NP_001230526.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
136,527 Da
NCBI Official Full Name
cell adhesion molecule-related/down-regulated by oncogenes isoform 1
NCBI Official Synonym Full Names
cell adhesion associated, oncogene regulated
NCBI Protein Information
cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog; surface glycoprotein, Ig superfamily member
UniProt Protein Name
Cell adhesion molecule-related/down-regulated by oncogenes
UniProt Synonym Gene Names
UniProt Entry Name
CDON_HUMAN
NCBI Summary for CDON
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
UniProt Comments for CDON
CDON: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Defects in CDON are the cause of holoprosencephaly type 11 (HPE11). HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q24.2
Cellular Component: extracellular matrix; plasma membrane; integral to membrane
Molecular Function: protein binding
Biological Process: lens development in camera-type eye; smoothened signaling pathway; regulation of protein heterodimerization activity; satellite cell differentiation; cell fate specification; positive regulation of skeletal muscle development; anterior/posterior pattern formation; positive regulation of small GTPase mediated signal transduction; embryonic body morphogenesis; muscle cell differentiation; positive regulation of MAPKKK cascade; embryonic retina morphogenesis in camera-type eye; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of protein amino acid phosphorylation; cell adhesion; positive regulation of neuron differentiation; myoblast fusion
Disease: Holoprosencephaly 11
Research Articles on CDON
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Products associated with anti-CDON antibody
Pathways associated with anti-CDON antibody
Diseases associated with anti-CDON antibody
Organs/Tissues associated with anti-CDON antibody
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