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anti-CHML antibody :: Rabbit anti-Human, Mouse CHML Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9605823
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CHML, Polyclonal Antibody

★Popular Item★
 Also Known As   

CHML Antibody

 Product Synonym Names    CHM like; Chml; Choroideraemia like protein; Choroideraemia-like protein; Choroideremia like (Rab escort protein 2); Choroideremia like; Choroideremia like protein; Rab escort protein 2; Rab proteins geranylgeranyltransferase component A 2; RAE2_HUMAN; REP 2; REP-2; REP2
 Product Gene Name   

anti-CHML antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P26374
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    CHML antibody detects endogenous levels of total CHML
 Purity/Purification    The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide
 Subcellular Location    Cytosol
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-CHML antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CHML antibody

   Function: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.
Subunit Structure: Monomer. Heterotrimer composed of RABGGTA, RABGGTB and CHML; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHML (component A) mediates Rab protein binding. Interacts with RAB1A, RAB7A and RAB27A, but has much lower affinity for RAB1A, RAB7A and RAB27A than CHM.
Similarity: Belongs to the Rab GDI family.
 Applications Tested/Suitable for anti-CHML antibody   

Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)

 Application Notes for anti-CHML antibody    WB: 1:500-1:1000
IHC: 1:50-1:200
IF/ICC: 1:100-1:500
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 Immunohistochemistry (IHC) of anti-CHML antibody    MBS9605823 at 1/100 staining Human prostate tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
anti-CHML antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-CHML antibody    Western blot analysis of extracts from 293, using CHML Antibody. Lane 1 was treated with the blocking peptide.
anti-CHML antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-CHML antibody    MBS9605823 staining COLO205 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
anti-CHML antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-CHML antibody    Western blot analysis of extracts from COLO cells, using CHML antibody.The lane on the left is treated with the antigen-specific peptide.
anti-CHML antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CHML. It may not necessarily be applicable to this product.
 NCBI GI #    53832014
 NCBI GeneID    1122
 NCBI Accession #    NP_001812.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001821.3 [Other Products]
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 UniProt Primary Accession #    P26374 [Other Products]
 UniProt Secondary Accession #    Q17RE0; Q9H1Y4; B2RAB9 [Other Products]
 UniProt Related Accession #    P26374 [Other Products]
 Molecular Weight    Observed: 85 kD
Predicted: 75 kDa
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 NCBI Official Full Name    rab proteins geranylgeranyltransferase component A 2
 NCBI Official Synonym Full Names    CHM like, Rab escort protein 2
 NCBI Official Symbol    CHML [Similar Products]
 NCBI Official Synonym Symbols   
REP2
[Similar Products]
 NCBI Protein Information    rab proteins geranylgeranyltransferase component A 2
 UniProt Protein Name    Rab proteins geranylgeranyltransferase component A 2
 UniProt Synonym Protein Names   
Choroideremia-like protein; Rab escort protein 2; REP-2
 Protein Family    Rab proteins geranylgeranyltransferase component
 UniProt Gene Name    CHML [Similar Products]
 UniProt Synonym Gene Names    REP2; REP-2 [Similar Products]
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 NCBI Summary for CHML    The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CHML    Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.
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 Research Articles on CHML    1. Polymorphisms in the OPN3 and CHML genes are associated with asthma and atopic asthma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CHML antibodyDiseases associated with anti-CHML antibody
 Reference Product  PubMed Publications
 RAB5A antibody  >1 publications with CHML and RAB5A
 RAB3A antibody  >1 publications with CHML and RAB3A
 RAB1A antibody  >1 publications with CHML and RAB1A
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with CHML and Neoplasms
 Drug Toxicity Antibodies  >2 publications with CHML and Drug Toxicity
 Immune System Diseases Antibodies  >2 publications with CHML and Immune System Diseases
 Skin Neoplasms Antibodies  >1 publications with CHML and Skin Neoplasms
 Liver Neoplasms Antibodies  >1 publications with CHML and Liver Neoplasms
 Fatty Liver Antibodies  >1 publications with CHML and Fatty Liver
 Carcinoma, Hepatocellular Antibodies  >1 publications with CHML and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with CHML and Liver Diseases
 Nervous System Diseases Antibodies  >1 publications with CHML and Nervous System Diseases
 Hematologic Diseases Antibodies  >1 publications with CHML and Hematologic Diseases
Organs/Tissues associated with anti-CHML antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >4 publications with CHML and Skin
 Eye Antibodies  >4 publications with CHML and Eye
 Lung Antibodies  >3 publications with CHML and Lung
 Liver Antibodies  >2 publications with CHML and Liver
 Brain Antibodies  >2 publications with CHML and Brain
 Testis Antibodies  >1 publications with CHML and Testis
 Kidney Antibodies  >1 publications with CHML and Kidney
 Bladder Antibodies  >1 publications with CHML and Bladder
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