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anti-CDKN2C antibody :: Rabbit CDKN2C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2520715
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDKN2C, Polyclonal Antibody

★Popular Item★
 Also Known As   

CDKN2C Polyclonal Antibody

 Product Synonym Names    p18; INK4C; p18-INK4C
 Product Gene Name   

anti-CDKN2C antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603369
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1.3mg/mL (lot specific)
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 Immunogen    Recombinant protein of human CDKN2C
 Calculated Molecular Weight: 18kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CDKN2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CDKN2C antibody

   The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported
 Product Categories/Family for anti-CDKN2C antibody    Cancer; Cell biology; Epigenetics
 Applications Tested/Suitable for anti-CDKN2C antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CDKN2C antibody    WB: 1:200-1:1000
IHC: 1:25-1:100
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 Western Blot (WB) of anti-CDKN2C antibody    Western Blot analysis of Raji cell using CDKN2C Polyclonal Antibody at dilution of 1:325
anti-CDKN2C antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CDKN2C antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer using CDKN2C Polyclonal Antibody at dilution of 1:25
anti-CDKN2C antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CDKN2C antibody    Immunohistochemistry of paraffin-embedded Human brain using CDKN2C Polyclonal Antibody at dilution of 1:25
anti-CDKN2C antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CDKN2C. It may not necessarily be applicable to this product.
 NCBI GI #    17981699
 NCBI GeneID    1031
 NCBI Accession #    NP_523240.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_078626.2 [Other Products]
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 UniProt Secondary Accession #    Q8TB83 [Other Products]
 UniProt Related Accession #    P42773 [Other Products]
 Molecular Weight    18,127 Da
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 NCBI Official Full Name    cyclin-dependent kinase 4 inhibitor C
 NCBI Official Synonym Full Names    cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
 NCBI Official Symbol    CDKN2C [Similar Products]
 NCBI Official Synonym Symbols   
p18; INK4C; p18-INK4C
[Similar Products]
 NCBI Protein Information    cyclin-dependent kinase 4 inhibitor C; CDK6 inhibitor p18; cyclin-dependent inhibitor; cyclin-dependent kinase 6 inhibitor p18; p18-INK6
 UniProt Protein Name    Cyclin-dependent kinase 4 inhibitor C
 UniProt Synonym Protein Names   
Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6
 Protein Family    Cyclin-dependent kinase 4 inhibitor
 UniProt Gene Name    CDKN2C [Similar Products]
 UniProt Synonym Gene Names    CDKN6 [Similar Products]
 UniProt Entry Name    CDN2C_HUMAN
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 NCBI Summary for CDKN2C    The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CDKN2C    CDKN2C: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Heterodimer of p18 with CDK6. Highest levels found in skeletal muscle. Also found in pancreas and heart. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

Protein type: Inhibitor; Cell cycle regulation; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding

Biological Process: negative regulation of cell proliferation; negative regulation of phosphorylation; oligodendrocyte differentiation; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; negative regulation of cell growth; cell cycle arrest; G1/S transition of mitotic cell cycle
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 Research Articles on CDKN2C    1. this studydemonstrated abundant levels of the critical negative cell-cycle regulators, p27(Kip1), its phosphorylated form, p-p27(S10), p18Ink4c, and GSK-3, in beta-cells of both adult human and mouse pancreatic islets, which contribute to maintenance of beta-cell quiescence.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDKN2C antibodyPathways associated with anti-CDKN2C antibody
 Reference Product  PubMed Publications
 CDKN1B antibody  >133 publications with CDKN2C and CDKN1B
 CDKN1A antibody  >113 publications with CDKN2C and CDKN1A
 CDK4 antibody  >101 publications with CDKN2C and CDK4
 CDK6 antibody  >77 publications with CDKN2C and CDK6
 CDKN2B antibody  >61 publications with CDKN2C and CDKN2B
 CCND1 antibody  >53 publications with CDKN2C and CCND1
 CDKN2D antibody  >41 publications with CDKN2C and CDKN2D
 E2F1 antibody  >7 publications with CDKN2C and E2F1
 SP1 antibody  >4 publications with CDKN2C and SP1
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cyclin D Associated Events In G1 Pathway antibodies  Cyclin D Associated Events In G1 Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 G1 Phase Pathway antibodies  G1 Phase Pathway Diagram
 G1 To S Cell Cycle Control Pathway antibodies  G1 To S Cell Cycle Control Pathway Diagram
Diseases associated with anti-CDKN2C antibodyOrgans/Tissues associated with anti-CDKN2C antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >35 publications with CDKN2C and Nervous System Diseases
 Brain Diseases Antibodies  >28 publications with CDKN2C and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >21 publications with CDKN2C and Cell Transformation, Neoplastic
 Cardiovascular Diseases Antibodies  >17 publications with CDKN2C and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >17 publications with CDKN2C and Adenocarcinoma
 Breast Neoplasms Antibodies  >16 publications with CDKN2C and Breast Neoplasms
 Disease Models, Animal Antibodies  >16 publications with CDKN2C and Disease Models, Animal
 Hyperplasia Antibodies  >13 publications with CDKN2C and Hyperplasia
 Neoplasms, Experimental Antibodies  >13 publications with CDKN2C and Neoplasms, Experimental
 Liver Diseases Antibodies  >11 publications with CDKN2C and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >41 publications with CDKN2C and Blood
 Brain Antibodies  >31 publications with CDKN2C and Brain
 Bone Antibodies  >25 publications with CDKN2C and Bone
 Bone Marrow Antibodies  >21 publications with CDKN2C and Bone Marrow
 Liver Antibodies  >17 publications with CDKN2C and Liver
 Pancreas Antibodies  >15 publications with CDKN2C and Pancreas
 Muscle Antibodies  >15 publications with CDKN2C and Muscle
 Kidney Antibodies  >11 publications with CDKN2C and Kidney
 Lung Antibodies  >11 publications with CDKN2C and Lung
 Testis Antibodies  >10 publications with CDKN2C and Testis
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