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anti-CYP46A1 antibody :: Goat CHOLESTEROL 24-HYDROXYLASE Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS222345 anti-CYP46A1 antibody
Unit / Price
0.1 mL  /  $425 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CHOLESTEROL 24-HYDROXYLASE (CYP46A1), Polyclonal Antibody

 Also Known As   

GOAT ANTI CHOLESTEROL 24-HYDROXYLASE (C-TERMINAL)

 Product Gene Name   

anti-CYP46A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604087
 3D Structure    ModBase 3D Structure for Q9Y6A2
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
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 Specificity    This item recognises cholesterol 24-hydroxylase (CYP46A1), a 58 kDa member of the Cytochrome P450 family, expressed in the brain. CYP46A1 converts cholesterol into the biologically active oxysterol and 24(S)-hydroxycholesterol, in the first step of the enzymatic degradation of cholesterol in the brain. CYP46A1 is also thought to play a role in the metabolism of neurosteroids and drugs that can cross the blood-brain barrier and are targeted to the central nervous system.

P450 enzymes are divided into two groups: steroidogenic and xenobiotic. The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism. Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members: CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1.
 Form/Format    Serum
Serum - liquid
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
 Immunogen    Synthetic peptide corresponding to amino acid sequence 254-270 of human cholesterol 24-hydroxylase protein.
 Antiserum Preparation    Antisera to cholesterol 24-hydroxylase (CT) were raised by repeated immunisations of goats with highly purified antigen.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CYP46A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CYP46A1 antibody

   MBS222345 recognises cholesterol 24-hydroxylase (CYP46A1), a 58 kDa member of the Cytochrome P450 family, expressed in the brain. CYP46A1 converts cholesterol into the biologically active oxysterol and 24(S)-hydroxycholesterol, in the first step of the enzymatic degradation of cholesterol in the brain. CYP46A1 is also thought to play a role in the metabolism of neurosteroids and drugs that can cross the blood-brain barrier and are targeted to the central nervous system. P450 enzymes are divided into two groups: steroidogenic and xenobiotic. The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism. Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members: CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1.
 Applications Tested/Suitable for anti-CYP46A1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-CYP46A1 antibody    Western Blot: This item detects a band of approximately 58kDa in human Alzheimer diseased brain lysates.
ELISA: Maximum Dilution: 1/15000
Western Blotting: Maximum Dilution: 1/3000
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NCBI/Uniprot data below describe general gene information for CYP46A1. It may not necessarily be applicable to this product.
 NCBI GI #    5729796
 NCBI GeneID    10858
 NCBI Accession #    NP_006659.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006668.1 [Other Products]
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 UniProt Primary Accession #    Q9Y6A2 [Other Products]
 UniProt Secondary Accession #    Q8N2B0; B4DHP8; E7EQG9 [Other Products]
 UniProt Related Accession #    Q9Y6A2 [Other Products]
 Molecular Weight    38,315 Da [Similar Products]
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 NCBI Official Full Name    cholesterol 24-hydroxylase
 NCBI Official Synonym Full Names    cytochrome P450, family 46, subfamily A, polypeptide 1
 NCBI Official Symbol    CYP46A1 [Similar Products]
 NCBI Official Synonym Symbols   
CP46; CYP46
[Similar Products]
 NCBI Protein Information    cholesterol 24-hydroxylase; CH24H; cytochrome P450 46A1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
 UniProt Protein Name    Cholesterol 24-hydroxylase
 UniProt Synonym Protein Names   
Cytochrome P450 46A1
 Protein Family    Cholesterol 24-hydroxylase
 UniProt Gene Name    CYP46A1 [Similar Products]
 UniProt Synonym Gene Names    CYP46; CH24H [Similar Products]
 UniProt Entry Name    CP46A_HUMAN
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 NCBI Summary for CYP46A1    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP46A1    CYP46A1: Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Belongs to the cytochrome P450 family.

Protein type: EC 1.14.13.98; Lipid Metabolism - primary bile acid biosynthesis; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: iron ion binding; cholesterol 24-hydroxylase activity; heme binding; steroid hydroxylase activity

Biological Process: nervous system development; bile acid biosynthetic process; bile acid metabolic process; xenobiotic metabolic process; cholesterol catabolic process; sterol metabolic process
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 Research Articles on CYP46A1    1. results of meta-analysis suggested that CYP46A1 rs754203 is a minor risk factor for Alzheimer's disease
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CYP46A1 antibodyPathways associated with anti-CYP46A1 antibody
 Reference Product  PubMed Publications
 CYP27A1 antibody  >15 publications with CYP46A1 and CYP27A1
 CYP7A1 antibody  >8 publications with CYP46A1 and CYP7A1
 DHCR24 antibody  >3 publications with CYP46A1 and DHCR24
 LIPA antibody  >2 publications with CYP46A1 and LIPA
 SOAT1 antibody  >2 publications with CYP46A1 and SOAT1
 CYP39A1 antibody  >2 publications with CYP46A1 and CYP39A1
 CH25H antibody  >2 publications with CYP46A1 and CH25H
 DHCR7 antibody  >1 publications with CYP46A1 and DHCR7
 Products by Pathway  Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway antibodies  Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway Diagram
 Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway antibodies  Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway Diagram
 Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway antibodies  Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway Diagram
 Defective CYP17A1 Causes Adrenal Hyperplasia 5 (AH5) Pathway antibodies  Defective CYP17A1 Causes Adrenal Hyperplasia 5 (AH5) Pathway Diagram
 Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway antibodies  Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway Diagram
 Defective CYP1B1 Causes Glaucoma Pathway antibodies  Defective CYP1B1 Causes Glaucoma Pathway Diagram
 Defective CYP21A2 Causes Adrenal Hyperplasia 3 (AH3) Pathway antibodies  Defective CYP21A2 Causes Adrenal Hyperplasia 3 (AH3) Pathway Diagram
Diseases associated with anti-CYP46A1 antibodyOrgans/Tissues associated with anti-CYP46A1 antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >74 publications with CYP46A1 and Brain Diseases
 Nervous System Diseases Antibodies  >69 publications with CYP46A1 and Nervous System Diseases
 Alzheimer Disease Antibodies  >65 publications with CYP46A1 and Alzheimer Disease
 Mental Disorders Antibodies  >61 publications with CYP46A1 and Mental Disorders
 Liver Diseases Antibodies  >7 publications with CYP46A1 and Liver Diseases
 Fatty Liver Antibodies  >5 publications with CYP46A1 and Fatty Liver
 Dyslipidemias Antibodies  >5 publications with CYP46A1 and Dyslipidemias
 Cognition Disorders Antibodies  >4 publications with CYP46A1 and Cognition Disorders
 Atherosclerosis Antibodies  >4 publications with CYP46A1 and Atherosclerosis
 Brain Injuries Antibodies  >3 publications with CYP46A1 and Brain Injuries
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >112 publications with CYP46A1 and Brain
 Eye Antibodies  >10 publications with CYP46A1 and Eye
 Nerve Antibodies  >5 publications with CYP46A1 and Nerve
 Heart Antibodies  >3 publications with CYP46A1 and Heart
 Embryonic Tissue Antibodies  >1 publications with CYP46A1 and Embryonic Tissue
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