NP_000067.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
31,040 Da
NCBI Official Full Name
cyclin-dependent kinase inhibitor 1C isoform a
NCBI Official Synonym Full Names
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
NCBI Official Synonym Symbols
BWS; WBS; p57; BWCR; KIP2; p57Kip2 [Similar Products]
NCBI Protein Information
cyclin-dependent kinase inhibitor 1C
UniProt Protein Name
Cyclin-dependent kinase inhibitor 1C
UniProt Synonym Protein Names
Cyclin-dependent kinase inhibitor p57; p57Kip2
UniProt Synonym Gene Names
UniProt Entry Name
CDN1C_HUMAN
NCBI Summary for CDKN1C
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
UniProt Comments for CDKN1C
p57Kip2: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life. Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver. Belongs to the CDI family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Tumor suppressor; Inhibitor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cytoplasm; nucleus
Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding
Biological Process: negative regulation of kinase activity; camera-type eye development; adrenal gland development; positive regulation of transcription, DNA-dependent; multicellular organism growth; regulation of mitotic cell cycle; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; uterus development; neuron maturation; negative regulation of phosphorylation; myeloid cell differentiation; cell cycle arrest; kidney development; negative regulation of transcription, DNA-dependent; skeletal development; negative regulation of epithelial cell proliferation; aging
Disease: Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies; Beckwith-wiedemann Syndrome
Research Articles on CDKN1C
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Products associated with anti-CDKN1C antibody
Pathways associated with anti-CDKN1C antibody
Diseases associated with anti-CDKN1C antibody
Organs/Tissues associated with anti-CDKN1C antibody
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