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anti-Calca antibody :: Goat anti-Mouse CGRP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS220709 anti-Calca antibody
Unit / Price
0.1 mL  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CGRP (Calca), Polyclonal Antibody

 Also Known As   

GOAT ANTI RAT CALCITONIN GENE-RELATED PEPTIDE

 Product Gene Name   

anti-Calca antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P01256
 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Mouse
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 Form/Format    Purified
Purified Ig - liquid
 Concentration    IgG concentration 5.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Buffer Solution    Phosphate buffered saline
 Target Species    Rat
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-Calca antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Calca antibody

   Goat anti Rat Calcitonin Gene-Related Peptide antibody recognizes Calcitonin gene-related peptide, also known as CGRP, a neuropeptide that acts as a vasodilator and may play a role in migraine. Goat anti Rat Calcitonin Gene-Related Peptide antibody reacts with both the whole molecule (amino acids 1-37) and the C-terminal fragment (23-37).
 Applications Tested/Suitable for anti-Calca antibody   

Immunohistology Frozen, ELISA (EIA), Immunofluorescence (IF), Immunohistology Paraffin

 Application Notes for anti-Calca antibody    ELISA: Minimum Dilution: 1/500; Maximum Dilution: 1/2500
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NCBI/Uniprot data below describe general gene information for Calca. It may not necessarily be applicable to this product.
 NCBI GI #    76880482
 NCBI GeneID    24241
 NCBI Accession #    NP_001029127.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001033955.1 [Other Products]
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 UniProt Primary Accession #    P01256 [Other Products]
 UniProt Related Accession #    P01256; P01257 [Other Products]
 Molecular Weight    15,103 Da [Similar Products]
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 NCBI Official Full Name    calcitonin gene-related peptide 1 isoform Cgrp preproprotein
 NCBI Official Synonym Full Names    calcitonin-related polypeptide alpha
 NCBI Official Symbol    Calca [Similar Products]
 NCBI Official Synonym Symbols   
CAL6; CGRP; Cal1; Calc; RATCAL6; calcitonin
[Similar Products]
 NCBI Protein Information    calcitonin gene-related peptide 1; CGRP-I; alpha-type CGRP; calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha
 UniProt Protein Name    Calcitonin gene-related peptide 1
 UniProt Synonym Protein Names   
Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I
 Protein Family    Calcitonin
 UniProt Gene Name    Calca [Similar Products]
 UniProt Synonym Gene Names    Calc; CGRP-I [Similar Products]
 UniProt Entry Name    CALCA_RAT
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 NCBI Summary for Calca    an inhibitor of lactotroph function and a potent vasodilator [RGD, Feb 2006]
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 UniProt Comments for Calca    CALCA iso3: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; neuron projection; cell soma; cell; axon; cytoplasm; extracellular region; terminal button; intracellular; nucleus

Molecular Function: identical protein binding; neuropeptide hormone activity; calcitonin receptor binding; protein complex binding; receptor binding

Biological Process: negative regulation of osteoclast differentiation; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of cell adhesion; positive regulation of interleukin-1 alpha production; vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure; response to pain; positive regulation of vasodilation; protein amino acid phosphorylation; vasodilation; G-protein signaling, adenylate cyclase activating pathway; regulation of heart contraction; positive regulation of interleukin-8 production; monocyte chemotaxis; leukocyte adhesion; elevation of cytosolic calcium ion concentration; vasculature development; neuropeptide signaling pathway; receptor internalization; regulation of blood pressure; negative regulation of smooth muscle contraction; positive regulation of cAMP biosynthetic process; negative regulation of ossification; feeding behavior; negative regulation of blood pressure; positive regulation of adenylate cyclase activity; positive regulation of macrophage differentiation; detection of temperature stimulus involved in sensory perception of pain; inflammatory response; negative regulation of bone resorption; negative regulation of neurological process; neuromuscular junction development; aging; cytosolic calcium ion homeostasis; regulation of heart rate; adenylate cyclase activation; positive regulation of ossification; cellular calcium ion homeostasis; regulation of systemic arterial blood pressure by neurological process; G-protein coupled receptor internalization; response to heat; endothelial cell proliferation; activation of protein kinase activity; endothelial cell migration; negative regulation of transcription, DNA-dependent; embryo implantation
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 Research Articles on Calca    1. Immunohistochemistry showed that in the DRGs, TRPV1-, CGRP-, and SP-immunoreactive neurons were mostly small- and medium-sized and the proportion of TRPV1- and CGRP-labeled neurons
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Calca antibodyDiseases associated with anti-Calca antibody
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Calcitonin-like Ligand Receptors Pathway antibodies  Calcitonin-like Ligand Receptors Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >11 publications with Calca and Inflammation
 Hypertension Antibodies  >4 publications with Calca and Hypertension
 Neurogenic Inflammation Antibodies  >4 publications with Calca and Neurogenic Inflammation
 Migraine Disorders Antibodies  >4 publications with Calca and Migraine Disorders
 Headache Antibodies  >4 publications with Calca and Headache
 Pain Antibodies  >4 publications with Calca and Pain
 Kidney Diseases Antibodies  >3 publications with Calca and Kidney Diseases
 Edema Antibodies  >2 publications with Calca and Edema
 Necrosis Antibodies  >1 publications with Calca and Necrosis
 Wounds and Injuries Antibodies  >1 publications with Calca and Wounds and Injuries
Organs/Tissues associated with anti-Calca antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with Calca and Brain
 Dorsal Root Ganglion Antibodies  >1 publications with Calca and Dorsal Root Ganglion
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