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anti-CHD7 antibody :: Goat CHD7 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420342 anti-CHD7 antibody
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CHD7, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-CHD7 Antibody

 Product Synonym Names    chromodomain helicase DNA binding protein 7; FLJ20357; FLJ20361; IS3; KIAA1416; Scoliosis, idiopathic 3; chromodomain helicase DNA binding protein 7 antibody; FLJ20357 antibody; FLJ20361 antibody; IS3 antibody; KIAA1416 antibody; Scoliosis; idiopathic 3 antibody
 Product Gene Name   

anti-CHD7 antibody

[Similar Products]
 Antibody/Peptide Pairs    CHD7 peptide (MBS426334) is used for blocking the activity of CHD7 antibody (MBS420342)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KDEIDEFANS PSE
 OMIM    214800
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-KDEIDEFANSPSE, from the internal region of the protein sequence according to NP_060250.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CHD7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CHD7 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-CHD7 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Preliminary experiments gave bands at approx 250kDa and 48kDa in Rat Spinal Cord lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 336kDa according to Human NP_060250.2 and 175kDa according to predicted Rat NP_001101376.1. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
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NCBI/Uniprot data below describe general gene information for CHD7. It may not necessarily be applicable to this product.
 NCBI GI #    54112403
 NCBI GeneID    55636
 NCBI Accession #    NP_060250.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_017780.3 [Other Products]
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 UniProt Secondary Accession #    Q05DI5; Q2TAN4; Q66K35; Q7Z6C0; Q7Z7Q2; Q9NXA0; Q9NXA3; D0VBA5; E9PNZ2 [Other Products]
 UniProt Related Accession #    Q9P2D1 [Other Products]
 Molecular Weight    101,085 Da
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 NCBI Official Full Name    chromodomain-helicase-DNA-binding protein 7 isoform 1
 NCBI Official Synonym Full Names    chromodomain helicase DNA binding protein 7
 NCBI Official Symbol    CHD7 [Similar Products]
 NCBI Official Synonym Symbols   
CRG; HH5; IS3; KAL5
[Similar Products]
 NCBI Protein Information    chromodomain-helicase-DNA-binding protein 7
 UniProt Protein Name    Chromodomain-helicase-DNA-binding protein 7
 UniProt Synonym Protein Names   
ATP-dependent helicase CHD7
 Protein Family    Chromodomain-helicase-DNA-binding protein
 UniProt Gene Name    CHD7 [Similar Products]
 UniProt Synonym Gene Names    KIAA1416; CHD-7 [Similar Products]
 UniProt Entry Name    CHD7_HUMAN
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 NCBI Summary for CHD7    This gene encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
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 UniProt Comments for CHD7    CHD-7: Probable transcription regulator. May interact with CTCF. Interacts with CHD8. Widely expressed in fetal and adult tissues. Belongs to the SNF2/RAD54 helicase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Helicase; DNA-binding; EC 3.6.4.12; Nucleolus

Chromosomal Location of Human Ortholog: 8q12.2

Cellular Component: nucleolus; nucleus

Molecular Function: ATP binding; chromatin binding; helicase activity; protein binding

Biological Process: adult heart development; adult walking behavior; artery morphogenesis; blood circulation; central nervous system development; chromatin modification; cognition; cranial nerve development; embryonic hindlimb morphogenesis; female genitalia development; genitalia development; heart morphogenesis; in utero embryonic development; inner ear morphogenesis; limb development; nose development; olfactory behavior; olfactory bulb development; olfactory nerve development; palate development; positive regulation of multicellular organism growth; regulation of growth hormone secretion; regulation of neurogenesis; regulation of transcription, DNA-dependent; retina development in camera-type eye; rRNA processing; semicircular canal morphogenesis; sensory perception of sound; skeletal development; T cell differentiation; transcription, DNA-dependent

Disease: Charge Syndrome; Hypogonadotropic Hypogonadism 5 With Or Without Anosmia; Tracheoesophageal Fistula With Or Without Esophageal Atresia
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 Research Articles on CHD7    1. Here, we review recent work aimed at understanding the mechanism of CHD7 function in normal and pathological states, highlighting results from biochemical and in vivo studies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CHD7 antibodyPathways associated with anti-CHD7 antibody
 Reference Product  PubMed Publications
 FGF8 antibody  >32 publications with CHD7 and FGF8
 PROKR2 antibody  >30 publications with CHD7 and PROKR2
 SMARCA4 antibody  >3 publications with CHD7 and SMARCA4
 SETDB1 antibody  >1 publications with CHD7 and SETDB1
 NLK antibody  >1 publications with CHD7 and NLK
 Products by Pathway  Pathway Diagram
 Noncanonical Wnt Signaling Pathway antibodies  Noncanonical Wnt Signaling Pathway Diagram
Diseases associated with anti-CHD7 antibodyOrgans/Tissues associated with anti-CHD7 antibody
 Disease Name  Pubmed Publications
 CHARGE Syndrome Antibodies  >208 publications with CHD7 and CHARGE Syndrome
 Kallmann Syndrome Antibodies  >41 publications with CHD7 and Kallmann Syndrome
 Idiopathic Hypogonadotropic Hypogonadism Antibodies  >10 publications with CHD7 and Idiopathic Hypogonadotropic Hypogonadism
 Death Antibodies  >8 publications with CHD7 and Death
 Immune System Diseases Antibodies  >4 publications with CHD7 and Immune System Diseases
 Fetal Growth Retardation Antibodies  >3 publications with CHD7 and Fetal Growth Retardation
 Brain Diseases Antibodies  >2 publications with CHD7 and Brain Diseases
 Prenatal Exposure Delayed Effects Antibodies  >2 publications with CHD7 and Prenatal Exposure Delayed Effects
 Colonic Neoplasms Antibodies  >2 publications with CHD7 and Colonic Neoplasms
 Prenatal Injuries Antibodies  >2 publications with CHD7 and Prenatal Injuries
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >109 publications with CHD7 and Heart
 Nerve Antibodies  >33 publications with CHD7 and Nerve
 Brain Antibodies  >32 publications with CHD7 and Brain
 Eye Antibodies  >31 publications with CHD7 and Eye
 Bone Antibodies  >24 publications with CHD7 and Bone
 Blood Antibodies  >17 publications with CHD7 and Blood
 Embryonic Tissue Antibodies  >16 publications with CHD7 and Embryonic Tissue
 Muscle Antibodies  >7 publications with CHD7 and Muscle
 Mouth Antibodies  >5 publications with CHD7 and Mouth
 Thymus Antibodies  >4 publications with CHD7 and Thymus
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