AAH96292.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,994 Da
NCBI Official Full Name
CHRNA4 protein
NCBI Official Synonym Full Names
cholinergic receptor, nicotinic, alpha 4 (neuronal)
NCBI Official Synonym Symbols
EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4 [Similar Products]
NCBI Protein Information
neuronal acetylcholine receptor subunit alpha-4; cholinergic receptor, nicotinic, alpha polypeptide 4; neuronal nicotinic acetylcholine receptor alpha-4 subunit
UniProt Protein Name
Neuronal acetylcholine receptor subunit alpha-4
UniProt Synonym Gene Names
UniProt Entry Name
ACHA4_HUMAN
NCBI Summary for CHRNA4
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
UniProt Comments for CHRNA4
nAChRA4: a ligand-gated ion channels that binds acetylcholine and mediates fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors undergo an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. An integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor.
Protein type: Receptor, misc.; Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 20q13.33
Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; cell soma; membrane; dendrite; integral to membrane; plasma membrane; cell junction; external side of plasma membrane
Molecular Function: acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; acetylcholine binding; ligand-gated ion channel activity
Biological Process: response to nicotine; regulation of action potential; B cell activation; behavioral response to nicotine; locomotory behavior; respiratory gaseous exchange; sensory perception of pain; DNA repair; signal transduction; regulation of dopamine secretion; synaptic transmission, cholinergic; neurological system process; membrane depolarization; regulation of inhibitory postsynaptic membrane potential; synaptic transmission; regulation of membrane potential; calcium ion transport; response to hypoxia; ion transport; response to oxidative stress; cognition
Disease: Epilepsy, Nocturnal Frontal Lobe, 1; Tobacco Addiction, Susceptibility To
Research Articles on CHRNA4
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Products associated with anti-CHRNA4 antibody
Pathways associated with anti-CHRNA4 antibody
Diseases associated with anti-CHRNA4 antibody
Organs/Tissues associated with anti-CHRNA4 antibody
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