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anti-CHRNA4 antibody :: Rabbit CHRNA4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2519808
Immunohistochemistry (IHC)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CHRNA4, Polyclonal Antibody

 Also Known As   

CHRNA4 Polyclonal Antibody

 Product Synonym Names    EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4
 Product Gene Name   

anti-CHRNA4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    118504
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1.2mg/mL (lot specific)
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 Immunogen    Recombinant protein of human CHRNA4
 Calculated Molecular Weight: 70kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-CHRNA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CHRNA4 antibody

   This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1.
 Applications Tested/Suitable for anti-CHRNA4 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CHRNA4 antibody    WB: 1:200-1:1000
IHC: 1:25-1:100
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 Immunohistochemistry (IHC) of anti-CHRNA4 antibody    Immunohistochemistry of Human prostate cancer using CHRNA4 Polyclonal Antibody at dilution of 1:20
anti-CHRNA4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CHRNA4. It may not necessarily be applicable to this product.
 NCBI GI #    64654445
 NCBI GeneID    1137
 NCBI Accession #    AAH96292.1 [Other Products]
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 UniProt Secondary Accession #    Q4JGR7; Q4VAQ5; Q4VAQ6 [Other Products]
 UniProt Related Accession #    P43681 [Other Products]
 Molecular Weight    60,994 Da
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 NCBI Official Full Name    CHRNA4 protein
 NCBI Official Synonym Full Names    cholinergic receptor, nicotinic, alpha 4 (neuronal)
 NCBI Official Symbol    CHRNA4 [Similar Products]
 NCBI Official Synonym Symbols   
EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4
[Similar Products]
 NCBI Protein Information    neuronal acetylcholine receptor subunit alpha-4; cholinergic receptor, nicotinic, alpha polypeptide 4; neuronal nicotinic acetylcholine receptor alpha-4 subunit
 UniProt Protein Name    Neuronal acetylcholine receptor subunit alpha-4
 Protein Family    Neuronal acetylcholine receptor
 UniProt Gene Name    CHRNA4 [Similar Products]
 UniProt Synonym Gene Names    NACRA4 [Similar Products]
 UniProt Entry Name    ACHA4_HUMAN
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 NCBI Summary for CHRNA4    This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
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 UniProt Comments for CHRNA4    nAChRA4: a ligand-gated ion channels that binds acetylcholine and mediates fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors undergo an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. An integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor.

Protein type: Receptor, misc.; Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; cell soma; membrane; dendrite; integral to membrane; plasma membrane; cell junction; external side of plasma membrane

Molecular Function: acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; acetylcholine binding; ligand-gated ion channel activity

Biological Process: response to nicotine; regulation of action potential; B cell activation; behavioral response to nicotine; locomotory behavior; respiratory gaseous exchange; sensory perception of pain; DNA repair; signal transduction; regulation of dopamine secretion; synaptic transmission, cholinergic; neurological system process; membrane depolarization; regulation of inhibitory postsynaptic membrane potential; synaptic transmission; regulation of membrane potential; calcium ion transport; response to hypoxia; ion transport; response to oxidative stress; cognition

Disease: Epilepsy, Nocturnal Frontal Lobe, 1; Tobacco Addiction, Susceptibility To
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 Research Articles on CHRNA4    1. Data indicate the binding mode and modulatory mechanism of NS9283 at alpha4beta2 nicotinic acetylcholine receptors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CHRNA4 antibodyPathways associated with anti-CHRNA4 antibody
 Reference Product  PubMed Publications
 CHRNB2 antibody  >62 publications with CHRNA4 and CHRNB2
 CHRNA2 antibody  >23 publications with CHRNA4 and CHRNA2
 CHRNA7 antibody  >16 publications with CHRNA4 and CHRNA7
 CHRNA3 antibody  >15 publications with CHRNA4 and CHRNA3
 CHRNB4 antibody  >12 publications with CHRNA4 and CHRNB4
 NGF antibody  >2 publications with CHRNA4 and NGF
 Products by Pathway  Pathway Diagram
 Acetylcholine Binding And Downstream Events Pathway antibodies  Acetylcholine Binding And Downstream Events Pathway Diagram
 Activation Of Nicotinic Acetylcholine Receptors Pathway antibodies  Activation Of Nicotinic Acetylcholine Receptors Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway antibodies  Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway Diagram
 Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway antibodies  Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
 Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway antibodies  Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
Diseases associated with anti-CHRNA4 antibodyOrgans/Tissues associated with anti-CHRNA4 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >104 publications with CHRNA4 and Nervous System Diseases
 Epilepsy, Frontal Lobe Antibodies  >66 publications with CHRNA4 and Epilepsy, Frontal Lobe
 Seizures Antibodies  >51 publications with CHRNA4 and Seizures
 Attention Deficit Disorder with Hyperactivity Antibodies  >15 publications with CHRNA4 and Attention Deficit Disorder with Hyperactivity
 Sleep Disorders Antibodies  >14 publications with CHRNA4 and Sleep Disorders
 Neurobehavioral Manifestations Antibodies  >8 publications with CHRNA4 and Neurobehavioral Manifestations
 Dystonia Antibodies  >6 publications with CHRNA4 and Dystonia
 Epilepsy, Nocturnal Frontal Lobe, Type 1 Antibodies  >5 publications with CHRNA4 and Epilepsy, Nocturnal Frontal Lobe, Type 1
 Learning Disorders Antibodies  >4 publications with CHRNA4 and Learning Disorders
 Cognition Disorders Antibodies  >4 publications with CHRNA4 and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >67 publications with CHRNA4 and Brain
 Eye Antibodies  >3 publications with CHRNA4 and Eye
 Testis Antibodies  >1 publications with CHRNA4 and Testis
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