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anti-CDCP1 antibody :: Goat CDCP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421514
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDCP1, Polyclonal Antibody

 Also Known As   

Goat anti-CDCP1 (isoform 1: C term) Antibody

 Product Synonym Names    CDCP1; CUB domain containing protein 1; HGNC: 24357; CD318; SIMA135; TRASK; CUB domain-containing protein 1; transmembrane and associated with src kinases; CDCP1 antibody; CUB domain containing protein 1 antibody; HGNC: 24357 antibody; CD318 antibody; SIMA135 antibody; TRASK antibody; CUB domain-containing protein 1 antibody; transmembrane and associated with src kinases antibody; CDCP1 (isoform 1: C term)
 Product Gene Name   

anti-CDCP1 antibody

[Similar Products]
 Antibody/Peptide Pairs    CDCP1 peptide (MBS427039) is used for blocking the activity of CDCP1 antibody (MBS421514)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    PLLNTQEPME PAE
 OMIM    611735
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-PLLNTQEPMEPAE, from the C Terminus of the protein sequence according to NP_073753.3.
 Epitope    C Terminus
 Note    This antibody is expected to recognize isoform 1 (NP_073753.3) only.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CDCP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CDCP1 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

 Application Notes for anti-CDCP1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: This antibody has been successfully used in IHC for human endometrium.
Immunoprecipitation: This antibody has been successfully used in IP with A549 cells.
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 Western Blot (WB) of anti-CDCP1 antibody    (1ug/ml) staining of Human Colon lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-CDCP1 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-CDCP1 antibody    HEK293 overexpressing CDCP1 (RC220633) and probed (mock transfection in first lane), tested by Origene.
anti-CDCP1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CDCP1. It may not necessarily be applicable to this product.
 NCBI GI #    30410805
 NCBI GeneID    64866
 NCBI Accession #    NP_073753.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_022842.4 [Other Products]
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 UniProt Secondary Accession #    Q49UB4; Q6NT71; Q6U9Y2; Q8WU91; Q96QU7; Q9H676; Q9H8C2 [Other Products]
 UniProt Related Accession #    Q9H5V8 [Other Products]
 Molecular Weight    37,818 Da
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 NCBI Official Full Name    CUB domain-containing protein 1 isoform 1
 NCBI Official Synonym Full Names    CUB domain containing protein 1
 NCBI Official Symbol    CDCP1 [Similar Products]
 NCBI Official Synonym Symbols   
CD318; TRASK; SIMA135
[Similar Products]
 NCBI Protein Information    CUB domain-containing protein 1
 UniProt Protein Name    CUB domain-containing protein 1
 UniProt Synonym Protein Names   
Membrane glycoprotein gp140; Subtractive immunization M plus HEp3-associated 135 kDa protein; SIMA135; Transmembrane and associated with src kinases; CD_antigen: CD318
 Protein Family    CUB domain-containing protein
 UniProt Gene Name    CDCP1 [Similar Products]
 UniProt Synonym Gene Names    TRASK; SIMA135 [Similar Products]
 UniProt Entry Name    CDCP1_HUMAN
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 NCBI Summary for CDCP1    This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
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 UniProt Comments for CDCP1    CDCP1: a transmembrane protein containing three extracellular CUB domains involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation depending upon its phosphorylation status. Interacts with N- and P-cadherin, syndecans 1 and 4, the serine protease ST14, SRC and PKCG. Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Its expression level is correlated with the metastatic ability of carcinoma cells. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. Three alternatively spliced human isoforms have been reported. Isoform 1 is a single-pass membrane protein that may also be shed, giving rise to a soluble peptide. Isoform 3 is secreted.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: extracellular region; integral to membrane; plasma membrane

Molecular Function: protein binding
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 Research Articles on CDCP1    1. CDCP1 overexpression enhances HER2 activity. CDCP1 binds to HER2, promoting SRC-HER2 crosstalk.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDCP1 antibodyDiseases associated with anti-CDCP1 antibody
 Reference Product  PubMed Publications
 SRC antibody  >45 publications with CDCP1 and SRC
 FYN antibody  >3 publications with CDCP1 and FYN
 ST14 antibody  >2 publications with CDCP1 and ST14
 PRKCD antibody  >2 publications with CDCP1 and PRKCD
 PRKCQ antibody  >1 publications with CDCP1 and PRKCQ
 MMP14 antibody  >1 publications with CDCP1 and MMP14
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >32 publications with CDCP1 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >17 publications with CDCP1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >15 publications with CDCP1 and Breast Neoplasms
 Neoplasm Invasiveness Antibodies  >14 publications with CDCP1 and Neoplasm Invasiveness
 Neoplasms, Experimental Antibodies  >12 publications with CDCP1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >11 publications with CDCP1 and Lung Diseases
 Prostatic Diseases Antibodies  >10 publications with CDCP1 and Prostatic Diseases
 Ovarian Neoplasms Antibodies  >5 publications with CDCP1 and Ovarian Neoplasms
 Ovarian Diseases Antibodies  >5 publications with CDCP1 and Ovarian Diseases
 Mammary Neoplasms, Animal Antibodies  >2 publications with CDCP1 and Mammary Neoplasms, Animal
Organs/Tissues associated with anti-CDCP1 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >22 publications with CDCP1 and Lung
 Blood Antibodies  >11 publications with CDCP1 and Blood
 Prostate Antibodies  >10 publications with CDCP1 and Prostate
 Kidney Antibodies  >6 publications with CDCP1 and Kidney
 Embryonic Tissue Antibodies  >5 publications with CDCP1 and Embryonic Tissue
 Vascular Antibodies  >4 publications with CDCP1 and Vascular
 Lymph Node Antibodies  >4 publications with CDCP1 and Lymph Node
 Brain Antibodies  >4 publications with CDCP1 and Brain
 Skin Antibodies  >3 publications with CDCP1 and Skin
 Pancreas Antibodies  >2 publications with CDCP1 and Pancreas
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