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anti-CHAC1 antibody :: Rabbit anti-Human, mouse CHAC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7004223
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CHAC1, Polyclonal Antibody

★Popular Item★
 Also Known As   

CHAC1 Antibody

 Product Synonym Names    Glutathione-specific gamma-glutamylcyclotransferase 11 Publication; CHAC11; Blocks Notch protein1
 Product Gene Name   

anti-CHAC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    614587
 3D Structure    ModBase 3D Structure for Q9BUX1
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Purity/Purification    Affinity Purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Glutathione-specific gamma-glutamylcyclotransferase 1 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-133320 / sc-133321
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CHAC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CHAC1 antibody

   Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).
 Applications Tested/Suitable for anti-CHAC1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CHAC1 antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
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 Immunohistochemistry (IHC) of anti-CHAC1 antibody    Immunohistochemistry of paraffin-embedded human testis using MBS7004223 at dilution of 1:100
anti-CHAC1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-CHAC1 antibody    Immunofluorescence staining of Hela cells cells with MBS7004223 at 1:260,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4 degree C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
anti-CHAC1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CHAC1. It may not necessarily be applicable to this product.
 NCBI GI #    218563700
 NCBI GeneID    79094
 NCBI Accession #    NP_001136248.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001142776.1 [Other Products]
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 UniProt Primary Accession #    Q9BUX1 [Other Products]
 UniProt Secondary Accession #    Q0VIA0 [Other Products]
 UniProt Related Accession #    Q9BUX1 [Other Products]
 Molecular Weight    23,795 Da
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 NCBI Official Full Name    glutathione-specific gamma-glutamylcyclotransferase 1 isoform b
 NCBI Official Synonym Full Names    ChaC glutathione-specific gamma-glutamylcyclotransferase 1
 NCBI Official Symbol    CHAC1 [Similar Products]
 NCBI Protein Information    glutathione-specific gamma-glutamylcyclotransferase 1
 UniProt Protein Name    Glutathione-specific gamma-glutamylcyclotransferase 1
 UniProt Synonym Protein Names   
Blocks Notch protein
 Protein Family    Glutathione-specific gamma-glutamylcyclotransferase
 UniProt Gene Name    CHAC1 [Similar Products]
 UniProt Synonym Gene Names    Botch [Similar Products]
 UniProt Entry Name    CHAC1_HUMAN
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 UniProt Comments for CHAC1    CHAC1: Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Belongs to the chaC family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: cytosol; trans-Golgi network

Molecular Function: Notch binding; protein binding; transferase activity, transferring acyl groups

Biological Process: glutathione biosynthetic process; negative regulation of Notch signaling pathway; neurogenesis; Notch signaling pathway; response to unfolded protein; xenobiotic metabolic process
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 Research Articles on CHAC1    1. Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CHAC1 antibodyPathways associated with anti-CHAC1 antibody
 Reference Product  PubMed Publications
 ATF4 antibody  >9 publications with CHAC1 and ATF4
 ATF3 antibody  >6 publications with CHAC1 and ATF3
 VPS13A antibody  >3 publications with CHAC1 and VPS13A
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Glutathione Conjugation Pathway antibodies  Glutathione Conjugation Pathway Diagram
 Glutathione Synthesis And Recycling Pathway antibodies  Glutathione Synthesis And Recycling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Phase II Conjugation Pathway antibodies  Phase II Conjugation Pathway Diagram
Diseases associated with anti-CHAC1 antibodyOrgans/Tissues associated with anti-CHAC1 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with CHAC1 and Liver Diseases
 Nervous System Diseases Antibodies  >2 publications with CHAC1 and Nervous System Diseases
 Breast Neoplasms Antibodies  >2 publications with CHAC1 and Breast Neoplasms
 Inflammation Antibodies  >2 publications with CHAC1 and Inflammation
 Necrosis Antibodies  >2 publications with CHAC1 and Necrosis
 Brain Diseases Antibodies  >1 publications with CHAC1 and Brain Diseases
 Immune System Diseases Antibodies  >1 publications with CHAC1 and Immune System Diseases
 Disease Models, Animal Antibodies  >1 publications with CHAC1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with CHAC1 and Liver
 Kidney Antibodies  >1 publications with CHAC1 and Kidney
 Eye Antibodies  >1 publications with CHAC1 and Eye
 Muscle Antibodies  >1 publications with CHAC1 and Muscle
 Blood Antibodies  >1 publications with CHAC1 and Blood
 Brain Antibodies  >1 publications with CHAC1 and Brain
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