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anti-CEBPA antibody :: Rabbit CEBP Alpha Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175700
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CEBP Alpha (CEBPA), Polyclonal Antibody

 Also Known As   

Anti-CEBP Alpha antibody

 Product Synonym Names    CCAAT/enhancer-binding protein alpha(C/EBP alpha); CCAAT/enhancer binding protein(C/EBP), alpha; Apoptotic cysteine protease antibody; Apoptotic protease Mch 5 antibody; C/EBP alpha antibody; C/ebpalpha antibody; CAP4 antibody; Caspase 8 precursor antibody; CBF-A antibody; CCAAT Enhancer Binding Protein alpha antibody; CCAAT/enhancer binding protein(C/EBP), alpha antibody; CCAAT/enhancer-binding protein alpha antibody; CEBP antibody; CEBP A antibody; CEBP alpha antibody; Cebpa antibody; CEBPA_HUMAN antibody; FADD homologous ICE/CED 3 like protease antibody; FADD like ICE antibody; FLICE antibody; ICE like apoptotic protease 5 antibody; ICE8 antibody; MACH antibody; MCH5 antibody; MORT1 associated CED 3 homolog antibody
 Product Gene Name   

anti-CEBPA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    116897
 3D Structure    ModBase 3D Structure for P49715
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human CEBP Alpha (342-358aa FRQLPESSLVKAMGNCA), identical to the related mouse and rat sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CEBPA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CEBPA antibody

   Description: Rabbit IgG polyclonal antibody for CCAAT/enhancer-binding protein alpha(CEBPA) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.
Background: CEBPA, CCAAT/enhancer-binding protein alpha is a protein that in humans is encoded by the CEBPA gene. The CEBPA gene is intronless. Using human/hamster somatic cell hybrids containing restricted fragments of human chromosome 19, the CEBPA gene is mapped to chromosome 19q13.1, between the GPI and TGFB1 genes. The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis.
 Applications Tested/Suitable for anti-CEBPA antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

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 Testing Data of anti-CEBPA antibody    anti-CEBPA antibody Testing Data image
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 Testing Data #2 of anti-CEBPA antibody    anti-CEBPA antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for CEBPA. It may not necessarily be applicable to this product.
 NCBI GI #    166898082
 NCBI GeneID    1050
 NCBI Accession #    P49715.3 [Other Products]
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 UniProt Primary Accession #    P49715 [Other Products]
 UniProt Secondary Accession #    P78319; Q05CA4; A7LNP2 [Other Products]
 UniProt Related Accession #    P49715 [Other Products]
 Molecular Weight    37,561 Da
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 NCBI Official Full Name    CCAAT/enhancer-binding protein alpha
 NCBI Official Synonym Full Names    CCAAT/enhancer binding protein (C/EBP), alpha
 NCBI Official Symbol    CEBPA [Similar Products]
 NCBI Official Synonym Symbols   
CEBP; C/EBP-alpha
[Similar Products]
 NCBI Protein Information    CCAAT/enhancer-binding protein alpha
 UniProt Protein Name    CCAAT/enhancer-binding protein alpha
 Protein Family    CCAAT/enhancer-binding protein
 UniProt Gene Name    CEBPA [Similar Products]
 UniProt Synonym Gene Names    C/EBP alpha [Similar Products]
 UniProt Entry Name    CEBPA_HUMAN
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 NCBI Summary for CEBPA    This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
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 UniProt Comments for CEBPA    C/EBP-alpha: a bZIP transcription factor which can form homodimers or heterodimers with the related proteins CEBP-beta and CEBP-gamma. Binds to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: Rb-E2F complex; nuclear matrix; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; protein complex binding; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; fat cell differentiation; embryonic placenta development; macrophage differentiation; viral reproduction; cell maturation; response to glucocorticoid stimulus; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; negative regulation of cell proliferation; response to vitamin B2; acute-phase response; inner ear development; cholesterol metabolic process; mitochondrion organization and biogenesis; generation of precursor metabolites and energy; organ regeneration; granulocyte differentiation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; negative regulation of cyclin-dependent protein kinase activity; liver development; positive regulation of osteoblast differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; white fat cell differentiation; brown fat cell differentiation; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase III promoter; myeloid cell differentiation; positive regulation of transcription from RNA polymerase II promoter; urea cycle; lung development

Disease: Leukemia, Acute Myeloid
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 Research Articles on CEBPA    1. NFATc2 exhibited a higher relative affinity for binding site DS3 as compared with members of the C/EBP family (C/EBP alpha and beta).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CEBPA antibodyDiseases associated with anti-CEBPA antibody
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Disease Name  Pubmed Publications
 Leukemia, Myeloid, Acute Antibodies  >446 publications with CEBPA and Leukemia, Myeloid, Acute
 Liver Diseases Antibodies  >92 publications with CEBPA and Liver Diseases
 Insulin Resistance Antibodies  >87 publications with CEBPA and Insulin Resistance
 Inflammation Antibodies  >81 publications with CEBPA and Inflammation
 Necrosis Antibodies  >78 publications with CEBPA and Necrosis
 Fatty Liver Antibodies  >59 publications with CEBPA and Fatty Liver
 Disease Models, Animal Antibodies  >54 publications with CEBPA and Disease Models, Animal
 Liver Neoplasms Antibodies  >52 publications with CEBPA and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >46 publications with CEBPA and Cell Transformation, Neoplastic
 Carcinoma, Hepatocellular Antibodies  >45 publications with CEBPA and Carcinoma, Hepatocellular
Organs/Tissues associated with anti-CEBPA antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >439 publications with CEBPA and Blood
 Liver Antibodies  >352 publications with CEBPA and Liver
 Adipose Tissue Antibodies  >335 publications with CEBPA and Adipose Tissue
 Connective Tissue Antibodies  >223 publications with CEBPA and Connective Tissue
 Bone Antibodies  >200 publications with CEBPA and Bone
 Bone Marrow Antibodies  >161 publications with CEBPA and Bone Marrow
 Lung Antibodies  >72 publications with CEBPA and Lung
 Brain Antibodies  >52 publications with CEBPA and Brain
 Embryonic Tissue Antibodies  >49 publications with CEBPA and Embryonic Tissue
 Kidney Antibodies  >40 publications with CEBPA and Kidney
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