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anti-CERK antibody :: Rabbit anti-Human, Mouse CERK Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7047905
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CERK, Polyclonal Antibody

★Popular Item★
 Also Known As   

CERK Antibody

 Product Synonym Names    Ceramide kinase; hCERK; Acylsphingosine kinase; Lipid kinase 4; LK4; CERK; KIAA1646
 Product Gene Name   

anti-CERK antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AB079066 mRNA
 3D Structure    ModBase 3D Structure for Q8TCT0
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Ceramide kinase protein (212-478AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-79406 / sc-79409 / sc-98700
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CERK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CERK antibody

   Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.
 Applications Tested/Suitable for anti-CERK antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-CERK antibody    WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-CERK antibody    Western Blot
Positive WB detected in: Mouse heart tissue,Mouse lung tissue,Mouse kidney tissue
All lanes: CERK antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 60,38 kDa
Observed band size:60,48 kDa

anti-CERK antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CERK antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7047905 at dilution of 1:100
anti-CERK antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CERK antibody    Immunohistochemistry of paraffin-embedded human pancreatic cancer using MBS7047905 at dilution of 1:100
anti-CERK antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-CERK antibody    Immunofluorescent analysis of HepG2 cells using MBS7047905 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-CERK antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CERK. It may not necessarily be applicable to this product.
 NCBI GI #    20336726
 NCBI GeneID    64781
 NCBI Accession #    NP_073603.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_022766.5 [Other Products]
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 UniProt Primary Accession #    Q8TCT0 [Other Products]
 UniProt Secondary Accession #    Q6NX59; Q9BYB3; Q9UGE5; A0JNT4; A8K611 [Other Products]
 UniProt Related Accession #    Q8TCT0 [Other Products]
 Molecular Weight    37,781 Da
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 NCBI Official Full Name    ceramide kinase
 NCBI Official Synonym Full Names    ceramide kinase
 NCBI Official Symbol    CERK [Similar Products]
 NCBI Official Synonym Symbols   
LK4; hCERK; dA59H18.2; dA59H18.3
[Similar Products]
 NCBI Protein Information    ceramide kinase
 UniProt Protein Name    Ceramide kinase
 UniProt Synonym Protein Names   
Acylsphingosine kinase; Lipid kinase 4; LK4
 Protein Family    Ceramide kinase
 UniProt Gene Name    CERK [Similar Products]
 UniProt Synonym Gene Names    KIAA1646; hCERK; LK4 [Similar Products]
 UniProt Entry Name    CERK1_HUMAN
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 NCBI Summary for CERK    CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for CERK    CERK: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

Protein type: EC 2.7.1.138; Kinase, lipid; Lipid Metabolism - sphingolipid

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: integral to membrane; plasma membrane

Molecular Function: ceramide kinase activity; magnesium ion binding; protein binding

Biological Process: ceramide metabolic process; glycosphingolipid metabolic process
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 Research Articles on CERK    1. our findings identify a functional role for Cerk in breast cancer recurrence and suggest the clinical utility of agents targeted against this prosurvival pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CERK antibodyPathways associated with anti-CERK antibody
 Reference Product  PubMed Publications
 CERS5 antibody  >1 publications with CERK and CERS5
 CERS4 antibody  >1 publications with CERK and CERS4
 CERS6 antibody  >1 publications with CERK and CERS6
 SMPD1 antibody  >1 publications with CERK and SMPD1
 Products by Pathway  Pathway Diagram
 Glycosphingolipid Metabolism Pathway antibodies  Glycosphingolipid Metabolism Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
Diseases associated with anti-CERK antibodyOrgans/Tissues associated with anti-CERK antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >15 publications with CERK and Inflammation
 Breast Neoplasms Antibodies  >5 publications with CERK and Breast Neoplasms
 Necrosis Antibodies  >4 publications with CERK and Necrosis
 Disease Models, Animal Antibodies  >4 publications with CERK and Disease Models, Animal
 Kidney Diseases Antibodies  >3 publications with CERK and Kidney Diseases
 Liver Diseases Antibodies  >2 publications with CERK and Liver Diseases
 Insulin Resistance Antibodies  >2 publications with CERK and Insulin Resistance
 Glucose Intolerance Antibodies  >1 publications with CERK and Glucose Intolerance
 Hypertension Antibodies  >1 publications with CERK and Hypertension
 Carcinoma, Hepatocellular Antibodies  >1 publications with CERK and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with CERK and Blood
 Bone Antibodies  >5 publications with CERK and Bone
 Brain Antibodies  >5 publications with CERK and Brain
 Liver Antibodies  >4 publications with CERK and Liver
 Eye Antibodies  >4 publications with CERK and Eye
 Vascular Antibodies  >4 publications with CERK and Vascular
 Kidney Antibodies  >4 publications with CERK and Kidney
 Bone Marrow Antibodies  >4 publications with CERK and Bone Marrow
 Lung Antibodies  >3 publications with CERK and Lung
 Muscle Antibodies  >3 publications with CERK and Muscle
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