NP_000067.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
31,040 Da
NCBI Official Full Name
cyclin-dependent kinase inhibitor 1C isoform a
NCBI Official Synonym Full Names
cyclin dependent kinase inhibitor 1C
NCBI Official Synonym Symbols
BWS; WBS; p57; BWCR; KIP2; p57Kip2 [Similar Products]
NCBI Protein Information
cyclin-dependent kinase inhibitor 1C
UniProt Protein Name
Cyclin-dependent kinase inhibitor 1C
UniProt Synonym Protein Names
Cyclin-dependent kinase inhibitor p57; p57Kip2
UniProt Synonym Gene Names
NCBI Summary for CDKN1C
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
UniProt Comments for CDKN1C
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.MiscellaneousPaternally imprinted, therefore most expression comes from the maternal allele.
Research Articles on CDKN1C
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Diseases associated with anti-CDKN1C antibody
Organs/Tissues associated with anti-CDKN1C antibody
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