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anti-CFH antibody :: Sheep anti-Human CFH / Complement Factor H Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242293
Immunohistochemistry (IHC)
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CFH / Complement Factor H, Polyclonal Antibody

 Also Known As   

Sheep Polyclonal to Human CFH / Complement Factor H

 Product Synonym Names    Anti-CFH / Complement Factor H Antibody IHC-plus; CFH; Adrenomedullin binding protein; AHUS1; AMBP1; ARMS1; ARMD4; Beta-1-H-globulin; Factor H; Factor H-like 1; HF; HF2; H factor 1; H factor 2 (complement); HUS; HF1; Beta-1H; CFHL3; Complement factor H; H factor 1 (complement); Human CFH; Complement Factor H
 Product Gene Name   

anti-CFH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 610698
 3D Structure    ModBase 3D Structure for P08603
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 Clonality    Polyclonal
 Host    Sheep
 Species Reactivity    Human
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 Specificity    Recognizes human Factor H (B1H Globulin).
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, pH 7.2, 0.05% sodium azide
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Purified Human Factor H.
 Immunogen Type    Purified protein
 Immunogen    CFH / Complement Factor H antibody was raised against purified Human Factor H.
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-CFH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CFH antibody

   Factor H (CFH) is a protein with twenty short consensus repeat (SCR) domains. Factor H is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in Factor H have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
 Applications Tested/Suitable for anti-CFH antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-CFH antibody    ELISA, IHC-P (2.5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-CFH antibody    Anti-Factor H antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-CFH antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CFH. It may not necessarily be applicable to this product.
 NCBI GI #    62739186
 NCBI GeneID    3075
 NCBI Accession #    NP_000177.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000186.3 [Other Products]
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 UniProt Primary Accession #    P08603 [Other Products]
 UniProt Secondary Accession #    P78435; Q14570; Q2TAZ5; Q38G77; Q5TFM3; Q8N708; Q9NU86; A5PL14 [Other Products]
 UniProt Related Accession #    P08603 [Other Products]
 Molecular Weight    51,034 Da
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 NCBI Official Full Name    complement factor H isoform a
 NCBI Official Synonym Full Names    complement factor H
 NCBI Official Symbol    CFH [Similar Products]
 NCBI Official Synonym Symbols   
FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3
[Similar Products]
 NCBI Protein Information    complement factor H; beta-1H; factor H-like 1; beta-1-H-globulin; H factor 1 (complement); H factor 2 (complement); adrenomedullin binding protein; complement factor H, isoform b; age-related maculopathy susceptibility 1
 UniProt Protein Name    Complement factor H
 UniProt Synonym Protein Names   
H factor 1
 Protein Family    Complement factor
 UniProt Gene Name    CFH [Similar Products]
 UniProt Synonym Gene Names    HF; HF1; HF2 [Similar Products]
 UniProt Entry Name    CFAH_HUMAN
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 NCBI Summary for CFH    This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
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 UniProt Comments for CFH    CFH: Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway. Genetic variations in CFH are associated with basal laminar drusen (BLD); also known as drusen of Bruch membrane or cuticular drusen or grouped early adult-onset drusen. Drusen are extracellular deposits that accumulate below the retinal pigment epithelium on Bruch membrane. Basal laminar drusen refers to an early adult-onset drusen phenotype that shows a pattern of uniform small, slightly raised yellow subretinal nodules randomly scattered in the macula. In later stages, these drusen often become more numerous, with clustered groups of drusen scattered throughout the retina. In time these small basal laminar drusen may expand and ultimately lead to a serous pigment epithelial detachment of the macula that may result in vision loss. Defects in CFH are the cause of complement factor H deficiency (CFHD). A disorder that can manifest as several different phenotypes, including asymptomatic, recurrent bacterial infections, and renal failure. Laboratory features usually include decreased serum levels of factor H, complement component C3, and a decrease in other terminal complement components, indicating activation of the alternative complement pathway. It is associated with a number of renal diseases with variable clinical presentation and progression, including membranoproliferative glomerulonephritis and atypical hemolytic uremic syndrome. Defects in CFH are a cause of susceptibility to hemolytic uremic syndrome atypical type 1 (AHUS1). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Genetic variation in CFH is associated with age-related macular degeneration type 4 (ARMD4). ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin- containing structure known as Bruch membrane. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular space; extracellular region

Molecular Function: heparan sulfate proteoglycan binding; heparin binding; protein binding

Biological Process: complement activation, alternative pathway; regulation of complement activation; innate immune response; complement activation

Disease: Complement Factor H Deficiency; Basal Laminar Drusen; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1; Macular Degeneration, Age-related, 4
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 Research Articles on CFH    1. Index variants of AMD, rs1061170 (CFH) and rs10490924 (ARMS2), were associated with AMD at P=3.05x10(-8) and P=6.36x10(-6), respectively, in European Americans.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CFH antibodyDiseases associated with anti-CFH antibody
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Complement Cascade Pathway antibodies  Regulation Of Complement Cascade Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Disease Name  Pubmed Publications
 Macular Degeneration Antibodies  >498 publications with CFH and Macular Degeneration
 Macular Degeneration, Age-Related, 4 Antibodies  >189 publications with CFH and Macular Degeneration, Age-Related, 4
 Kidney Diseases Antibodies  >158 publications with CFH and Kidney Diseases
 Atypical Hemolytic Uremic Syndrome Antibodies  >127 publications with CFH and Atypical Hemolytic Uremic Syndrome
 Inflammation Antibodies  >84 publications with CFH and Inflammation
 Cardiovascular Diseases Antibodies  >67 publications with CFH and Cardiovascular Diseases
 Atrophy Antibodies  >53 publications with CFH and Atrophy
 Glomerulonephritis, Membranoproliferative Antibodies  >42 publications with CFH and Glomerulonephritis, Membranoproliferative
 Disease Models, Animal Antibodies  >31 publications with CFH and Disease Models, Animal
 Heart Diseases Antibodies  >27 publications with CFH and Heart Diseases
Organs/Tissues associated with anti-CFH antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >260 publications with CFH and Eye
 Kidney Antibodies  >121 publications with CFH and Kidney
 Vascular Antibodies  >87 publications with CFH and Vascular
 Ear Antibodies  >41 publications with CFH and Ear
 Brain Antibodies  >36 publications with CFH and Brain
 Liver Antibodies  >33 publications with CFH and Liver
 Heart Antibodies  >26 publications with CFH and Heart
 Skin Antibodies  >14 publications with CFH and Skin
 Nerve Antibodies  >13 publications with CFH and Nerve
 Lung Antibodies  >12 publications with CFH and Lung
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