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anti-CD2 antibody :: Rabbit CEA Receptor, Long Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS612542 anti-CD2 antibody
Unit / Price
0.1 mg  /  $445 +1 FREE 8GB USB
0.2 mg  /  $575 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CEA Receptor, Long (CD2), Polyclonal Antibody

 Also Known As   

CEA Receptor, Long (CEARL, Nuclear Ribonucleoprotein, nRNP, hnRNP M4 isoform 1, Heterogeneous Nuclear Ribonucleoprotein A0)

 Product Synonym Names    Anti -CEA Receptor, Long (CEARL, Nuclear Ribonucleoprotein, nRNP, hnRNP M4 isoform 1, Heterogeneous Nuclear Ribonucleoprotein A0)
 Product Gene Name   

anti-CD2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (117297057..117311851). Location: 1p13.1
 OMIM    186990
 3D Structure    ModBase 3D Structure for P06729
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes human CEARL/hnRNP M4 isoform 1, Mr ~74-80kD. Additional proteins were also detected, Mr ~55 and 70kD.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide, before the addition of glycerol to 30%.
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 Immunogen    Synthetic peptide corresponding to aa161-182 [MATTGGMGMGPGGPGMITIPPS] of human carcinoembryonic antigen receptor "long" (CEARL), conjugated to KLH.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-CD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CD2 antibody    Antibodies; Abs to Nuclear Proteins
 Applications Tested/Suitable for anti-CD2 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

 Application Notes for anti-CD2 antibody    Suitable for use in Western Blot, Immunocytochemistry and FACS Analysis.
Dilution: Western Blot: 0.1-0.5ug/ml Detects CEARL in RIPA lysates from HeLa cells.
Immunocytochemistry: 1:1000 Reported to show positive immunostaining for CEARL in rat Kupffer cells.
FACS Analysis: Reported to detect CEARL in rat Kupffer cells by FACS analysis.
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NCBI/Uniprot data below describe general gene information for CD2. It may not necessarily be applicable to this product.
 NCBI GI #    119577065
 NCBI GeneID    914
 NCBI Accession #    EAW56661.1 [Other Products]
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 UniProt Primary Accession #    P06729 [Other Products]
 UniProt Secondary Accession #    Q96TE5 [Other Products]
 UniProt Related Accession #    P06729 [Other Products]
 Molecular Weight    39,448 Da [Similar Products]
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 NCBI Official Full Name    CD2 antigen (p50), sheep red blood cell receptor
 NCBI Official Synonym Full Names    CD2 molecule
 NCBI Official Symbol    CD2 [Similar Products]
 NCBI Official Synonym Symbols   
T11; SRBC; LFA-2
[Similar Products]
 NCBI Protein Information    T-cell surface antigen CD2; LFA-3 receptor; rosette receptor; erythrocyte receptor; lymphocyte-function antigen-2; T-cell surface antigen T11/Leu-5; CD2 antigen (p50), sheep red blood cell receptor
 UniProt Protein Name    T-cell surface antigen CD2
 UniProt Synonym Protein Names   
Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5
 Protein Family    T-cell surface antigen
 UniProt Gene Name    CD2 [Similar Products]
 UniProt Synonym Gene Names    SRBC [Similar Products]
 UniProt Entry Name    CD2_HUMAN
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 NCBI Summary for CD2    CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]
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 UniProt Comments for CD2    CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.

Protein type: Apoptosis; Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: internal side of plasma membrane; cell surface; anchored to plasma membrane; integral to plasma membrane; plasma membrane; extracellular region; intercellular junction; external side of plasma membrane

Molecular Function: protein binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: heterotypic cell-cell adhesion; cell-cell adhesion; cell surface receptor linked signal transduction; T cell activation; apoptosis; natural killer cell activation; regulation of T cell differentiation; positive regulation of tumor necrosis factor production; blood coagulation; lipid raft polarization; positive regulation of myeloid dendritic cell activation; leukocyte migration
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 Research Articles on CD2    1. Aberrant CD2 expression appears to further determine a shorter progression free survival
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD2 antibodyPathways associated with anti-CD2 antibody
 Reference Product  PubMed Publications
 CD58 antibody  >414 publications with CD2 and CD58
 PTPRC antibody  >342 publications with CD2 and PTPRC
 CD48 antibody  >145 publications with CD2 and CD48
 CD2AP antibody  >140 publications with CD2 and CD2AP
 LCK antibody  >79 publications with CD2 and LCK
 SH3KBP1 antibody  >19 publications with CD2 and SH3KBP1
 CD2BP2 antibody  >12 publications with CD2 and CD2BP2
 CD8A antibody  >3 publications with CD2 and CD8A
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-CD2 antibodyOrgans/Tissues associated with anti-CD2 antibody
 Disease Name  Pubmed Publications
 Lymphoma Antibodies  >827 publications with CD2 and Lymphoma
 Necrosis Antibodies  >307 publications with CD2 and Necrosis
 Lymphoma, B-Cell Antibodies  >235 publications with CD2 and Lymphoma, B-Cell
 Inflammation Antibodies  >225 publications with CD2 and Inflammation
 Kidney Diseases Antibodies  >142 publications with CD2 and Kidney Diseases
 Liver Diseases Antibodies  >123 publications with CD2 and Liver Diseases
 Anemia Antibodies  >98 publications with CD2 and Anemia
 Vascular Diseases Antibodies  >97 publications with CD2 and Vascular Diseases
 Fever Antibodies  >97 publications with CD2 and Fever
 Arthritis, Rheumatoid Antibodies  >82 publications with CD2 and Arthritis, Rheumatoid
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4601 publications with CD2 and Blood
 Bone Antibodies  >750 publications with CD2 and Bone
 Muscle Antibodies  >540 publications with CD2 and Muscle
 Kidney Antibodies  >472 publications with CD2 and Kidney
 Thymus Antibodies  >436 publications with CD2 and Thymus
 Lymph Node Antibodies  >380 publications with CD2 and Lymph Node
 Heart Antibodies  >303 publications with CD2 and Heart
 Spleen Antibodies  >271 publications with CD2 and Spleen
 Intestine Antibodies  >250 publications with CD2 and Intestine
 Lung Antibodies  >179 publications with CD2 and Lung
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