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anti-CDKN1C antibody :: Rabbit CDKN1C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2522196
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDKN1C, Polyclonal Antibody

★Popular Item★
 Also Known As   

CDKN1C Polyclonal Antibody

 Product Synonym Names    BWS, WBS, p57, BWCR, KIP2, IMAGE
 Product Gene Name   

anti-CDKN1C antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    130650
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    0.6mg/mL (lot specific)
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 Immunogen    Synthetic peptide of human CDKN1C
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CDKN1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CDKN1C antibody

   This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
 Product Categories/Family for anti-CDKN1C antibody    Cell biology; Epigenetics
 Applications Tested/Suitable for anti-CDKN1C antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-CDKN1C antibody    IHC: 1:25-1:100
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 Immunohistochemistry (IHC) of anti-CDKN1C antibody    Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using CDKN1C Polyclonal Antibody at dilution 1:15
anti-CDKN1C antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CDKN1C antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CDKN1C Polyclonal Antibody at dilution 1:15
anti-CDKN1C antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CDKN1C. It may not necessarily be applicable to this product.
 NCBI GI #    169790903
 NCBI GeneID    1028
 NCBI Accession #    NP_001116103.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001122631.1 [Other Products]
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 UniProt Related Accession #    P49918 [Other Products]
 Molecular Weight    31,040 Da
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 NCBI Official Full Name    cyclin-dependent kinase inhibitor 1C isoform b
 NCBI Official Synonym Full Names    cyclin-dependent kinase inhibitor 1C (p57, Kip2)
 NCBI Official Symbol    CDKN1C [Similar Products]
 NCBI Official Synonym Symbols   
BWS; WBS; p57; BWCR; KIP2; p57Kip2
[Similar Products]
 NCBI Protein Information    cyclin-dependent kinase inhibitor 1C; cyclin-dependent kinase inhibitor p57
 UniProt Protein Name    Cyclin-dependent kinase inhibitor 1C
 UniProt Synonym Protein Names   
Cyclin-dependent kinase inhibitor p57; p57Kip2
 Protein Family    Cyclin-dependent kinase inhibitor
 UniProt Gene Name    CDKN1C [Similar Products]
 UniProt Synonym Gene Names    KIP2 [Similar Products]
 UniProt Entry Name    CDN1C_HUMAN
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 NCBI Summary for CDKN1C    This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
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 UniProt Comments for CDKN1C    p57Kip2: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life. Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver. Belongs to the CDI family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; Inhibitor; Cell cycle regulation; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cytoplasm; nucleus

Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding

Biological Process: negative regulation of kinase activity; camera-type eye development; adrenal gland development; multicellular organism growth; positive regulation of transcription, DNA-dependent; regulation of mitotic cell cycle; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; uterus development; neuron maturation; negative regulation of phosphorylation; myeloid cell differentiation; negative regulation of transcription, DNA-dependent; cell cycle arrest; kidney development; skeletal development; negative regulation of epithelial cell proliferation; aging

Disease: Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies; Beckwith-wiedemann Syndrome
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 Research Articles on CDKN1C    1. We report a novel CDKN1C mutation associated with features of IMAGe syndrome, but without adrenal insufficiency or metaphyseal dysplasia, and characterized by early-adulthood-onset diabetes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDKN1C antibodyPathways associated with anti-CDKN1C antibody
 Reference Product  PubMed Publications
 CCND1 antibody  >31 publications with CDKN1C and CCND1
 CDK2 antibody  >30 publications with CDKN1C and CDK2
 PCNA antibody  >28 publications with CDKN1C and PCNA
 CDK4 antibody  >21 publications with CDKN1C and CDK4
 CDK6 antibody  >8 publications with CDKN1C and CDK6
 SKP2 antibody  >7 publications with CDKN1C and SKP2
 CCNA2 antibody  >2 publications with CDKN1C and CCNA2
 CCNE2 antibody  >2 publications with CDKN1C and CCNE2
 MYOD1 antibody  >2 publications with CDKN1C and MYOD1
 CUL1 antibody  >1 publications with CDKN1C and CUL1
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 G1 To S Cell Cycle Control Pathway antibodies  G1 To S Cell Cycle Control Pathway Diagram
Diseases associated with anti-CDKN1C antibodyOrgans/Tissues associated with anti-CDKN1C antibody
 Disease Name  Pubmed Publications
 Beckwith-Wiedemann Syndrome Antibodies  >119 publications with CDKN1C and Beckwith-Wiedemann Syndrome
 Adenocarcinoma Antibodies  >35 publications with CDKN1C and Adenocarcinoma
 Kidney Diseases Antibodies  >26 publications with CDKN1C and Kidney Diseases
 Fetal Growth Retardation Antibodies  >22 publications with CDKN1C and Fetal Growth Retardation
 Hyperplasia Antibodies  >20 publications with CDKN1C and Hyperplasia
 Cell Transformation, Neoplastic Antibodies  >20 publications with CDKN1C and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >19 publications with CDKN1C and Liver Neoplasms
 Liver Diseases Antibodies  >18 publications with CDKN1C and Liver Diseases
 Disease Models, Animal Antibodies  >17 publications with CDKN1C and Disease Models, Animal
 Breast Neoplasms Antibodies  >16 publications with CDKN1C and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >64 publications with CDKN1C and Embryonic Tissue
 Placenta Antibodies  >59 publications with CDKN1C and Placenta
 Blood Antibodies  >49 publications with CDKN1C and Blood
 Muscle Antibodies  >49 publications with CDKN1C and Muscle
 Kidney Antibodies  >44 publications with CDKN1C and Kidney
 Eye Antibodies  >30 publications with CDKN1C and Eye
 Brain Antibodies  >29 publications with CDKN1C and Brain
 Liver Antibodies  >27 publications with CDKN1C and Liver
 Skin Antibodies  >23 publications with CDKN1C and Skin
 Heart Antibodies  >22 publications with CDKN1C and Heart
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