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anti-CDK4 antibody :: CDK4-T172 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9126724
Western Blot
Unit / Price
0.05 mL  /  $265 +1 FREE 8GB USB
0.1 mL  /  $380 +1 FREE 8GB USB
0.2 mL  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDK4-T172, Polyclonal Antibody

★Popular Item★
 Also Known As   

Phospho-CDK4-T172

 Product Gene Name   

anti-CDK4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 609048
 3D Structure    ModBase 3D Structure for P11802
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 Clonality    Polyclonal
 Isotype    IgG
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
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 Source    Rabbit
 Antibody Type    Primary antibody
 Immunogen    A phospho specific peptide corresponding to residues surrounding T172 of human CDK4
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at -20 degre C
Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-CDK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CDK4 antibody

   The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
 Product Categories/Family for anti-CDK4 antibody    Phosphorylation
 Applications Tested/Suitable for anti-CDK4 antibody   

Western Blot (WB)

 Application Notes for anti-CDK4 antibody    WB: 1:500-1:2000
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 Western Blot of anti-CDK4 antibody    Western Blot analysis of extracts of various cell lines, using Phospho-CDK4-T172
anti-CDK4 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for CDK4. It may not necessarily be applicable to this product.
 NCBI GI #    1168867
 NCBI GeneID    1019
 NCBI Accession #    P11802.2 [Other Products]
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 UniProt Primary Accession #    P11802 [Other Products]
 UniProt Secondary Accession #    O00576; Q6FG61; B2R9A0; B4DNF9 [Other Products]
 UniProt Related Accession #    P11802 [Other Products]
 Molecular Weight    34kDa
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 NCBI Official Full Name    Cyclin-dependent kinase 4
 NCBI Official Synonym Full Names    cyclin-dependent kinase 4
 NCBI Official Symbol    CDK4 [Similar Products]
 NCBI Official Synonym Symbols   
CMM3; PSK-J3
[Similar Products]
 NCBI Protein Information    cyclin-dependent kinase 4; cell division protein kinase 4
 UniProt Protein Name    Cyclin-dependent kinase 4
 UniProt Synonym Protein Names   
Cell division protein kinase 4; PSK-J3
 Protein Family    Cyclin-dependent kinase
 UniProt Gene Name    CDK4 [Similar Products]
 UniProt Entry Name    CDK4_HUMAN
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 NCBI Summary for CDK4    The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CDK4    CDK4: a protein kinase of the CDK family that is important for cell cycle G1 phase progression. Its activity is restricted to the G1-S phase. Controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). Phosphorylates the retinoblastoma gene product (Rb). Point mutations found in somatic and familial melanoma. Amplified in sarcomas, glioma and lymphoma. Amplified, methylated or deleted in head and neck squamous cell carcinoma. Overexpression drives epithelial tumors in mice. Disruption makes mice resistant to cancer. Inhibitor: PD332991.

Protein type: EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; Cell cycle regulation; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK4 subfamily; CDK/CDK4 subfamily

Chromosomal Location of Human Ortholog: 12q14

Cellular Component: nucleoplasm; transcription factor complex; nuclear membrane; tight junction; perinuclear region of cytoplasm; nucleolus; cyclin-dependent protein kinase holoenzyme complex; nucleus; chromatin; cytosol

Molecular Function: protein binding; cyclin binding; cyclin-dependent protein kinase activity; protein complex binding; cyclin-dependent protein kinase regulator activity; ATP binding

Biological Process: circadian rhythm; lens development in camera-type eye; response to drug; establishment and/or maintenance of chromatin architecture; organ regeneration; positive regulation of cell size; positive regulation of translation; positive regulation of apoptosis; response to toxin; response to testosterone stimulus; signal transduction; protein amino acid phosphorylation; positive regulation of fibroblast proliferation; response to hyperoxia; regulation of gene expression; cell division; response to lead ion; positive regulation of cell proliferation; mitotic cell cycle; regulation of protein kinase activity; G1/S transition of mitotic cell cycle

Disease: Melanoma, Cutaneous Malignant, Susceptibility To, 3
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 Research Articles on CDK4    1. In the subsequent molecular experiments, western blot analysis and kinase activity detection demonstrated that TAMs can significantly boost the expression levels and activities of CDK2 and CDK4 in SKOV3 cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDK4 antibodyPathways associated with anti-CDK4 antibody
 Reference Product  PubMed Publications
 CCND1 antibody  >2039 publications with CDK4 and CCND1
 CDKN2A antibody  >1007 publications with CDK4 and CDKN2A
 CDKN1A antibody  >763 publications with CDK4 and CDKN1A
 CDKN1B antibody  >670 publications with CDK4 and CDKN1B
 CCND3 antibody  >152 publications with CDK4 and CCND3
 CCND2 antibody  >145 publications with CDK4 and CCND2
 RB1 antibody  >81 publications with CDK4 and RB1
 CCNE1 antibody  >35 publications with CDK4 and CCNE1
 CDC37 antibody  >31 publications with CDK4 and CDC37
 CCNA2 antibody  >31 publications with CDK4 and CCNA2
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-CDK4 antibodyOrgans/Tissues associated with anti-CDK4 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >786 publications with CDK4 and Carcinoma
 Adenocarcinoma Antibodies  >308 publications with CDK4 and Adenocarcinoma
 Breast Neoplasms Antibodies  >305 publications with CDK4 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >237 publications with CDK4 and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >229 publications with CDK4 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >214 publications with CDK4 and Neoplasms, Experimental
 Skin Neoplasms Antibodies  >208 publications with CDK4 and Skin Neoplasms
 Lung Neoplasms Antibodies  >170 publications with CDK4 and Lung Neoplasms
 Liver Diseases Antibodies  >168 publications with CDK4 and Liver Diseases
 Liver Neoplasms Antibodies  >159 publications with CDK4 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >420 publications with CDK4 and Blood
 Lung Antibodies  >288 publications with CDK4 and Lung
 Liver Antibodies  >280 publications with CDK4 and Liver
 Skin Antibodies  >278 publications with CDK4 and Skin
 Muscle Antibodies  >271 publications with CDK4 and Muscle
 Brain Antibodies  >269 publications with CDK4 and Brain
 Vascular Antibodies  >216 publications with CDK4 and Vascular
 Bone Antibodies  >174 publications with CDK4 and Bone
 Prostate Antibodies  >153 publications with CDK4 and Prostate
 Kidney Antibodies  >111 publications with CDK4 and Kidney
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