AAI11803.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,020 Da
NCBI Official Full Name
CHRNG protein
NCBI Official Synonym Full Names
cholinergic receptor nicotinic gamma subunit
NCBI Official Synonym Symbols
NCBI Protein Information
acetylcholine receptor subunit gamma
UniProt Protein Name
Acetylcholine receptor subunit gamma
UniProt Synonym Gene Names
NCBI Summary for CHRNG
The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq, Sep 2009]
UniProt Comments for CHRNG
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Research Articles on CHRNG
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Products associated with anti-CHRNG antibody
Pathways associated with anti-CHRNG antibody
Diseases associated with anti-CHRNG antibody
Organs/Tissues associated with anti-CHRNG antibody
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