; cell division cycle associated 8
 Product Gene Name   

anti-CDCA8 antibody

[Similar Products]
 Antibody/Peptide Pairs    CDCA8 peptide (MBS152863) is used for blocking the activity of CDCA8 antibody (MBS151409)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609977
 3D Structure    ModBase 3D Structure for Q53HL2
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    CDCA8 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    CDCA8 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of the human CDCA8.
 Buffer    CDCA8 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    CDCA8 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-CDCA8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CDCA8 antibody

   CDCA8 Antibody: CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.
 Applications Tested/Suitable for anti-CDCA8 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-CDCA8 antibody    CDCA8 antibody can be used for detection of CDCA8 by Western blot at 1 and 2 mug/mL. Antibody can also be used for immunoflourescence starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-CDCA8 antibody    Western blot analysis of CDCA8 in Rat kidney lysate with CDCA8 antibody at (A) 1 and (B) 2 μg/mL.
anti-CDCA8 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-CDCA8 antibody    Immunofluorescence of CDCA8 in rat kidney tissue with CDCA8 antibody at 20 μg/mL.
anti-CDCA8 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CDCA8. It may not necessarily be applicable to this product.
 NCBI GI #    8922438
 NCBI GeneID    55143
 NCBI Accession #    NP_060571 [Other Products]
 NCBI GenBank Nucleotide #    NM_018101.3 [Other Products]
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 UniProt Primary Accession #    Q53HL2 [Other Products]
 UniProt Secondary Accession #    Q53HN1; Q96AM3; Q9NVW5; D3DPT4 [Other Products]
 UniProt Related Accession #    Q53HL2 [Other Products]
 Molecular Weight    31,323 Da
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 NCBI Official Full Name    borealin
 NCBI Official Synonym Full Names    cell division cycle associated 8
 NCBI Official Symbol    CDCA8 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    borealin; Dasra B; dasra-B; hDasra-B; cell division cycle-associated protein 8; pluripotent embryonic stem cell-related gene 3 protein
 UniProt Protein Name    Borealin
 UniProt Synonym Protein Names   
Cell division cycle-associated protein 8; Dasra-B; hDasra-B; Pluripotent embryonic stem cell-related gene 3 protein
 UniProt Gene Name    CDCA8 [Similar Products]
 UniProt Synonym Gene Names    PESCRG3; hDasra-B [Similar Products]
 UniProt Entry Name    BOREA_HUMAN
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 NCBI Summary for CDCA8    This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]
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 UniProt Comments for CDCA8    Borealin: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. Belongs to the borealin family.

Protein type: Cell cycle regulation; Nucleolus

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: intercellular bridge; protein complex; nucleolus; spindle; midbody; nucleus; cytosol; chromosome, pericentric region; chromocenter

Molecular Function: protein binding

Biological Process: cell division; mitotic cell cycle; mitotic metaphase plate congression; chromosome organization and biogenesis
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 Research Articles on CDCA8    1. Borealin interacts directly with the Snf7 components of ESCRT-III in human cells.the Borealin central region encompassing residues 110-207 was both necessary & sufficient to bind to CHMP4C.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDCA8 antibodyPathways associated with anti-CDCA8 antibody
 Reference Product  PubMed Publications
 BIRC5 antibody  >26 publications with CDCA8 and BIRC5
 INCENP antibody  >24 publications with CDCA8 and INCENP
 AURKB antibody  >24 publications with CDCA8 and AURKB
 KIF2C antibody  >3 publications with CDCA8 and KIF2C
 CENPF antibody  >1 publications with CDCA8 and CENPF
 KIF20A antibody  >1 publications with CDCA8 and KIF20A
 PLK1 antibody  >1 publications with CDCA8 and PLK1
 CDC20 antibody  >1 publications with CDCA8 and CDC20
 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 Resolution Of Sister Chromatid Cohesion Pathway antibodies  Resolution Of Sister Chromatid Cohesion Pathway Diagram
 Separation Of Sister Chromatids Pathway antibodies  Separation Of Sister Chromatids Pathway Diagram
Diseases associated with anti-CDCA8 antibodyOrgans/Tissues associated with anti-CDCA8 antibody
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >2 publications with CDCA8 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with CDCA8 and Cell Transformation, Neoplastic
 Ovarian Neoplasms Antibodies  >2 publications with CDCA8 and Ovarian Neoplasms
 Lung Neoplasms Antibodies  >2 publications with CDCA8 and Lung Neoplasms
 Anemia Antibodies  >1 publications with CDCA8 and Anemia
 Adenocarcinoma Antibodies  >1 publications with CDCA8 and Adenocarcinoma
 Uterine Cervical Neoplasms Antibodies  >1 publications with CDCA8 and Uterine Cervical Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with CDCA8 and Blood
 Lung Antibodies  >2 publications with CDCA8 and Lung
 Stomach Antibodies  >2 publications with CDCA8 and Stomach
 Uterus Antibodies  >2 publications with CDCA8 and Uterus
 Embryonic Tissue Antibodies  >2 publications with CDCA8 and Embryonic Tissue
 Bone Antibodies  >1 publications with CDCA8 and Bone
 Cervix Antibodies  >1 publications with CDCA8 and Cervix
 Vascular Antibodies  >1 publications with CDCA8 and Vascular
 Bone Marrow Antibodies  >1 publications with CDCA8 and Bone Marrow
 Spleen Antibodies  >1 publications with CDCA8 and Spleen
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