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| Product Name
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CDX1, Polyclonal Antibody ★Popular Item★
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| Also Known As
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CDX1 Antibody
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| Product Synonym Names
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Homeobox protein CDX-1; Caudal-type homeobox protein 1; CDX1
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| OMIM
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U16360 Genomic DNA
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| 3D Structure
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ModBase 3D Structure for P47902
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| Clonality
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Polyclonal
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| Isotype
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IgG
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| Host
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Rabbit
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| Species Reactivity
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Human, Rat
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| Purity/Purification
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>95%, Protein G purified
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| Form/Format
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Liquid
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| Immunogen
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Recombinant Human Homeobox protein CDX-1 protein (206-245AA)
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| Conjugation
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Non-conjugated
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| Preservative
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0.03% Proclin 300
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| Constituents
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50% Glycerol, 0.01M PBS, pH 7.4
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| Preparation and Storage
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Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
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| ISO Certification
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Manufactured in an ISO 9001:2008 Certified Laboratory.
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| Other Notes
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Small volumes of anti-CDX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine.
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| Applications Tested/Suitable for anti-CDX1 antibody
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ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
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| Application Notes for anti-CDX1 antibody
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WB: 1:500-1:5000
IF: 1:50-1:200
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| Western Blot (WB) of anti-CDX1 antibody
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Western Blot
Positive WB detected in: Rat liver tissue
All lanes: CDX1 antibody at 4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 29,15 KDa
Observed band size: 29 KDa
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| Immunofluorescence (IF) of anti-CDX1 antibody
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Immunofluorescent analysis of Hela cells using MBS7051841 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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TOP
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| NCBI/Uniprot data below describe general gene information for CDX1. It may not necessarily be applicable to this product. |
| NCBI GI #
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121114296
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| NCBI GeneID
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1044
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| NCBI Accession #
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NP_001795.2
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_001804.2
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[Other Products]
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| UniProt Primary Accession #
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P47902
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[Other Products]
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| UniProt Secondary Accession #
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Q4VAU4; Q9NYK8
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[Other Products]
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| UniProt Related Accession #
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P47902
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[Other Products]
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| Molecular Weight
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14,661 Da
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TOP
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| NCBI Official Full Name
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homeobox protein CDX-1
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| NCBI Official Synonym Full Names
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caudal type homeobox 1
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| NCBI Official Symbol
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CDX1
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[Similar Products]
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| NCBI Protein Information
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homeobox protein CDX-1
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| UniProt Protein Name
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Homeobox protein CDX-1
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| UniProt Synonym Protein Names
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Caudal-type homeobox protein 1
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| Protein Family
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Homeobox protein
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| UniProt Gene Name
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CDX1
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[Similar Products]
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| NCBI Summary for CDX1
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This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]
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| UniProt Comments for CDX1
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CDX1: Could play a role in the terminal differentiation of the intestine. Belongs to the Caudal homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: nucleus
Molecular Function: protein binding
Biological Process: anterior/posterior axis specification; cell differentiation; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of somitogenesis
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TOP
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| Research Articles on CDX1
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1. Data indicate an association between highly fucosylated glycans and caudal type homeobox 1 (CDX1) and/or villin mRNA expression that both correlate with cell differentiation.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Products associated with anti-CDX1 antibody | Pathways associated with anti-CDX1 antibody |
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| Diseases associated with anti-CDX1 antibody | Organs/Tissues associated with anti-CDX1 antibody |
| Disease Name |
Pubmed Publications |
| Neoplasms Antibodies |
>82 publications with CDX1 and Neoplasms |
| Leukemia Antibodies |
>8 publications with CDX1 and Leukemia |
| Embryo Loss Antibodies |
>7 publications with CDX1 and Embryo Loss |
| Disease Models, Animal Antibodies |
>5 publications with CDX1 and Disease Models, Animal |
| Head and Neck Neoplasms Antibodies |
>5 publications with CDX1 and Head and Neck Neoplasms |
| Leukemia, Myeloid Antibodies |
>4 publications with CDX1 and Leukemia, Myeloid |
| Liver Neoplasms Antibodies |
>4 publications with CDX1 and Liver Neoplasms |
| Pancreatic Neoplasms Antibodies |
>4 publications with CDX1 and Pancreatic Neoplasms |
| Leukemia, Myeloid, Acute Antibodies |
>4 publications with CDX1 and Leukemia, Myeloid, Acute |
| Carcinoma, Squamous Cell Antibodies |
>3 publications with CDX1 and Carcinoma, Squamous Cell |
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Antibody 
