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anti-CHCHD3 antibody :: Goat CHCHD3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS244852
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CHCHD3, Polyclonal Antibody

 Also Known As   

Goat Polyclonal to Human CHCHD3

 Product Synonym Names    Anti-CHCHD3 Antibody (Internal) IHC-plus; CHCHD3; PPP1R22; MINOS3; Human CHCHD3
 Product Gene Name   

anti-CHCHD3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    613748
 3D Structure    ModBase 3D Structure for Q9NX63
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Gibbon, Human
Predicted Reactivity: Monkey, Bat, Bovine, Dog, Horse, Pig, Rabbit, Sheep (at least 90% immunogen sequence identity)
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 Specificity    Human CHCHD3.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide C-RSSEFYRVTTEQYQ from an internal region of human CHCHD3 (NP_060282.1). Percent identity by BLAST analysis: Human, Gibbon (100%); Monkey, Sheep, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Pig (93%).
 Immunogen Type    Synthetic peptide
 Immunogen    CHCHD3 antibody was raised against synthetic peptide C-RSSEFYRVTTEQYQ from an internal region of human CHCHD3 (NP_060282.1). Percent identity by BLAST analysis: Human, Gibbon (100%); Monkey, Sheep, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Pig (93%); Marmoset, Mouse, Rat, Hamster, Opossum (86%).
 Antigen Modification    Internal
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-CHCHD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CHCHD3 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CHCHD3 antibody    ELISA (1:32000), IHC-P (5 ug/ml), WB (0.3 - 1 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:32000. Western blot: Approx 26.2kDa band observed in Human Placenta lysates (calculated MW of 26kDa according to NP_060282.1). Recommended concentration: 0.3-1 ug/ml.
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 Immunohistochemistry (IHC) of anti-CHCHD3 antibody    Anti-CHCHD3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-CHCHD3 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-CHCHD3 antibody    CHCHD3 antibody (0.3 ug/ml) staining of Human Placenta lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-CHCHD3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CHCHD3. It may not necessarily be applicable to this product.
 NCBI GI #    8923390
 NCBI GeneID    54927
 NCBI Accession #    NP_060282.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_017812.2 [Other Products]
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 UniProt Primary Accession #    Q9NX63 [Other Products]
 UniProt Related Accession #    Q9NX63 [Other Products]
 Molecular Weight    26,152 Da
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 NCBI Official Full Name    MICOS complex subunit MIC19
 NCBI Official Synonym Full Names    coiled-coil-helix-coiled-coil-helix domain containing 3
 NCBI Official Symbol    CHCHD3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    MICOS complex subunit MIC19; protein phosphatase 1, regulatory subunit 22; mitochondrial inner membrane organizing system 3; coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial
 UniProt Protein Name    MICOS complex subunit MIC19
 UniProt Synonym Protein Names   
Coiled-coil-helix-coiled-coil-helix domain-containing protein 3
 UniProt Gene Name    CHCHD3 [Similar Products]
 UniProt Synonym Gene Names    MIC19; MINOS3 [Similar Products]
 UniProt Entry Name    MIC19_HUMAN
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 UniProt Comments for CHCHD3    CHCHD3: May be a scaffolding protein that stabilizes protein complexes involved in maintaining mitochondrial crista architecture and protein import.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: mitochondrion; mitochondrial inner membrane; cytoplasm; nucleus

Molecular Function: protein binding; protein complex scaffold; phosphatase binding

Biological Process: inner mitochondrial membrane organization and biogenesis; mitochondrial fusion; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter
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 Research Articles on CHCHD3    1. both the myristoylation and the CHCH domain are essential for the import and mitochondrial localization of ChChd3. Once imported, ChChd3 binds to Mia40 for further folding and assembly into macromolecular complexes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CHCHD3 antibodyDiseases associated with anti-CHCHD3 antibody
 Reference Product  PubMed Publications
 IMMT antibody  >6 publications with CHCHD3 and IMMT
 OPA1 antibody  >1 publications with CHCHD3 and OPA1
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with CHCHD3 and Brain Diseases
 Pancreatic Neoplasms Antibodies  >1 publications with CHCHD3 and Pancreatic Neoplasms
 Edema Antibodies  >1 publications with CHCHD3 and Edema
 Fatty Liver Antibodies  >1 publications with CHCHD3 and Fatty Liver
Organs/Tissues associated with anti-CHCHD3 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >7 publications with CHCHD3 and Muscle
 Brain Antibodies  >3 publications with CHCHD3 and Brain
 Liver Antibodies  >2 publications with CHCHD3 and Liver
 Vascular Antibodies  >2 publications with CHCHD3 and Vascular
 Blood Antibodies  >1 publications with CHCHD3 and Blood
 Mammary Gland Antibodies  >1 publications with CHCHD3 and Mammary Gland
 Heart Antibodies  >1 publications with CHCHD3 and Heart
 Bone Antibodies  >1 publications with CHCHD3 and Bone
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