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anti-CDSN antibody :: Rabbit anti-Human CDSN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7046195
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDSN, Polyclonal Antibody

★Popular Item★
 Also Known As   

CDSN Antibody

 Product Synonym Names    Corneodesmosin; S protein; CDSN
 Product Gene Name   

anti-CDSN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146520
 3D Structure    ModBase 3D Structure for Q15517
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Corneodesmosin protein
 Conjugate    Non-conjugated
 Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49616 / sc-49620 / sc-49621
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CDSN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CDSN antibody

   Important for the epidermal barrier integrity.
 Applications Tested/Suitable for anti-CDSN antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Immunohistochemistry (IHC) of anti-CDSN antibody    Immunohistochemistry of paraffin-embedded human lymphoid tissue using MBS7046195 at dilution of 1:100
anti-CDSN antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-CDSN antibody    Western Blot
Positive WB detected in:mouse liver tissue,mouse spleen tissue,mouse kidney tissue,MCF7 whole cell lysate
All lanes: CDSN antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52 kDa
Observed band size: 52,34 kDa

anti-CDSN antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CDSN antibody    Immunofluorescent analysis of HepG2 cells using MBS7046195 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-CDSN antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CDSN. It may not necessarily be applicable to this product.
 NCBI GI #    67782356
 NCBI GeneID    1041
 NCBI Accession #    NP_001255.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001264.4 [Other Products]
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 UniProt Primary Accession #    Q15517 [Other Products]
 UniProt Secondary Accession #    O43509; Q5SQ85; Q5STD2; Q7LA70; Q7LA71; Q86Z04; Q8IZU4; Q8IZU5; Q8IZU6; B0S7V2; B0UYZ7 [Other Products]
 UniProt Related Accession #    Q15517 [Other Products]
 Molecular Weight    51,522 Da
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 NCBI Official Full Name    corneodesmosin
 NCBI Official Synonym Full Names    corneodesmosin
 NCBI Official Symbol    CDSN [Similar Products]
 NCBI Official Synonym Symbols   
S; PSS; HTSS; PSS1; HTSS1; HYPT2
[Similar Products]
 NCBI Protein Information    corneodesmosin
 UniProt Protein Name    Corneodesmosin
 UniProt Synonym Protein Names   
S protein
 Protein Family    Corneodesmosin
 UniProt Gene Name    CDSN [Similar Products]
 UniProt Entry Name    CDSN_HUMAN
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 NCBI Summary for CDSN    This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. [provided by RefSeq, Dec 2014]
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 UniProt Comments for CDSN    CDSN: Important for the epidermal barrier integrity. Defects in CDSN are the cause of hypotrichosis type 2 (HYPT2). A condition characterized by the presence of less than the normal amount of hair. Affected individuals have normal hair in early childhood but experience progressive hair loss limited to the scalp beginning in the middle of the first decade and almost complete baldness by the third decade. Body hair, beard, eyebrows, axillary hair, teeth, and nails develop normally. Defects in CDSN are a cause of peeling skin syndrome (PSS); also known as peeling skin syndrome or deciduous skin or keratolysis exfoliativa congenita. A genodermatosis characterized by generalized, continuous shedding of the outer layers of the epidermis. Two main PSS subtypes have been suggested. Patients with non-inflammatory PSS (type A) manifest white scaling, with painless and easy removal of the skin, irritation when in contact with water, dust and sand, and no history of erythema, pruritis or atopy. Inflammatory PSS (type B) is associated with generalized erythema, pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly after. Several patients have been reported with high IgE levels. CDNS mutations are responsible for generalized, inflammatory peeling skin syndrome type B (PubMed:20691404).

Protein type: Secreted; Cell adhesion; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cornified envelope; desmosome; intercellular junction

Molecular Function: protein homodimerization activity

Biological Process: cell adhesion; cell-cell adhesion; epidermis development; skin morphogenesis

Disease: Hypotrichosis 2; Peeling Skin Syndrome 1
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 Research Articles on CDSN    1. Investigated potential direct protein-protein interactions between six late cornified envelope (LCE) proteins and two corneodesmosin sequence variants. Partial colocalization of LCE2 and CDSN was observed in normal and psoriasis skin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-CDSN antibodyOrgans/Tissues associated with anti-CDSN antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with CDSN and Inflammation
 HYPOTRICHOSIS 2 Antibodies  >3 publications with CDSN and HYPOTRICHOSIS 2
 Heart Diseases Antibodies  >2 publications with CDSN and Heart Diseases
 Necrosis Antibodies  >1 publications with CDSN and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >72 publications with CDSN and Skin
 Heart Antibodies  >2 publications with CDSN and Heart
 Mouth Antibodies  >1 publications with CDSN and Mouth
 Kidney Antibodies  >1 publications with CDSN and Kidney
 Thymus Antibodies  >1 publications with CDSN and Thymus
 Placenta Antibodies  >1 publications with CDSN and Placenta
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