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anti-CDK5R1 antibody :: Rabbit anti-Human, mouse CDK5R1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9213336
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDK5R1, Polyclonal Antibody

★Popular Item★
 Also Known As   

CDK5R1 Antibody (N-term)

 Product Synonym Names    Cyclin-dependent kinase 5 activator 1; CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit; Cyclin-dependent kinase 5 activator 1; p35; p35; Cyclin-dependent kinase 5 activator 1; p25; p25; Tau protein kinase II 23 kDa subunit; p23; CDK5R1; CDK5R; NCK5A
 Product Gene Name   

anti-CDK5R1 antibody

[Similar Products]
 Antibody/Peptide Pairs    CDK5R1 peptide (MBS9230056) is used for blocking the activity of CDK5R1 antibody (MBS9213336)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603460
 3D Structure    ModBase 3D Structure for Q15078
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Specificity    This CDK5R1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 30-64 amino acids from the N-terminal region of human CDK5R1.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.309 (lot specific)
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 Cellular Location    Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals
 Tissue Location    Brain and neuron specific.
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-CDK5R1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CDK5R1 antibody

   p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
 Product Categories/Family for anti-CDK5R1 antibody    Cell Biology; Neuroscience; Signal Transduction
 Applications Tested/Suitable for anti-CDK5R1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CDK5R1 antibody    WB~~1:2000
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 Western Blot (WB) of anti-CDK5R1 antibody    All lanes : Anti-CDK5R1 Antibody (N-term) at 1:2000 dilution
Lane 1: human cerebellum lysates
Lane 2: mouse brain lysates

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution

Predicted band size : 34 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
anti-CDK5R1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CDK5R1. It may not necessarily be applicable to this product.
 NCBI GI #    4502737
 NCBI GeneID    8851
 NCBI Accession #    NP_003876.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003885.2 [Other Products]
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 UniProt Primary Accession #    Q15078 [Other Products]
 UniProt Secondary Accession #    Q5U0G3; E1P664 [Other Products]
 UniProt Related Accession #    Q15078 [Other Products]
 Molecular Weight    34060
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 NCBI Official Full Name    cyclin-dependent kinase 5 activator 1
 NCBI Official Synonym Full Names    cyclin-dependent kinase 5, regulatory subunit 1 (p35)
 NCBI Official Symbol    CDK5R1 [Similar Products]
 NCBI Official Synonym Symbols   
p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a
[Similar Products]
 NCBI Protein Information    cyclin-dependent kinase 5 activator 1
 UniProt Protein Name    Cyclin-dependent kinase 5 activator 1
 UniProt Synonym Protein Names   
Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit
 Protein Family    Cyclin-dependent kinase 5 activator
 UniProt Gene Name    CDK5R1 [Similar Products]
 UniProt Synonym Gene Names    CDK5R; NCK5A; CDK5 activator 1; p35; p25; p23 [Similar Products]
 UniProt Entry Name    CD5R1_HUMAN
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 NCBI Summary for CDK5R1    The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CDK5R1    CDK5R1: activator of cyclin-dependent kinase 5 (CDK5). Required for proper development of the central nervous system. The p35 form of this protein is cleaved by calpain, generating a p25 form, resulting in the prolonged activation and relocalization of the CDK5 from the cell periphery to nuclear and perinuclear regions. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease, leading to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

Protein type: Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: contractile fiber; intracellular membrane-bound organelle; cyclin-dependent protein kinase 5 activator complex; postsynaptic density; dendrite; dendritic spine; cytosol; nucleoplasm; growth cone; cell soma; membrane; axon; perinuclear region of cytoplasm; cytoplasm; plasma membrane; neuromuscular junction; nucleus

Molecular Function: protein serine/threonine kinase activator activity; protein binding; ephrin receptor binding; cyclin-dependent protein kinase activity; cadherin binding; cyclin-dependent protein kinase 5 activator activity; kinase activity; calcium ion binding; protein kinase binding; protein kinase activity

Biological Process: superior olivary nucleus maturation; axon guidance; regulation of neuron differentiation; rhythmic process; neuron migration; negative regulation of axon extension; neuron differentiation; positive regulation of neuron apoptosis; ephrin receptor signaling pathway; cerebellum development; neuron adhesion; neurite development; layer formation in the cerebral cortex; serine phosphorylation of STAT3 protein; acetylcholine receptor signaling, muscarinic pathway; hippocampus development; peptidyl-threonine phosphorylation; axonal fasciculation; cell proliferation; peptidyl-serine phosphorylation; embryonic development; ionotropic glutamate receptor signaling pathway; regulation of actin cytoskeleton organization and biogenesis; regulation of cyclin-dependent protein kinase activity; brain development; negative regulation of transcription, DNA-dependent
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Product References and Citations for anti-CDK5R1 antibody

   Tsai L.-H.,et al.Nature 371:419-423(1994).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Patrick G.N.,et al.Nature 402:615-622(1999).
Kerokoski P.,et al.Brain Res. Mol. Brain Res. 106:50-56(2002).
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 Research Articles on CDK5R1    1. Cdk5/p35 is required for motor learning and involved in long-term synaptic plasticity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDK5R1 antibodyPathways associated with anti-CDK5R1 antibody
 Reference Product  PubMed Publications
 CDK5 antibody  >114 publications with CDK5R1 and CDK5
 PPP1R1B antibody  >2 publications with CDK5R1 and PPP1R1B
 CAPN2 antibody  >1 publications with CDK5R1 and CAPN2
 CDK5RAP1 antibody  >1 publications with CDK5R1 and CDK5RAP1
 GSK3B antibody  >1 publications with CDK5R1 and GSK3B
 Products by Pathway  Pathway Diagram
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Diseases associated with anti-CDK5R1 antibodyOrgans/Tissues associated with anti-CDK5R1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >51 publications with CDK5R1 and Nervous System Diseases
 Brain Diseases Antibodies  >41 publications with CDK5R1 and Brain Diseases
 Cardiovascular Diseases Antibodies  >9 publications with CDK5R1 and Cardiovascular Diseases
 Inflammation Antibodies  >7 publications with CDK5R1 and Inflammation
 Nerve Degeneration Antibodies  >6 publications with CDK5R1 and Nerve Degeneration
 Learning Disorders Antibodies  >6 publications with CDK5R1 and Learning Disorders
 Kidney Diseases Antibodies  >5 publications with CDK5R1 and Kidney Diseases
 Memory Disorders Antibodies  >5 publications with CDK5R1 and Memory Disorders
 Cognition Disorders Antibodies  >4 publications with CDK5R1 and Cognition Disorders
 Neurobehavioral Manifestations Antibodies  >4 publications with CDK5R1 and Neurobehavioral Manifestations
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >85 publications with CDK5R1 and Brain
 Embryonic Tissue Antibodies  >9 publications with CDK5R1 and Embryonic Tissue
 Kidney Antibodies  >9 publications with CDK5R1 and Kidney
 Eye Antibodies  >4 publications with CDK5R1 and Eye
 Muscle Antibodies  >4 publications with CDK5R1 and Muscle
 Lung Antibodies  >3 publications with CDK5R1 and Lung
 Pancreas Antibodies  >2 publications with CDK5R1 and Pancreas
 Ovary Antibodies  >1 publications with CDK5R1 and Ovary
 Uterus Antibodies  >1 publications with CDK5R1 and Uterus
 Liver Antibodies  >1 publications with CDK5R1 and Liver
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