NP_001795.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,661 Da
NCBI Official Full Name
homeobox protein CDX-1
NCBI Official Synonym Full Names
caudal type homeobox 1
NCBI Protein Information
homeobox protein CDX-1
UniProt Protein Name
Homeobox protein CDX-1
UniProt Synonym Protein Names
Caudal-type homeobox protein 1
NCBI Summary for CDX1
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]
UniProt Comments for CDX1
CDX1: Could play a role in the terminal differentiation of the intestine. Belongs to the Caudal homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: nucleus
Molecular Function: protein binding
Biological Process: anterior/posterior axis specification; cell differentiation; organ morphogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of somitogenesis
Research Articles on CDX1
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Products associated with anti-CDX1 antibody
Pathways associated with anti-CDX1 antibody
Diseases associated with anti-CDX1 antibody
Disease Name |
Pubmed Publications |
Neoplasms Antibodies |
>82 publications with CDX1 and Neoplasms |
Leukemia Antibodies |
>8 publications with CDX1 and Leukemia |
Embryo Loss Antibodies |
>7 publications with CDX1 and Embryo Loss |
Disease Models, Animal Antibodies |
>5 publications with CDX1 and Disease Models, Animal |
Head and Neck Neoplasms Antibodies |
>5 publications with CDX1 and Head and Neck Neoplasms |
Leukemia, Myeloid Antibodies |
>4 publications with CDX1 and Leukemia, Myeloid |
Liver Neoplasms Antibodies |
>4 publications with CDX1 and Liver Neoplasms |
Pancreatic Neoplasms Antibodies |
>4 publications with CDX1 and Pancreatic Neoplasms |
Leukemia, Myeloid, Acute Antibodies |
>4 publications with CDX1 and Leukemia, Myeloid, Acute |
Carcinoma, Squamous Cell Antibodies |
>3 publications with CDX1 and Carcinoma, Squamous Cell |
Organs/Tissues associated with anti-CDX1 antibody
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