AAA73561.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 168 Observed MW: 168
NCBI Official Full Name
CFTR, partial
NCBI Official Synonym Full Names
cystic fibrosis transmembrane conductance regulator
NCBI Official Synonym Symbols
NCBI Protein Information
cystic fibrosis transmembrane conductance regulator
UniProt Protein Name
Cystic fibrosis transmembrane conductance regulator
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase (EC:3.6.3.49); cAMP-dependent chloride channel
UniProt Synonym Gene Names
UniProt Entry Name
CFTR_RAT
NCBI Summary for CFTR
cAMP-activated chloride channel and ATP binding cassette (ABC) transporter involved in intestinal anion secretion [RGD, Feb 2006]
UniProt Comments for CFTR
CFTR: a member of the MRP subfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. Functions as a chloride channel and controls the regulation of other transport pathways. Mutations have been observed in patients with the autosomal recessive disorders cystic fibrosis (CF) and congenital bilateral aplasia of the vas deferens (CBAVD). Alternative splice
Protein type: EC 3.6.3.49; Membrane protein, multi-pass; Transporter, ABC family; Membrane protein, integral; Hydrolase; Channel, chloride; Transporter
Cellular Component: apical plasma membrane; basolateral plasma membrane; cell surface; cytoplasm; cytoplasmic vesicle membrane; cytosol; early endosome; early endosome membrane; microvillus; plasma membrane; protein complex; recycling endosome
Molecular Function: ATP binding; bicarbonate transmembrane transporter activity; channel-conductance-controlling ATPase activity; chloride channel activity; chloride channel inhibitor activity; chloride transmembrane transporter activity; enzyme binding; PDZ domain binding
Biological Process: bicarbonate transport; body fluid secretion; cellular response to hormone stimulus; chloride transport; cholesterol biosynthetic process; cholesterol transport; intracellular pH elevation; iodide transport; lung development; membrane hyperpolarization; positive regulation of exocytosis; positive regulation of vasodilation; response to cytokine stimulus; response to drug; response to estrogen stimulus; response to peptide hormone stimulus; sperm capacitation; transepithelial chloride transport; vasodilation; vesicle docking during exocytosis; water transport
Research Articles on CFTR
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Products associated with anti-CFTR antibody
Pathways associated with anti-CFTR antibody
Diseases associated with anti-CFTR antibody
Organs/Tissues associated with anti-CFTR antibody
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