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anti-CDKN1B antibody :: Rabbit CDKN1B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS125745
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDKN1B, Polyclonal Antibody

★Popular Item★
 Also Known As   

CDKN1B Polyclonal Antibody

 Product Synonym Names    CDKN1B; CDKN4; KIP1; MEN1B; MEN4; P27KIP1
 Product Gene Name   

anti-CDKN1B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 610755
 3D Structure    ModBase 3D Structure for P46527
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
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 Calculated MW    22kDa
 Immunogen    Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human CDKN1B (NP_004055.1)
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at -20C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-CDKN1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CDKN1B antibody

   This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
 Product Categories/Family for anti-CDKN1B antibody    Polyclonal
 Applications Tested/Suitable for anti-CDKN1B antibody   

Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

 Application Notes for anti-CDKN1B antibody    Western Blot (WB) 1:500 - 1:2000
Immunohistochemistry (IHC): 1:50-1:200
Immunofluorescence (IF)IF 1:20-1:50
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 Immunohistochemistry (IHC) of anti-CDKN1B antibody    Immunohistochemistry of paraffin-embedded rat brain using CDKN1B Antibody at dilution of 1:200 (40x lens).
anti-CDKN1B antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CDKN1B antibody    Immunohistochemistry of paraffin-embedded mouse kidney using CDKN1B Antibody at dilution of 1:200 (40x lens).
anti-CDKN1B antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CDKN1B antibody    Immunohistochemistry of paraffin-embedded rat brain using CDKN1B Antibody at dilution of 1:100 (40x lens).
anti-CDKN1B antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-CDKN1B antibody    Immunofluosrescence analysis of Hela cells using CDKN1B antibody (MBS125745). Blue: DAPI for nuclear stainig.
anti-CDKN1B antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CDKN1B. It may not necessarily be applicable to this product.
 NCBI GI #    1168871
 NCBI GeneID    1027
 NCBI Accession #    P46527.1 [Other Products]
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 UniProt Primary Accession #    P46527 [Other Products]
 UniProt Secondary Accession #    Q16307; Q5U0H2; Q9BUS6 [Other Products]
 UniProt Related Accession #    P46527 [Other Products]
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 NCBI Official Full Name    Cyclin-dependent kinase inhibitor 1B
 NCBI Official Synonym Full Names    cyclin-dependent kinase inhibitor 1B (p27, Kip1)
 NCBI Official Symbol    CDKN1B [Similar Products]
 NCBI Official Synonym Symbols   
KIP1; MEN4; CDKN4; MEN1B; P27KIP1
[Similar Products]
 NCBI Protein Information    cyclin-dependent kinase inhibitor 1B
 UniProt Protein Name    Cyclin-dependent kinase inhibitor 1B
 UniProt Synonym Protein Names   
Cyclin-dependent kinase inhibitor p27; p27Kip1
 Protein Family    Cyclin-dependent kinase inhibitor
 UniProt Gene Name    CDKN1B [Similar Products]
 UniProt Synonym Gene Names    KIP1 [Similar Products]
 UniProt Entry Name    CDN1B_HUMAN
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 NCBI Summary for CDKN1B    This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
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 UniProt Comments for CDKN1B    p27Kip1: a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. May mediate TGF beta-induced g1 arrest. Its degradation is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

Protein type: Inhibitor; Protein kinase, regulatory subunit; Oncoprotein; Cell cycle regulation

Chromosomal Location of Human Ortholog: 12p13.1-p12

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol; endosome

Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; chaperone binding; protein complex binding; Hsp70 protein binding; caspase activator activity; protein phosphatase binding; transforming growth factor beta receptor, cytoplasmic mediator activity

Biological Process: response to peptide hormone stimulus; negative regulation of kinase activity; nerve growth factor receptor signaling pathway; positive regulation of microtubule polymerization; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; response to estradiol stimulus; negative regulation of cell proliferation; sensory perception of sound; positive regulation of cell proliferation; response to glucose stimulus; negative regulation of mitotic cell cycle; cell cycle arrest; inner ear development; potassium ion transport; response to drug; caspase activation; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cell motility; response to amino acid stimulus; response to cadmium ion; response to hypoxia; positive regulation of protein catabolic process; autophagic cell death; innate immune response; negative regulation of phosphorylation; negative regulation of cell growth; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; negative regulation of transcription, DNA-dependent; G1/S transition of mitotic cell cycle; negative regulation of apoptosis

Disease: Multiple Endocrine Neoplasia, Type Iv
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 Research Articles on CDKN1B    1. Low expression of KIP1 is associated with osteosarcoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDKN1B antibodyPathways associated with anti-CDKN1B antibody
 Reference Product  PubMed Publications
 CDK2 antibody  >1128 publications with CDKN1B and CDK2
 CCND1 antibody  >1099 publications with CDKN1B and CCND1
 CDK4 antibody  >670 publications with CDKN1B and CDK4
 SKP2 antibody  >422 publications with CDKN1B and SKP2
 CDK6 antibody  >244 publications with CDKN1B and CDK6
 CCND3 antibody  >127 publications with CDKN1B and CCND3
 COPS5 antibody  >60 publications with CDKN1B and COPS5
 CCNE1 antibody  >32 publications with CDKN1B and CCNE1
 CCNA2 antibody  >31 publications with CDKN1B and CCNA2
 UBC antibody  >6 publications with CDKN1B and UBC
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-CDKN1B antibodyOrgans/Tissues associated with anti-CDKN1B antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >581 publications with CDKN1B and Adenocarcinoma
 Breast Neoplasms Antibodies  >485 publications with CDKN1B and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >279 publications with CDKN1B and Prostatic Neoplasms
 Nervous System Diseases Antibodies  >277 publications with CDKN1B and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >272 publications with CDKN1B and Neoplasms, Experimental
 Intestinal Neoplasms Antibodies  >240 publications with CDKN1B and Intestinal Neoplasms
 Neoplasm Metastasis Antibodies  >217 publications with CDKN1B and Neoplasm Metastasis
 Hyperplasia Antibodies  >206 publications with CDKN1B and Hyperplasia
 Lung Neoplasms Antibodies  >203 publications with CDKN1B and Lung Neoplasms
 Liver Diseases Antibodies  >201 publications with CDKN1B and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >665 publications with CDKN1B and Blood
 Muscle Antibodies  >497 publications with CDKN1B and Muscle
 Vascular Antibodies  >433 publications with CDKN1B and Vascular
 Prostate Antibodies  >331 publications with CDKN1B and Prostate
 Lung Antibodies  >302 publications with CDKN1B and Lung
 Liver Antibodies  >292 publications with CDKN1B and Liver
 Brain Antibodies  >292 publications with CDKN1B and Brain
 Kidney Antibodies  >268 publications with CDKN1B and Kidney
 Bone Antibodies  >207 publications with CDKN1B and Bone
 Lymph Node Antibodies  >203 publications with CDKN1B and Lymph Node
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