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anti-CHD4 antibody :: Rabbit anti-Human CHD4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240754
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CHD4, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human CHD4

 Product Synonym Names    Anti-CHD4 Antibody IHC-plus; CHD4; ATP-dependent helicase CHD4; CHD-4; Mi-2b; Mi2-BETA; Human CHD4
 Product Gene Name   

anti-CHD4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603277
 3D Structure    ModBase 3D Structure for Q14839
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Protein G Purified
 Form/Format    PBS, 0.09% sodium azide.
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human CHD4.
 Immunogen Type    Synthetic peptide
 Immunogen    CHD4 antibody was raised against synthetic peptide from human CHD4.
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-CHD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CHD4 antibody

   The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. Patients with dermatomyositis develop antibodies against the nuclear antigen chromodomain helicase DNA binding protein 4. The protein exists in a complex containing histone deacetylase and nucleosome remodeling activities, suggesting a role for chromatin reorganization in cancer metastasis.
 Applications Tested/Suitable for anti-CHD4 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-CHD4 antibody    ELISA (1:000 - 1:1000), IHC-P (20 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-CHD4 antibody    Anti-CHD4 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
anti-CHD4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CHD4. It may not necessarily be applicable to this product.
 NCBI GI #    51599156
 NCBI GeneID    1108
 NCBI Accession #    NP_001264.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001273.3 [Other Products]
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 UniProt Primary Accession #    Q14839 [Other Products]
 UniProt Secondary Accession #    Q8IXZ5 [Other Products]
 UniProt Related Accession #    Q14839 [Other Products]
 Molecular Weight    220,848 Da
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 NCBI Official Full Name    chromodomain-helicase-DNA-binding protein 4 isoform 1
 NCBI Official Synonym Full Names    chromodomain helicase DNA binding protein 4
 NCBI Official Symbol    CHD4 [Similar Products]
 NCBI Official Synonym Symbols   
CHD-4; Mi-2b; Mi2-BETA
[Similar Products]
 NCBI Protein Information    chromodomain-helicase-DNA-binding protein 4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein
 UniProt Protein Name    Chromodomain-helicase-DNA-binding protein 4
 UniProt Synonym Protein Names   
ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Mi2-beta
 Protein Family    Chromodomain-helicase-DNA-binding protein
 UniProt Gene Name    CHD4 [Similar Products]
 UniProt Synonym Gene Names    CHD-4 [Similar Products]
 UniProt Entry Name    CHD4_HUMAN
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 NCBI Summary for CHD4    The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
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 UniProt Comments for CHD4    CHD-4: is an ATP-dependent helicase and a central component of the HDAC-containing nucleosome remodeling and histone deacetylase (NuRD) transcriptional complex. Interacts with MTA1/2, HDAC1, and RbAp46 in the NuRD complex. CHD-4 belongs to the SNF2/RAD54 helicase family of proteins. The NuRD complex, whose subunit composition varies by cell type and in response to physiologic signals, plays central roles in many processes including oncogenesis and metastasis, B cell differentiation, invasive growth of breast cancer, and maintaining the balance between the undifferentiated state and the process of differentiation in embryonic stem cells.

Protein type: DNA-binding; Helicase; EC 3.6.4.12

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: nucleoplasm; centrosome; protein complex; membrane; nuclear chromatin; cytoplasm; NuRD complex; nucleus

Molecular Function: ATP-dependent DNA helicase activity; protein binding; nucleosomal DNA binding; DNA binding; zinc ion binding; microtubule binding; ATP binding

Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; ATP-dependent chromatin remodeling; spindle assembly; DNA duplex unwinding
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 Research Articles on CHD4    1. Endogenous Mta1/2 forms a complex with chromodomain helicase (Chd)4, histone deacetylases (Hdac)1/2, RbAp46/48, and Mbd3 in rat cerebellum
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CHD4 antibodyPathways associated with anti-CHD4 antibody
 Reference Product  PubMed Publications
 HDAC1 antibody  >14 publications with CHD4 and HDAC1
 CHD3 antibody  >13 publications with CHD4 and CHD3
 MTA2 antibody  >9 publications with CHD4 and MTA2
 HDAC2 antibody  >9 publications with CHD4 and HDAC2
 MTA1 antibody  >8 publications with CHD4 and MTA1
 MBD3 antibody  >8 publications with CHD4 and MBD3
 RBBP4 antibody  >4 publications with CHD4 and RBBP4
 RBBP7 antibody  >3 publications with CHD4 and RBBP7
 SIN3A antibody  >2 publications with CHD4 and SIN3A
 MCRS1 antibody  >1 publications with CHD4 and MCRS1
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 HDACs Deacetylate Histones Pathway antibodies  HDACs Deacetylate Histones Pathway Diagram
 RNA Polymerase I Promoter Clearance Pathway antibodies  RNA Polymerase I Promoter Clearance Pathway Diagram
 RNA Polymerase I Transcription Pathway antibodies  RNA Polymerase I Transcription Pathway Diagram
 RNA Polymerase I Transcription Initiation Pathway antibodies  RNA Polymerase I Transcription Initiation Pathway Diagram
 RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies  RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram
 Viral Carcinogenesis Pathway antibodies  Viral Carcinogenesis Pathway Diagram
Diseases associated with anti-CHD4 antibodyOrgans/Tissues associated with anti-CHD4 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >19 publications with CHD4 and Nervous System Diseases
 Carcinoma Antibodies  >6 publications with CHD4 and Carcinoma
 Immune System Diseases Antibodies  >2 publications with CHD4 and Immune System Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with CHD4 and Cell Transformation, Neoplastic
 Carcinoma, Hepatocellular Antibodies  >2 publications with CHD4 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >2 publications with CHD4 and Liver Diseases
 Inflammation Antibodies  >2 publications with CHD4 and Inflammation
 Liver Neoplasms Antibodies  >2 publications with CHD4 and Liver Neoplasms
 Endometrial Neoplasms Antibodies  >2 publications with CHD4 and Endometrial Neoplasms
 Necrosis Antibodies  >1 publications with CHD4 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with CHD4 and Blood
 Nerve Antibodies  >7 publications with CHD4 and Nerve
 Muscle Antibodies  >6 publications with CHD4 and Muscle
 Brain Antibodies  >6 publications with CHD4 and Brain
 Lung Antibodies  >5 publications with CHD4 and Lung
 Liver Antibodies  >4 publications with CHD4 and Liver
 Thyroid Antibodies  >3 publications with CHD4 and Thyroid
 Embryonic Tissue Antibodies  >3 publications with CHD4 and Embryonic Tissue
 Bone Antibodies  >3 publications with CHD4 and Bone
 Prostate Antibodies  >2 publications with CHD4 and Prostate
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