Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow CFI rightarrow Polyclonal CFI  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • PLN Antibody
 • DNA-directed DNA-RNA polymerase mu (POLM) Recombinant Protein
 • Rabbit anti Bovine IgG (heavy and light chains) Secondary Antibody
 • Beta-defensin 4A (DEFB4A) Recombinant Protein
 • Lipocalin 2-NGAL (LCN2) Antibody
 • Fibronectin (FN) Antibody
 • Cathepsin-B (CTSB) Recombinant Protein
 • HTR2C - 5-HT2C Receptor Antibody
 • 20S proteasome (20SP) ELISA Kit
 • IgM, F(ab)'2 Antibody
 • PGF Antibody
 • ESCHERICHIA COLI Antibody
 • pituitary adenylate cyclase activating polypeptide (PACAP) ELISA Kit
 • CD3-Biotinylated Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CFI antibody :: Rabbit anti-Human,mouse CFI Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2541290
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CFI, Polyclonal Antibody

★Popular Item★
 Also Known As   

CFI Polyclonal Antibody

 Product Synonym Names    FI; IF; KAF; AHUS3; ARMD13; C3BINA; C3b-INA
 Product Gene Name   

anti-CFI antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 MBS2541290 Technical Datasheet    Technical Datasheet PDF
 OMIM    Y00318 mRNA
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human,mouse
Section Bar
 Purity/Purification    Affinity Purification
Section Bar
 Immunogen    Recombinant protein of human CFI
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3
 Calculated MW    66 kDa
 Observed MW    70 kDa
Section Bar
 Preparation and Storage    Store at -20C. Avoid freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CFI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-CFI antibody   

Western Blot (WB),Immunofluorescence (IF)

 Application Notes for anti-CFI antibody    WB: 1:500 - 1:2000
IF: 1:50 - 1:100
Section Bar
 Western Blot (WB) of anti-CFI antibody    Western blot analysis of extracts of various cells lines, using CFI Polyclonal Antibody at dilution of 1:1000
anti-CFI antibody Western Blot (WB) (WB) image
Section Bar
 Immunofluorescence (IF) of anti-CFI antibody    Immunofluorescence analysis of HeLa cell using CFI antibody. Blue: DAPI for nuclear staining.
anti-CFI antibody Immunofluorescence (IF) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CFI. It may not necessarily be applicable to this product.
 NCBI GI #    1061899980
 NCBI GeneID    3426
 NCBI GenBank Nucleotide #    NM_001331035.1 [Other Products]
Section Bar
 UniProt Secondary Accession #    O60442 [Other Products]
 UniProt Related Accession #    P05156 [Other Products]
Table BarTOPTable Bar
 NCBI Official Full Name    complement factor I isoform 3 preproprotein
 NCBI Official Synonym Full Names    complement factor I
 NCBI Official Symbol    CFI [Similar Products]
 NCBI Official Synonym Symbols   
FI; IF; KAF; AHUS3; ARMD13; C3BINA; C3b-INA
[Similar Products]
 NCBI Protein Information    complement factor I
 UniProt Protein Name    Complement factor I
 UniProt Synonym Protein Names   
C3B/C4B inactivator
 Protein Family    Complement factor
 UniProt Gene Name    CFI [Similar Products]
 UniProt Synonym Gene Names    IF [Similar Products]
 UniProt Entry Name    CFAI_HUMAN
Section Bar
 NCBI Summary for CFI    This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by RefSeq, Dec 2015]
Section Bar
 UniProt Comments for CFI    CFI: Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively. Defects in CFI are a cause of susceptibility to hemolytic uremic syndrome atypical type 3 (AHUS3). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Defects in CFI are the cause of complement factor I deficiency (CFI deficiency). CFI deficiency is an autosomal recessive condition associated with a propensity to pyogenic infections. Belongs to the peptidase S1 family.

Protein type: EC 3.4.21.45; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: extracellular region; extracellular space

Molecular Function: protein binding; serine-type endopeptidase activity

Biological Process: regulation of complement activation

Disease: Complement Factor I Deficiency; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 3; Macular Degeneration, Age-related, 13
Table BarTOPTable Bar
 Research Articles on CFI    1. Our results indicate that CFI polymorphisms are not significantly associated with VKH syndrome.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-CFI antibodyPathways associated with anti-CFI antibody
 Reference Product  PubMed Publications
 CFH antibody  >91 publications with CFI and CFH
 CFB antibody  >45 publications with CFI and CFB
 CD46 antibody  >39 publications with CFI and CD46
 CR1 antibody  >4 publications with CFI and CR1
 C4BPA antibody  >3 publications with CFI and C4BPA
 CFP antibody  >2 publications with CFI and CFP
 C4A antibody  >2 publications with CFI and C4A
 C4BPB antibody  >1 publications with CFI and C4BPB
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Complement Cascade Pathway antibodies  Regulation Of Complement Cascade Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
Diseases associated with anti-CFI antibodyOrgans/Tissues associated with anti-CFI antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >136 publications with CFI and Cardiovascular Diseases
 Heart Diseases Antibodies  >93 publications with CFI and Heart Diseases
 Kidney Diseases Antibodies  >72 publications with CFI and Kidney Diseases
 Anemia Antibodies  >58 publications with CFI and Anemia
 Atypical Hemolytic Uremic Syndrome Antibodies  >55 publications with CFI and Atypical Hemolytic Uremic Syndrome
 Inflammation Antibodies  >46 publications with CFI and Inflammation
 Macular Degeneration Antibodies  >41 publications with CFI and Macular Degeneration
 Lung Diseases Antibodies  >31 publications with CFI and Lung Diseases
 Hypertension Antibodies  >29 publications with CFI and Hypertension
 Breast Neoplasms Antibodies  >27 publications with CFI and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >261 publications with CFI and Blood
 Heart Antibodies  >84 publications with CFI and Heart
 Vascular Antibodies  >81 publications with CFI and Vascular
 Brain Antibodies  >65 publications with CFI and Brain
 Kidney Antibodies  >57 publications with CFI and Kidney
 Lung Antibodies  >43 publications with CFI and Lung
 Eye Antibodies  >39 publications with CFI and Eye
 Liver Antibodies  >34 publications with CFI and Liver
 Skin Antibodies  >27 publications with CFI and Skin
 Muscle Antibodies  >21 publications with CFI and Muscle
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions