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anti-CDH3 antibody :: Rabbit anti-Human, Mouse CDH3 / P-Cadherin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS248856
Unit / Price
0.2 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDH3 / P-Cadherin, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human CDH3 / P-Cadherin

 Product Synonym Names    Anti-CDH3 / P-Cadherin Antibody (N-Terminus) IHC-plus; CDH3; Cadherin-3; HJMD; P-cadherin; CDHP; PCAD; Placental cadherin; Human CDH3; P-Cadherin
 Product Gene Name   

anti-CDH3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 601553
 3D Structure    ModBase 3D Structure for P22223
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS with 0.09% (w/v) sodium azide
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 Target Species    Human
 Immunogen Description    Synthetic peptide located between amino acids 114 and 142 of P22223.
 Immunogen    CDH3 / P-Cadherin antibody was raised against synthetic peptide located between amino acids 114 and 142 of P22223.
 Antigen Modification    N-Terminus
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of anti-CDH3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CDH3 antibody

   CDH3, a classical cadherin, is an integral membrane, calcium-dependent glycoprotein that mediates cell-cell interactions. The protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Alterations in the CDH3 gene have been linked to hypotrichosis with juvenile macular dystrophy (HJMD), and aberrant expression of CDH3 protein has been associated with several types of malignancies, including prostate and breast carcinomas.
 Product Categories/Family for anti-CDH3 antibody    Family: Cadherin
 Applications Tested/Suitable for anti-CDH3 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Flow Cytometry (FC/FACS)

 Application Notes for anti-CDH3 antibody    Flo (1:10 - 1:50), IHC-P (10 ug/ml), WB (1:1000)
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 Immunohistochemistry (IHC) of anti-CDH3 antibody    Anti-CDH3 / P-Cadherin antibody IHC staining of human pancreatic duct. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-CDH3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CDH3 antibody    Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with CDH3 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-CDH3 antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC/FACS) of anti-CDH3 antibody    Flow cytometry of NCI-H292 cells using CDH3 Antibody (N-term) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-CDH3 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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 Western Blot (WB) of anti-CDH3 antibody    Western blot of CDH3 Antibody (N-term) in NIH-3T3 cell line lysates (35 ug/lane). CDH3 (arrow) was detected using the purified Pab.
anti-CDH3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CDH3. It may not necessarily be applicable to this product.
 NCBI GI #    14589891
 NCBI GeneID    1001
 NCBI Accession #    NP_001784.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001793.4 [Other Products]
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 UniProt Primary Accession #    P22223 [Other Products]
 UniProt Secondary Accession #    Q05DI6; B2R6F4 [Other Products]
 UniProt Related Accession #    P22223 [Other Products]
 Molecular Weight    86,552 Da
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 NCBI Official Full Name    cadherin-3 preproprotein
 NCBI Official Synonym Full Names    cadherin 3, type 1, P-cadherin (placental)
 NCBI Official Symbol    CDH3 [Similar Products]
 NCBI Official Synonym Symbols   
CDHP; HJMD; PCAD
[Similar Products]
 NCBI Protein Information    cadherin-3; calcium-dependent adhesion protein, placental
 UniProt Protein Name    Cadherin-3
 UniProt Synonym Protein Names   
Placental cadherin; P-cadherin
 UniProt Gene Name    CDH3 [Similar Products]
 UniProt Synonym Gene Names    CDHP; P-cadherin [Similar Products]
 UniProt Entry Name    CADH3_HUMAN
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 NCBI Summary for CDH3    This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CDH3    CDH3: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cell-cell adherens junction; cytoplasm; integral to membrane; plasma membrane

Molecular Function: calcium ion binding

Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; response to drug; intercellular junction assembly and maintenance; wound healing; positive regulation of melanin biosynthetic process; Wnt receptor signaling pathway through beta-catenin; retinal homeostasis; negative regulation of transforming growth factor-beta2 production; hair cycle process; cell-cell adhesion; positive regulation of monophenol monooxygenase activity; negative regulation of catagen; visual perception; keratinization; homophilic cell adhesion; cell adhesion

Disease: Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome; Hypotrichosis, Congenital, With Juvenile Macular Dystrophy
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 Research Articles on CDH3    1. Positive N-cadherin and P-cadherin expression closely correlated with clinicopathological and biological behaviors, and poor-prognosis of gallbladder cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Rabbit Polyclonal to Human CDH3 / P-Cadherin
 Catalog #  Product Name
 MBS248856  Rabbit Polyclonal to Human CDH3 / P-Cadherin
Products associated with anti-CDH3 antibodyPathways associated with anti-CDH3 antibody
 Reference Product  PubMed Publications
 CDH1 antibody  >21 publications with CDH3 and CDH1
 CTNNB1 antibody  >4 publications with CDH3 and CTNNB1
 Products by Pathway  Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
Diseases associated with anti-CDH3 antibodyOrgans/Tissues associated with anti-CDH3 antibody
 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >28 publications with CDH3 and Skin Diseases
 Gastrointestinal Diseases Antibodies  >15 publications with CDH3 and Gastrointestinal Diseases
 Breast Neoplasms Antibodies  >13 publications with CDH3 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with CDH3 and Neoplasms, Experimental
 Adenoma Antibodies  >4 publications with CDH3 and Adenoma
 Neoplasm Metastasis Antibodies  >4 publications with CDH3 and Neoplasm Metastasis
 Ectodermal dysplasia, ectrodactyly, and macular dystrophy Antibodies  >4 publications with CDH3 and Ectodermal dysplasia, ectrodactyly, and macular dystrophy
 Inflammation Antibodies  >3 publications with CDH3 and Inflammation
 Lung Neoplasms Antibodies  >3 publications with CDH3 and Lung Neoplasms
 Lung Diseases Antibodies  >3 publications with CDH3 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >7 publications with CDH3 and Skin
 Intestine Antibodies  >5 publications with CDH3 and Intestine
 Lung Antibodies  >5 publications with CDH3 and Lung
 Liver Antibodies  >5 publications with CDH3 and Liver
 Stomach Antibodies  >4 publications with CDH3 and Stomach
 Eye Antibodies  >4 publications with CDH3 and Eye
 Blood Antibodies  >4 publications with CDH3 and Blood
 Embryonic Tissue Antibodies  >4 publications with CDH3 and Embryonic Tissue
 Thyroid Antibodies  >3 publications with CDH3 and Thyroid
 Placenta Antibodies  >2 publications with CDH3 and Placenta
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