Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow CHRNE rightarrow Polyclonal CHRNE  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Syndecan 1 (SDC1) ELISA Kit
 • CYTH1 ELISA Kit
 • CD3 Antibody
 • IL-6 (IL6) Antibody
 • APOBEC4 Antibody
 • Calcium Sensing Receptor (CASR) ELISA Kit
 • CD11b Antibody
 • MAPtau ELISA Kit
 • Interleukin 10 (IL-10) ELISA Kit
 • TNF-alpha Recombinant Protein
 • Lens Fiber Major Intrinsic Protein (MIP) ELISA Kit
 • Forkhead Box Protein O3 (FOXO3) ELISA Kit
 • integrin, alpha 4 (ITGA4) Antibody
 • HNRNPM Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CHRNE antibody :: Rabbit anti-Human CHRNE Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045408
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CHRNE, Polyclonal Antibody

★Popular Item★
 Also Known As   

CHRNE Antibody

 Product Synonym Names    Acetylcholine receptor subunit epsilon; CHRNE; ACHRE
 Product Gene Name   

anti-CHRNE antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    100725
 3D Structure    ModBase 3D Structure for Q04844
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
Section Bar
 Species    Human
 Immunogen    Recombinant human Acetylcholine receptor subunit epsilon protein (21-239AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1454 / sc-1455 / sc-13999
Section Bar
 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CHRNE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-CHRNE antibody

   After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
 Applications Tested/Suitable for anti-CHRNE antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Section Bar
 Western Blot (WB) of anti-CHRNE antibody    Western blot
All lanes: CHRNE antibody at 1.87ug/ml
Lane 1: A549 whole cell lysate
Lane 2: Jurkat whole cell lysate
Lane 3: Hela whole cell lysate
Lane 4: HepG-2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 55 kDa
Observed band size: 55 kDa

anti-CHRNE antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-CHRNE antibody    Immunohistochemistry of paraffin-embedded human liver tissue MBS7045408 at dilution 1:100
anti-CHRNE antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-CHRNE antibody    Immunohistochemistry of paraffin-embedded human liver cancer MBS7045408 at dilution 1:100
anti-CHRNE antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CHRNE. It may not necessarily be applicable to this product.
 NCBI GI #    4557463
 NCBI GeneID    1145
 NCBI Accession #    NP_000071.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000080.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q04844 [Other Products]
 UniProt Secondary Accession #    D3DTK6 [Other Products]
 UniProt Related Accession #    Q04844 [Other Products]
 Molecular Weight    54,697 Da
Table BarTOPTable Bar
 NCBI Official Full Name    acetylcholine receptor subunit epsilon
 NCBI Official Synonym Full Names    cholinergic receptor nicotinic epsilon subunit
 NCBI Official Symbol    CHRNE [Similar Products]
 NCBI Official Synonym Symbols   
ACHRE; CMS1D; CMS1E; CMS2A; CMS4A; CMS4B; CMS4C; FCCMS; SCCMS
[Similar Products]
 NCBI Protein Information    acetylcholine receptor subunit epsilon
 UniProt Protein Name    Acetylcholine receptor subunit epsilon
 Protein Family    Acetylcholine receptor
 UniProt Gene Name    CHRNE [Similar Products]
 UniProt Synonym Gene Names    ACHRE [Similar Products]
 UniProt Entry Name    ACHE_HUMAN
Section Bar
 NCBI Summary for CHRNE    Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009]
Section Bar
 UniProt Comments for CHRNE    nAChRE: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The muscle AChR is the major target antigen in the autoimmune disease myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs. Defects in CHRNE are a cause of congenital myasthenic syndrome slow-channel type (SCCMS). SCCMS is the most common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. SCCMS is caused by kinetic abnormalities of the AChR, resulting in prolonged endplate currents and prolonged AChR channel opening episodes. Defects in CHRNE are a cause of congenital myasthenic syndrome fast-channel type (FCCMS). FCCMS is a congenital myasthenic syndrome characterized by kinetic abnormalities of the AChR. In most cases, FCCMS is due to mutations that decrease activity of the AChR by slowing the rate of opening of the receptor channel, speeding the rate of closure of the channel, or decreasing the number of openings of the channel during ACh occupancy. The result is failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential. Defects in CHRNE are a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (CMS-ACHRD). CMS-ACHRD is a postsynaptic congenital myasthenic syndrome. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily.

Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Channel, cation

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: acetylcholine binding; acetylcholine receptor activity; cation transmembrane transporter activity; ligand-gated ion channel activity

Biological Process: muscle contraction; neuromuscular synaptic transmission; response to nicotine; signal transduction; synaptic transmission, cholinergic; transport

Disease: Myasthenic Syndrome, Congenital, 4a, Slow-channel; Myasthenic Syndrome, Congenital, 4b, Fast-channel; Myasthenic Syndrome, Congenital, Associated With Acetylcholine Receptor Deficiency
Table BarTOPTable Bar
 Research Articles on CHRNE    1. mutational analysis of CHRNE revealed a homozygous 1293insG, which is a well-known low-expressor receptor mutation in patients with epidermolysis bullosa simplex and congenital myasthenic syndrome.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with anti-CHRNE antibodyDiseases associated with anti-CHRNE antibody
 Products by Pathway  Pathway Diagram
 Acetylcholine Binding And Downstream Events Pathway antibodies  Acetylcholine Binding And Downstream Events Pathway Diagram
 Activation Of Nicotinic Acetylcholine Receptors Pathway antibodies  Activation Of Nicotinic Acetylcholine Receptors Pathway Diagram
 ErbB2/ErbB3 Signaling Events Pathway antibodies  ErbB2/ErbB3 Signaling Events Pathway Diagram
 Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway antibodies  Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
 Postsynaptic Nicotinic Acetylcholine Receptors Pathway antibodies  Postsynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
 Presynaptic Nicotinic Acetylcholine Receptors Pathway antibodies  Presynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >38 publications with CHRNE and Nervous System Diseases
 Myasthenic Syndrome, Congenital, Fast-Channel Antibodies  >4 publications with CHRNE and Myasthenic Syndrome, Congenital, Fast-Channel
 Mental Disorders Antibodies  >1 publications with CHRNE and Mental Disorders
 Fever Antibodies  >1 publications with CHRNE and Fever
 Nerve Degeneration Antibodies  >1 publications with CHRNE and Nerve Degeneration
 Hyperplasia Antibodies  >1 publications with CHRNE and Hyperplasia
 Myasthenic syndrome, congenital, postsynaptic slow-channel Antibodies  >1 publications with CHRNE and Myasthenic syndrome, congenital, postsynaptic slow-channel
Organs/Tissues associated with anti-CHRNE antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with CHRNE and Brain
 Eye Antibodies  >1 publications with CHRNE and Eye
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions